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Bioprocess 2023
干细胞外泌体在阿尔茨海默病中的研究进展
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Abstract:
阿尔茨海默病(Alzheimer’s Disease, AD)是一种病理机制复杂、以进行性认知功能障碍为主的中枢神经系统疾病，目前仍缺乏有效的治疗方法。间充质干细胞(Mesenchymal Stem Cells, MSCs)外泌体已被证实促进抗炎和Aβ降解，针对AD的病理生理分子机制特征从根本上改善AD症状，因其尺寸、形状、材料等特殊性，视为药物递送系统软纳米颗粒候选载体，有助于解决生物利用度问题，有效改善药物药动学和药效学性能。本文主要介绍AD病理研究最新进展、外泌体抑制Aβ蛋白表达水平方式及药物新型运输载体传递系统构建前沿，为AD治疗提供新的视角。
Alzheimer’s Disease (AD) is a central nervous system disease with a complex pathological mechanism and progressive cognitive dysfunction, and there is still no effective treatment. Mesenchymal Stem Cells (MSCs) exosomes promote anti-inflammatory, accelerate Aβ degradation, and achieve therapeutic effects for the pathological characteristics of AD, and can be used as nano-drug delivery systems to effectively solve the problem of bioavailability and improve drug pharmacokinetics and pharmacodynamic properties due to their size, shape, material and other particularities. This article mainly introduces the latest progress in AD pathology research and the attempts of exosomes to improve Aβ clearance to construct a drug delivery system, which provides a new perspective for AD treatment.
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