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肠道菌群发酵中药的研究进展
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Abstract:
中药发酵技术以其独特的优势从古传承至今，现代的发酵技术与微生物学、生物工程学、基因学等学科紧密结合，使得发酵机制逐渐成熟，中药发酵的增效减毒作用更加明显，极大地提高了中药发酵的质量。选择适宜的菌种发酵是核心和前提，也是该技术面临的主要问题。肠道菌群符合中药发酵复合菌种的复杂性、自然性及科学性，大量研究证实，中药口服后进入肠道与肠道菌群发生相互作用，进而发挥增效减毒、维持机体稳态的作用。本文基于中药发酵的研究现状、肠道菌群发酵中药的优势所在，提出肠道菌群体外发酵中药的设想，并对该设想面临的问题进行了展望。
With its unique advantages, traditional Chinese medicine fermentation technology has been passed on from ancient times to the present. Modern fermentation technology is closely combined with microbiology, bioengineering, genetics and other disciplines, which makes the fermentation mechanism mature gradually. The synergistic and attenuating effect of traditional Chinese medicine fermentation is more obvious, which greatly improves the quality of traditional Chinese medicine fermentation. The selection of suitable strain fermentation is the core and premise, and it is also the main problem faced by this technology. Intestinal flora is in line with the complexity, natural and scientific nature of traditional Chinese medicine fermentation compound bacteria. A large number of studies have confirmed that traditional Chinese medicine can interact with intestinal flora after oral administration, and then play the role of increasing efficiency and reducing toxicity and maintaining the homeostasis of the body. Based on the research status of traditional Chinese medicine fermentation and the advantages of intestinal flora fermentation of traditional Chinese medicine, this paper puts forward the concept of traditional Chinese medicine fermented by intestinal flora in vitro, and looks forward to the problems faced by this concept.
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