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核苷类抗病毒药物的研究进展
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Abstract:
核苷类似物是在临床上广泛使用的一类抗病毒和抗肿瘤药物，在特异性治疗以及广谱抗病毒领域都发挥着至关重要的作用。但在临床使用过程中出现的耐药性、毒性和二重感染等问题给该类药物的发展带来挑战。研究发现通过化学修饰可以影响核苷的抗病毒效力、安全性和耐药性。本文概述了以传统核苷类化合物的结构为基础，从碱基、糖环、磷酸基及糖苷键等几个方面进行结构修饰的研究进展，为进一步开发高抗病毒活性核苷类似物提供借鉴。
Modified nucleosides are a major class of anti-virus and anti-tumor drugs, which are widely used in the clinic. However, issues including the emergence of drug resistance, toxicity and superinfection have posed new challenges for nucleoside-based antiviral drug discovery. Many research found that chemical manipulation could impact the antiviral potency, safety, and drug resistance of nucleosides. This article provides an overview of modification of traditional nucleoside framework in order to provide reference for further research and development of highly antiviral nucleoside analogues.
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