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大麻二酚在神经病理性疼痛中的作用研究进展
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Abstract:
神经病理性疼痛(Neuropathic Pain, NP)因为发病率高，目前缺乏有效的治疗药物，严重影响患者的生活质量，也给个人和社会带来沉重负担。研究和探讨新的治疗药物和治疗方案是亟待解决的重要课题。大麻二酚(Cannabidiol, CBD)是一种非精神活性的植物大麻素，具有良好的耐受性和安全性，在多种NP模型中都表现出镇痛作用；但由于对其药理学特性尚未完全研究清楚，临床应用仍然有限。本文主要对CBD在NP中的治疗作用和主要分子靶点予以综述，为相关研究与临床应用提供理论依据。
Due to the high incidence of Neuropathic Pain (NP) and the lack of effective drug treatments, NP affects the life quality of patients severely and brings a heavy burden to individuals and society. It is an urgent task to study and explore new therapeutic drugs and treatment regimens for NP. Cannabidiol (CBD) is a non-psychoactive plant cannabinoid with good tolerance and safety, and has shown analgesic effects in a variety of NP models. However, due to its complex pharmacological properties, its clinical application is still limited. This article mainly reviews the therapeutic effects and major molecular targets of CBD in NP, hoping to provide a theoretical basis for related research and clinical application.
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