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MHD患者血Hcy、PTH、β2-MG与认知障碍的相关性研究
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Abstract:
认知障碍在慢性肾脏病(chronic kidney disease, CKD)患者的所有阶段都很常见，大多数接受维持性血液透析(maintenance hemodialysis, MHD)治疗的终末期肾病(end stage renal disease, ESRD)患者通常患有某种程度的认知功能障碍，这会损害他们的服药依从性和生活质量，认知障碍可能导致长期的不良后果，包括痴呆和死亡。与普通人群相比，MHD患者轻度认知障碍(mild cognitive im-pairment, MCI)患病率较高，据报道接受血液透析的ESRD患者认知障碍发生率高达70%，MCI被认为是MHD患者全因死亡率的独立预测因子。因此，积极控制MHD患者认知障碍的危险因素，早发现、早干预对于提高MHD患者生活质量有重要意义。
Cognitive impairment is common in all stages of chronic kidney disease (CKD) patients, and most end-stage renal disease (ESRD) patients who re-ceive maintenance hemodialysis (MHD) treatment typically suffer from some degree of cognitive impairment, which can impair their medication adherence and quality of life. Cognitive impairment may lead to long-term adverse consequences, Including dementia and death. Compared with the general population, MHD patients have a higher incidence of mild cognitive impairment (MCI), with a reported incidence of 70% in ESRD patients undergoing hemodialysis. MCI is considered an inde-pendent predictor of all-cause mortality in MHD patients. Therefore, actively controlling the risk factors of cognitive impairment in MHD patients, early detection and intervention are of great sig-nificance for improving the quality of life of MHD patients.
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