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lncRNA在肺动脉高压血管平滑肌细胞中的作用
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Abstract:
肺动脉高压(pulmonary hypertension, PH)是一种病因复杂的进行性疾病，目前仍无法治愈，其病理特征主要是肺血管明显重构、肺动脉压力升高及右心室肥厚。长链非编码RNA (lncRNA)是一类长度超过200 nt不具有编码蛋白能力的RNA。近年来，越来越多的研究发现lncRNA在PH发生机制中发挥重要作用。抗凋亡、过度增殖和迁移是肺动脉平滑肌细胞(PASMCs)失调导致血管重构的主要机制，而血管重构是PH发病机制的关键因素。本文主要概述在PH中调节PASMCs功能的lncRNA及其作用机制。
Pulmonary hypertension (PH) is a progressive disease with complex etiology, which is still incurable, and its pathological characteristics are mainly significant pulmonary vascular remodeling, elevated pulmonary artery pressure, and right ventricular hypertrophy. Long non-coding RNA (lncRNA) is a class of RNA longer than 200 nt that cannot encode proteins. Recently, more and more studies have found that lncRNA plays an important role in the pathogenesis of PH. Pulmonary vascular remodeling caused by excessive proliferation, migration and anti-apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key in the pathogenesis of PH. This paper mainly reviewed the molecular mechanism of lncRNA regulating PASMCs function and participating in the development of PH.
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