Thyroid metabolism is orchestrated by the action of various minerals and trace elements including iron, iodine, selenium, and zinc. Iron deficiency, specifically deficiency in serum ferritin levels, is one of the common causes of thyroid dysfunction. Our objective was to evaluate the relationship between serum ferritin levels and circulating thyroid hormones. For this, a retrospective analysis was performed on 16,512 individuals who tested for serum levels of ferritin and thyroid profile at Vibrant America Clinical Laboratories. Subjects were stratified based on the serum levels of ferritin. Age (p < 0.0001) was found to be a significant factor in altering serum ferritin levels and also serum ferritin levels were significantly associated with varying levels of thyroid hormones in both males and females, with the levels of T4 (p < 0.0001) and RT3 (p < 0.0001) being the most significant. The levels of FT4 (p < 0.0001) and TSH (p = 0.0120) were significantly associated but did not exhibit any change in expression levels. Serum ferritin was found to be positively correlated with free thyroxine (r = 0.04325, p < 0.0001) and inversely correlated with serum triiodothyronine (r = −0.03232, p < 0.0001). Analysis of Linear association by Pearson’s correlation exhibited a considerable correlation between varying serum ferritin levels with all tested thyroid hormones. The study concludes that serum ferritin levels were associated with thyroid hormone synthesis and metabolism in individuals with optimal levels of circulating ferritin.
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