Background: Neurocognitive impairments are
common among stroke survivors. Despite their negative impact on daily life,
their evolving, and determinants are not fully known in our context. To determine evolving characteristics of post-stroke cognitive
impairment in the 3rd month as well as determinants among Kinshasa’s adult
survivors is the aim of this study. Methods: We sought to determine
neurocognitive deficits in the 3rd month in a prospective single-group cohort
study in 3 hospital centers in Kinshasa. Eighty-six adult stroke survivors with
a neurological and neuroimaging computerized diagnosis of stroke were assessed
using MOCA (Montreal Cognitive Assessment) in the first and the third months
post-stroke. Results: Neurocognitive disorders ranged from 79.1% in the
first month to 54.7% in the third month after stroke (with 4.7% with severe
decline). Gender female [AOR = 86.3 (CI95%: 2.8-2643.7); p<0.01], Chronic hypertension ([AOR
= 26.8 (CI95%: 2.55-282.55);p<0.01]), the pathological lipid profile [AOR = 8.7 (CI95%: 1.10-68.82); p = 0.
References
[1]
Jacquin, A., Binquet, C., Rouaud, O., Graule-Petot, A., Daubail, B., Osseby, G.V., et al. (2014) Post Stroke Cognitive Impairment: High Prevalence and Determining Factors in a Cohort of Mild Stroke. Journal of Alzheimer’s Disease, 40, 1029-1038.
https://doi.org/10.3233/JAD-131580
[2]
Washida, K., Kowa, H., Hamaguchi, H., Tachibana, H., Sekiguchi, H., et al. (2015) Clinical Features Diagnosis and Treatment of Post Stroke Cognitive Impairment. Austin Journal of Clinical Neurology, 2, Article 1031.
[3]
Jin, Y.P., Di Legge, S., Ostbye, T., Feightner, J.W. and Hachinski, V. (2006) The Reciprocal Risks of Stroke and Cognitive Impairment in an Elderly Population. Alzheimer’s & Dementia, 2, 171-178. https://doi.org/10.1016/j.jalz.2006.03.006
[4]
Douiri, A., Rudd, A.G. and Wolfe, C.D. (2013) Prevalence of Post Stroke Cognitive Impairment: South London Stroke Register 1995-2010. Stroke, 44, 138-145.
https://doi.org/10.1161/STROKEAHA.112.670844
[5]
Rasquin, S.M., Verhey, F.R., Van Oostenbrugge, R.J., Lousberg, R. and Lodder, J. (2004) Demographic and CT Scan Features Related to Cognitive Impairement in the First Year after Stroke. Journal of Neurology, Neurosurgery & Psychiatry, 75, 1562-1567. https://doi.org/10.1136/jnnp.2003.024190
[6]
Ihle-Hansen, H., Thommessen, B., Wyller, T.B., et al. (2011) Incidence and Subtypes of MCI and Dementia 1 Year after First-Ever Stroke in Patients without Pre-Existing Cognitive Impairment. Dementia and Geriatric Cognitive Disorders, 32, 401-407.
https://doi.org/10.1159/000335361
[7]
Ivan, C.S., Seshadri, S., Beiser, A., et al. (2004) Dementia after Stroke: The Framingham Study. Stroke, 35, 1264-1268.
https://doi.org/10.1161/01.STR.0000127810.92616.78
[8]
Akinyemi, R.O., Allan, L., Owolabi, M.O., Akinyemi, J.O., Ogbole, G., Ajani, A., Firbank, M., Ogunniyi, A. and Kalaria, R.N. (2014) Profile and Determinants of Vascular Cognitive Impairment in African Stroke Survivors: The Cog Fast Nigeria Study. Journal of the Neurological Sciences, 346, 241-249.
https://doi.org/10.1016/j.jns.2014.08.042
[9]
Danovska, M., Stamenov, B., Alexandrova, M. and Peychinska, D. (2012) Post Stoke Cognitive Impairment—Phenomenology and Pronostics Factors. Journal of IMAB-Annual Proceeding, 18, 290-297. https://doi.org/10.5272/jimab.2012183.290
[10]
Nasreddine, Z.S., Phillips, N.A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Chertkow, H., et al. (2005) The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool for Mild Cognitive Impairment. Journal of the American Geriatrics Society, 53, 695-699 https://doi.org/10.1111/j.1532-5415.2005.53221.x
[11]
Tu, Q., Ding, B., Yang, X., et al. (2014) The Current Situation on Vascular Cognitive Impairment after Ischemic Stroke in Changsha. Archives of Gerontology and Geriatrics, 58, 236-247. https://doi.org/10.1016/j.archger.2013.09.006
[12]
Yu, K.H., Cho, S.J., Oh, M.S., Jung, S., Lee, J.H., Shin, J.H., Koh, I.S., Cha, J.K., Park, J.M., Bae, H.J., Kang, Y. and Lee, B.C. (2013) Korean-Vascular Cognitive Impairment Harmonization Standards in a Multicenter Prospective Stroke Cohort in Korea. Stroke, 44, 786-788. https://doi.org/10.1161/STROKEAHA.112.668343
[13]
Chen, X.L., et al. (2016) Predictors for Vascular Cognitive Impairment in Stroke Patients. BMC Neurology, 16, Article No. 115.
https://doi.org/10.1186/s12883-016-0638-8
[14]
Mapoure, Y.N., et al. (2017) Post Stroke Cognitive Impairment in Douala (Cameroon). African Journal of Neurological Sciences, 36, 43-52.
[15]
Delecraz, J. (2016) Reserve Cognitive: Qu’est-ce que c’est, qu’elle relation a-t-elle avec le vieillissement cérébral et la maladie d’Alzheimer et comment l’augmenter? Cognitif Santé, Cerveau Neurosciences, Nov 30.
https://yourbrain.health/fr/reserve-cognitive/
[16]
Salvadori, E., Passi, M., Poggesi, A., Chili, G., Inzitari, D., Pantoni, L., et al. (2013) Predictive Value of MOCA in the Acute Phase of Stroke on the Diagnosis Mid-Term Cognitive Impairment. Journal of Neurology, 260, 2220-2227.
https://doi.org/10.1007/s00415-013-6962-7
[17]
Seux, M.L. and Forette, F. (1999) Effects of Hypertension and Its Treatment on Mental Function. Current Hypertension Report, 1, 232-237.
https://doi.org/10.1007/s11906-999-0026-5
[18]
Kalaria, R.N., Akinyemi, R. and Ihara, M. (2016) Stroke Injury, Cognitive Impairment and Vascular Dementia. Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, 1862, 915-925.
https://doi.org/10.1016/j.bbadis.2016.01.015
[19]
Anstey, K.J., Lipnicki, D.M. and Low, L.F. (2008) Cholesterol as a Risk Factor for Dementia and Cognitive Decline: A Systematic Review of Prospective Studies with Mate-Analysis. The American Journal of Geriatric Psychiatry, 16, 343-354.
https://doi.org/10.1097/01.JGP.0000310778.20870.ae
[20]
Zou, Y., Zhu, Q., Deng, Y., Duan, J., Pan, L., Tu, Q., et al. (2014) Vascular Risk Factors and Mild Cognitive Impairment in the Elderly Population in Southwest China. American Journal of Alzheimer’s Disease & Other Dementias, 29, 242-247.
https://doi.org/10.1177/1533317513517042