|
|
早产儿脑损伤治疗的研究进展
|
Abstract:
自从2016年“二胎”政策全面放开后，高龄产妇人数增加，导致早产儿的发生率较前增长。随着围产期护理及新生儿技术不断完善，与此同时早产儿的存活率呈现增长的趋势，预后也引起了人们很大的关注，尤其早产儿脑损伤常遗留不同程度的神经发育障碍，包括严重的认知缺陷和运动障碍，如脑瘫等，是现代社会面临的较严重的全球健康问题之一。因此本文就早产儿脑损伤的最近的治疗进展进行综述。
Since the “two-child” policy was fully implemented in 2016, the number of el-derly women has increased, leading to an increase in the incidence of premature infants. As peri-natal care and neonatal technology constantly improve, at the same time the survival rate of prem-ature growth trend, prognosis also caused great attention, especially premature brain damage often left different degrees of neurodevelopmental disorders, including serious cognitive defects and motor disorders, such as cerebral palsy, is one of the serious global health problems facing modern society. Thus this review addresses the recent progress in the treatment of brain injury in preterm infants.
| [1] | Walani, S.R. (2020) Global Burden of Preterm Birth. International Journal of Gynecology & Obstetrics, 150, 31-33.
https://doi.org/10.1002/ijgo.13195 |
| [2] | 万立新, 易立岩, 何欢, 等. 2018年吉林省新生儿低出生体重发生率及影响因素分析[J]. 现代预防医学, 2020, 47(21): 3903-3907. |
| [3] | 朱萍, 杜旭东, 李宓儿, 等. 2008-2014年成都市新都区低出生体重儿发生率变化趋势及影响因素分析[J]. 现代预防医学, 2017, 44(8): 1428-1432. |
| [4] | 蒋思远, 李淑涓, 曹云, 等. 我国25家III级新生儿重症监护病房极低出生体重儿出院结局的横断面调查[J]. 中华围产医学杂志, 2018, 21(6): 394-400. |
| [5] | 张丹, 张军, 杨钰荣, 等. 肠道菌群与早产儿脑发育及神经认知行为关系的研究进展[J]. 中国儿童保健杂志, 2023: 1-4. |
| [6] | Yates, N., Gunn, A.J., Bennet, L., et al. (2021) Preventing Brain Inju-ry in the Preterm Infant-Current Controversies and Potential Therapies. International Journal of Molecular Sciences, 22, 1671. https://doi.org/10.3390/ijms22041671 |
| [7] | 刘敬, 俞惠民, 毛健, 等. 早产儿脑损伤诊断与防治专家共识[J]. 中国当代儿科杂志, 2012, 14(12): 883-884. |
| [8] | Guo, X., Geng, Y., Zhang, L., et al. (2021) Early Diagnosis of Brain Injury in Premature Infants Based on Amplitude-Integrated EEG Scoring System. Journal of Healthcare Engi-neering, 2021, Article ID: 6684818.
https://doi.org/10.1155/2021/6684818 |
| [9] | Perrone, S., Lembo, C., Gironi, F., et al. (2022) Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use. Antioxidants (Basel), 11, 652. https://doi.org/10.3390/antiox11040652 |
| [10] | Zhang, Y.Y., Yao, M., Zhu, K., et al. (2022) Neurological Recovery and Antioxidant Effect of Erythropoietin for Spinal Cord Injury: A Systematic Review and Meta-Analysis. Frontiers in Neurology, 13, Article ID: 925696.
https://doi.org/10.3389/fneur.2022.925696 |
| [11] | Wu, Y.W., Mathur, A.M., Chang, T., et al. (2016) High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics, 137, e20160191. |
| [12] | 王欣萍, 刘登基, 付中秋. 不同剂量重组人促红细胞生成素治疗早产儿脑损伤的效果分析[J]. 中国妇幼健康研究, 2022, 33(9): 27-31. |
| [13] | 唐亮, 陈晓晴, 谭伟强. 早期应用促红细胞生成素对早产儿神经系统保护的有效性和安全性的Meta分析[J]. 中国中西医结合儿科学, 2022, 14(4): 300-307. |
| [14] | Robinson, S., Winer, J.L., Chan, L., et al. (2018) Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Mi-crostructural Deficits Following Early Severe Traumatic Brain Injury in Rats. Frontiers in Neurology, 9, Article No. 451. https://doi.org/10.3389/fneur.2018.00451 |
| [15] | MacLeod, D. and MacLeod, J. (1999) Magnesium: Physiology and Pharmacology. British Journal of Anaesthesia, 83, 972-973. |
| [16] | Lingam, I. and Robertson, N.J. (2018) Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient. Developmental Neuroscience, 40, 1-12.
https://doi.org/10.1159/000484891 |
| [17] | Singhi, S. and Johnston, M. (2019) Recent Advances in Perinatal Neuro-protection. F1000Research, 8, 817.
https://doi.org/10.12688/f1000research.20722.1 |
| [18] | Koning, G., Leverin, A.L., Nair, S., et al. (2019) Magnesium Induces Preconditioning of the Neonatal Brain via Profound Mitochondrial Protection. Journal of Cerebral Blood Flow & Metabolism, 39, 1038-1055.
https://doi.org/10.1177/0271678X17746132 |
| [19] | Ayed, M., Ahmed, J., More, K., et al. (2022) Antenatal Magne-sium Sulfate for Preterm Neuroprotection: A Single-Center Experience from Kuwait Tertiary NICU. Biomedicine Hub, 7, 80-87. https://doi.org/10.1159/000525431 |
| [20] | Wolf, H.T., Huusom, L.D., Henriksen, T.B., et al. (2020) Magne-sium Sulphate for Fetal Neuroprotection at Imminent Risk for Preterm Delivery: A Systematic Review with Me-ta-Analysis and Trial Sequential Analysis. BJOG, 127, 1180- 1188. https://doi.org/10.1111/1471-0528.16238 |
| [21] | Brookfield, K.F. and Vinson, A. (2019) Magnesium Sulfate Use for Fetal Neuroprotection. Current Opinion in Obstetrics and Gynecology, 31, 110-115. https://doi.org/10.1097/GCO.0000000000000529 |
| [22] | Ohhashi, M., Yoshitomi, T., Sumiyoshi, K., et al. (2016) Magnesium Sulphate and Perinatal Mortality and Morbidity in Very-Low-Birthweight Infants Born between 24 and 32 Weeks of Gestation in Japan. The European Journal of Obstetrics & Gynecology and Reproductive Biology, 201, 140-145. https://doi.org/10.1016/j.ejogrb.2016.03.048 |
| [23] | Jonsdotter, A., Rocha-Ferreira, E., Hagberg, H., et al. (2022) Maternal and Fetal Serum Concentrations of Magnesium after Administration of a 6-g Bolus Dose of Magnesium Sulfate (MgSO(4)) to Women with Imminent Preterm Delivery. Acta Obstetricia et Gynecologica Scandinavica, 101, 856-861. https://doi.org/10.1111/aogs.14372 |
| [24] | Reeves, S.A., Gibbs, R.S. and Clark, S.L. (2011) Magnesium for Fetal Neuroprotection. The American Journal of Obstetrics and Gynecology, 204, 201-202. https://doi.org/10.1016/j.ajog.2011.01.014 |
| [25] | ACOG (2012) Practice Bulletin No. 127: Management of Preterm Labor. Obstetrics & Gynecology, 119, 1308-1317.
https://doi.org/10.1097/AOG.0b013e31825af2f0 |
| [26] | Tordjman, S., Chokron, S., Delorme, R., et al. (2017) Mela-tonin: Pharmacology, Functions and Therapeutic Benefits. Current Neuropharmacology, 15, 434-443. https://doi.org/10.2174/1570159X14666161228122115 |
| [27] | Cardinali, D.P. (2019) An Assessment of Melatonin’s Therapeutic Value in the Hypoxic-Ischemic Encephalopathy of the Newborn. Frontiers in Synaptic Neuroscience, 11, Article No. 34. https://doi.org/10.3389/fnsyn.2019.00034 |
| [28] | 张海洋, 陆翔宇, 张家华, 等. 褪黑素对LPS致大鼠海马炎性损伤的保护作用[J]. 畜牧兽医学报, 2021, 52(1): 226-234. |
| [29] | Pang, R., Han, H.J., Meehan, C., et al. (2022) Efficacy of Melatonin in Term Neonatal Models of Perinatal Hypoxia-Ischaemia. Annals of Clinical and Transla-tional Neurology, 9, 795-809. https://doi.org/10.1002/acn3.51559 |
| [30] | Aridas, J.D., Yawno, T., Sutherland, A.E., et al. (2021) Melatonin Augments the Neuroprotective Effects of Hypothermia in Lambs Following Perinatal Asphyxia. Journal of Pineal Research, 71, e12744.
https://doi.org/10.1111/jpi.12744 |
| [31] | Yang, L., Yu, X., Zhang, Y., et al. (2021) Encephalopathy in Preterm In-fants: Advances in Neuroprotection with Caffeine. Frontiers in Pediatrics, 9, Article ID: 724161. https://doi.org/10.3389/fped.2021.724161 |
| [32] | Raoofi, A., Delbari, A., Nasiry, D., et al. (2022) Caffeine Modu-lates Apoptosis, Oxidative Stress, and Inflammation Damage Induced by Tramadol in Cerebellum of Male Rats. Journal of Chemical Neuroanatomy, 123, Article ID: 102116. https://doi.org/10.1016/j.jchemneu.2022.102116 |
| [33] | Yang, L., Yu, X., Zhang, Y., et al. (2022) Caffeine Treatment Started before Injury Reduces Hypoxic-Ischemic White-Matter Damage in Neonatal Rats by Regulating Phenotypic Microglia Polarization. Pediatric Research, 92, 1543-1554. https://doi.org/10.1038/s41390-021-01924-6 |
| [34] | 许钰枚. 枸橼酸咖啡因对脑损伤早产儿的影响[J]. 中外医学研究, 2022, 20(13): 34-37. |
| [35] | 李明磊, 孟令建, 杜薇薇, 等. 脑损伤早产儿血清25-羟维生素D水平变化及其与IL-17、IL-10水平的相关性[J]. 山东医药, 2022, 62(14): 74-77. |
| [36] | 刘亿荣, 曾春英, 张文静, 等. 维生素D缺乏与早产儿缺氧缺血性脑病的相关性研究[J]. 中国儿童保健杂志, 2021, 29(12): 1355-1358. |
| [37] | Gunn, A.J. and Bennet, L. (2008) Brain Cooling for Preterm Infants. Clinics in Perinatology, 35, 735-748.
https://doi.org/10.1016/j.clp.2008.07.012 |
| [38] | 王彤, 王丽娟, 付洪涛, 等. 局部及全身亚低温疗法针对早产儿窒息治疗效果的对比分析[J]. 广西医科大学学报, 2020, 37(4): 727-731. |
| [39] | Peng, X., Song, J., Li, B., et al. (2020) Umbilical Cord Blood Stem Cell Therapy in Premature Brain Injury: Opportunities and Challenges. Journal of Neuro-science Research, 98, 815-825. https://doi.org/10.1002/jnr.24548 |
| [40] | Rallapalli, S., Guhathakurta, S., Narayan, S., et al. (2019) Generation of Clinical-Grade Red Blood Cells from Human Umbilical Cord Blood Mononuclear Cells. Cell and Tissue Research, 375, 437-449.
https://doi.org/10.1007/s00441-018-2919-6 |
| [41] | Xi, Y., Yue, G., Gao, S., et al. (2022) Human Umbilical Cord Blood Mononuclear Cells Transplantation for Perinatal Brain Injury. Stem Cell Research & Therapy, 13, 458. https://doi.org/10.1186/s13287-022-03153-y |
| [42] | Aridas, J.D., McDonald, C.A., Paton, M.C., et al. (2016) Cord Blood Mononuclear Cells Prevent Neuronal Apoptosis in Response to Perinatal Asphyxia in the Newborn Lamb. The Journal of Physiology, 594, 1421-1435.
https://doi.org/10.1113/JP271104 |
| [43] | Yu, Y., Yan, Y., Luo, Z., et al. (2019) Effects of Human Umbilical Cord Blood CD34(+) Cell Transplantation in Neonatal Hypoxic-Ischemia Rat Model. Brain and Development, 41, 173-181.
https://doi.org/10.1016/j.braindev.2018.08.007 |
