Rheumatoid
arthritis (RA) and gout are common diseases, but their coexistence is rare. We
describe the case of a 76-year-old man with hypertension who had been treated
for gout for 20 years on allopurinol and colchicine. He was seen in
consultation for deforming polyarthritis of the small and large joints, which
had been evolving for about 2 years. The acute episode occurred 10 days earlier
with the onset of bilateral and symmetrical polyarthritis affecting the large
and small joints. The physical examination revealed a peripheral joint syndrome
with ulnar gale force deformities of the hands and several buttonhole
deformities of the fingers. In addition, there were nodules, some of which were
fistulised, giving rise to a chalky slurry. The biology revealed an
inflammatory syndrome in addition to rheumatoid factors and ACPA, which were
elevated. Biological analysis of the nodular fluid revealed clusters of sodium
urate crystals and ultrasound scans of the joints revealed a double-contour
appearance in several joints. The diagnosis of RA was made using the 2010
ACR/EULAR criteria. The patient was treated as an outpatient with
corticosteroids before being put on methotrexate. It is important to understand
that these two conditions can occur at the same time, so it is important to
consider them when treating patients with gout or RA.
References
[1]
Chiou, A., et al. (2020) Coexistent Hyperuricemia and Gout in Rheumatoid Arthritis: Associations with Comorbidities, Disease Activity, and Mortality. Arthritis Care & Research, 72, 950-958. https://doi.org/10.1002/acr.23926
[2]
Zonana-Nacach, A., Alarcón, G.S. and Daniel, W.W. (1996) Rheumatoid Arthritis Preceding the Onset of Polyarticular Tophaceous Gout. Annals of the Rheumatic Diseases, 55, 489-490. https://doi.org/10.1136/ard.55.7.489-c
[3]
Jebakumar, A.J., Udayakumar, P.D., Crowson, C.S. and Matteson, E.L. (2013) Occurrence of Gout in Rheumatoid Arthritis: It Does Happen! A Population-Based Study. International Journal of Clinical Rheumatology, 8, 433-437.
[4]
Modesto dos Santos, V., Cézar, B.F., Barbosa, E.R. and de O. Carvalho, F.R.G.F. (2005) Coexistent Gout and Rheumatoid Arthritis: A Case Report. British Journal of Hospital Medicine, 66, 704-705. https://doi.org/10.12968/hmed.2005.66.12.20214
[5]
Kay, J. and Upchurch, K.S. (2012) ACR/EULAR 2010 Rheumatoid Arthritis Classi-Fication Criteria. Rheumatology (Oxford), 51, vi5-vi9. https://doi.org/10.1093/rheumatology/kes279
[6]
Olaru, L., Soong, L., Dhillon, S. and Yacyshyn, E. (2017) Coexistent Rheumatoid Arthritis and Gout: A Case Series and Review of the Literature. Clinical Rheumatology, 36, 2835-2838. https://doi.org/10.1007/s10067-017-3856-6
[7]
Adelowo, O.O. (1986) Tophaceous Gout in a Nigerian with Rheumatoid Arthritis. Scandinavian Journal of Rheumatology, 15, 272-274. https://doi.org/10.3109/03009748609092591
[8]
Kuo, C.-F., Tsai W.-P. and Liou, L.-B. (2008) Rare Copresent Rheumatoid Arthritis and Gout: Comparison with Pure Rheumatoid Arthritis and a Literature Review. Clinical Rheumatology, 27, 231-235. https://doi.org/10.1007/s10067-007-0771-2
[9]
Almoallim, H., et al. (2021) A Review of the Prevalence and Unmet Needs in the Management of Rheumatoid Arthritis in Africa and the Middle East. Rheumatology and Therapy, 8, 1-16. https://doi.org/10.1007/s40744-020-00252-1
[10]
Chakradeo, K., Buzacott, K. and Soden, M. (2016) Nodular Rheumatoid Arthritis Resembling Gout. BMJ Case Reports, 2016, 1-2. https://doi.org/10.1136/bcr-2016-216967
[11]
Haddani, F.Z., Guich, A., Boudhar, E.M., Youssoufi, T. and Hassikou, H. (2020) Association polyarthrite rhumatoïde et goutte: à propos de deux cas. Revue Marocaine de Rhumatologie, 53, 50-52.
[12]
Petsch, C., Araujo, E., Hueber, A., Schett, G., Manger, B. and Rech, J. (2017) Gout Mimicking Rheumatoid Arthritis. Seminars in Arthritis and Rheumatism, 46, e15. https://doi.org/10.1016/j.semarthrit.2016.08.003
[13]
Zhao, G., Wang, X. and Fu, P. (2018) Recognition of Gout in Rheumatoid Arthritis: A Case Report. Medicine (Baltimore), 97, e13540. https://doi.org/10.1097/MD.0000000000013540
[14]
Puszczewicz, M.J. and Ociepa-Zawal, M. (2009) Co-Present Rheumatoid Arthritis and Gout Successfully Treated with Abatacept. Clinical Rheumatology, 28, 105. https://doi.org/10.1007/s10067-008-1030-x