Background:Hematopoietic
system is seriously affected by tuberculosis. It exerts a dazzling variety of
hematological effects involving both cell lines and plasma components[1]. Anemia and leukopenia are not unusual with tuberculosis (TB), but
pancytopenia is rare [2]. Findings: In this report, we described a case of a 42 years man
presenting bleeding and pancytopenia; bacteriological pulmonary TB was
established by genotypic rapid test and treatment following the WHO guidelines on drug-sensitive TB treatment. Patient recovered
entirely with the WHO recommended regimen associated with general and local treatment of the bleeding.Conclusion:
This case report emphasizes the importance of always suspecting tuberculosis in
a tuberculosis-endemic area, even when the
References
[1]
Batool, Y., Pervaiz, G., Arooj, A. and Fatima, S. (2022) Hematological Manifestations in Patients Newly Diagnosed with Pulmonary Tuberculosis. Pakistan Journal of Medical Sciences, 38, 1968-1972. https://doi.org/10.12669/pjms.38.7.5911
[2]
Mulenga, C., Kayembe, J., Kabengele, B. and Bakebe, A. (2017) Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa. Journal of Tuberculosis Research, 5, 243-257. https://doi.org/10.4236/jtr.2017.54026
[3]
William, D.M. (1993) Pancytopenia, Aplastic Anemia and Pure Red Cell Aplasia. In Greer, J.P., et al., Eds., Winthrobe’s Clinical Hematology, 10th Edition, Lippincott Williams & Wilkins, Baltimore, 1440-1484.
[4]
Avasthi, R., Mohanty D., Chandhary S.C, Mishra K. (2010) Disseminated Tuberculosis: Interesting Hematological Observation. Journal of the Association of Physicians of India, 58, 243-244.
[5]
Singh, K.J., Ahluwalia, G., Sharma, S.K., Chaudry, V.P. and Anant, M. (2001) Significance of Hematological Manifestations in Patient with Tuberculosis. Journal of the Association of Physicians of India, 788, 790-794.
[6]
Hunt B.J., Andrews V. and Pettingole, K.W. (1987) The Significance of Pancytopenia in Military Tuberculosis. Postgraduate Medical Journal, 63, 801-804. https://doi.org/10.1136/pgmj.63.743.801
[7]
Barzegari, S., Mafshari, M., Movahednia, M. and Moosazadeh, M. (2019) Prevalence of Anemia among Patients with Tuberculosis: A Systematic Review and Meta-Analysis. Indian Journal of Tuberculosis, 66, 299-307. https://doi.org/10.1016/j.ijtb.2019.04.002
[8]
Tiresse, N. and Allaoui, M. (2018) Tuberculose Multifocale révelée par une Pancytopenia à Propos d’un Cas. Pan African Medical Journal, 31, Article No. 92.
[9]
Katzen, H. and Spagnolo, S.V. (1980) Bone Marrow Necrosis from Miliary Tuberculosis. JAMA, 244, 2438-2439. https://doi.org/10.1001/jama.1980.03310210040024
[10]
Dutta, S., Mohta, R. and Pati, H.P. (1999) Tuberculosis Pure Red Cells Aplasia. IJTLD, 3, 361-362.
[11]
Dolugama, C. and Gawarammna, I.B. (2018) Fever with Pancytopenia: An Unusual Presentation of Extra-Pulmonary Tuberculosis: A Case Report. Journal of Medical Case Reports, 12, Article No. 58. https://doi.org/10.1186/s13256-018-1596-0
[12]
WHO (2022) WHO Consolidated Guidelines on Tuberculosis: Module 4: Treatment: Drug-Susceptible Tuberculosis Treatment. https://www.who.int/publications/i/item/9789240048126
[13]
Bafinger, J.J. and Schlossberg, D. (2007) Fever of Unknon Origin Caused by Tuberculosis: Review Articles. Infectious Disease Clinics of North America, 21, 947-962. https://doi.org/10.1016/j.idc.2007.08.001
