Introduction: Cervical cancer is a public health concern and is mainly caused by Human papillomaviruses (HPV). In many parts of the world, studies are being carried out to understand the different genotypes to better tackle this issue. We conducted a study to determine the prevalence of HPV genotypes in women with chronic hepatitis B or C infection, co-infected or not with HIV, treated at the Hôpital Saint Camille in Ouagadougou (Burkina Faso). Methods: This study was conducted from April to July 2023, including 100 women in gastroenterology at Hôpital Saint Camille. A questionnaire on their socio-demographic and life style was administrated; and endocervical samples were collected using sterile swabs and then sent to Centre of Biomolecular Research Pietro Annigoni (CERBA). HPV molecular detection and genotyping were performed by PCR and hybridization using the HPV Direct Flow Chips kit. Data were analysis using chi square test or Fischer’s exact test with a significance threshold for p < 0.05. Results: The prevalence of HPV infection was 28% (28/100) on the sample of women tested. The most frequent genotypes were HPV 52 (8.33%), followed by HPV 18 and 68 (6.25% each) for high-risk HPVs, and HPV 6, 44/55 and 62/81 (8.33% each) for low-risk HPVs. Conclusion: This study, the first of its kind in Burkina Faso on this group of the population, reveals that the most frequent genotypes found in this study are not included in the vaccine available in Burkina Faso (Gardasil®4).
References
[1]
Reddy, D., Njala, J., Stocker, P., Schooley, A., Flores, M., Tseng, C.H., et al. (2015) High-Risk Human Papilloma-Virus in HIV-Infected Women Undergoing Cervical Cancer Screening in Lilongwe, Malawi: A Pilot Study. International Journal of STD & AIDS, 26, 379-387. https://doi.org/10.1177/0956462414539149
[2]
Kashyap, N., Krishnan, N., Kaur, S. and Ghai, S. (2019) Risk Factors of Cervical Cancer. Asia-Pacific Journal of Oncology Nursing, 6, 308-314.
https://doi.org/10.4103/apjon.apjon_73_18
[3]
Castellsagué, X. (2008) Natural History and Epidemiology of HPV Infection and Cervical Cancer. Gynecologic Oncology, 110, S4-S7.
https://doi.org/10.1016/j.ygyno.2008.07.045
[4]
Bosch, F.X. and De Sanjosé, S. (2007) The Epidemiology of Human Papillomavirus Infection and Cervical Cancer. Disease Markers, 23, 213-227.
https://doi.org/10.1155/2007/914823
[5]
Munoz, N., Bosch, F.X., de Sanjosé, S., Herrero, R., Castellsagué, X., Shah, K.V., et al. (2003) Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer. The New England Journal of Medicine, 348, 518-527.
https://doi.org/10.1056/NEJMoa021641
[6]
GLOBOCAN (2020) Incidence du Cancer au Burkina Faso. Global Cancer Observatory, 927.
[7]
Zohoncon, T.M., Ouedraogo, R.A., Djigma, F.W., Traore, L., Ouedraogo, T.W.C., Ilboudo, M., et al. (2022) Molecular Epidemiology of High-Risk Human Papillomavirus Infection in Burkina Faso. In: Budak, M. and Rajkumar, R., Eds., Molecular Mechanisms in Cancer, IntechOpen, London.
[8]
Kagoné, T.S., Paré, P.G., Dembélé, A., Kania, D., Zida, S., Thiéba, B.B., et al. (2022) Cervical Cancer in the Hauts-Bassins Region of Burkina Faso: Results of a Screening Campaign by Visual Inspection with Acetic Acid (VIA Screening in Burkina Faso). African Journal of Reproductive Health, 26, 97-103.
[9]
Ouedraogo, R.A., Zohoncon, T.M., Ouattara, A.K. and Simpore, J. (2020) Prédominance du papillomavirus humain 56 dans une sous-population de femmes sexuellement actives à Garango, Centre-Est, Burkina Faso. Journal of Applied Biosciences, 150, 15499-15509. https://doi.org/10.35759/JABs.150.10
[10]
Traore, I.M.A., Zohoncon, T.M., Dembele, A., Djigma, F.W., Obiri-Yeboah, D., Traore, G., et al. (2016) Molecular Characterization of High-Risk Human Papillomavirus in Women in Bobo-Dioulasso, Burkina Faso. BioMed Research International, 2016, Article ID: 7092583. https://doi.org/10.1155/2016/7092583
[11]
Tovo, S.F., Zohoncon, T.M., Dabiré, A.M., Ilboudo, R., Tiemtoré, R.Y., Obiri-Yeboah, D., et al. (2021) Molecular Epidemiology of Human Papillomaviruses, Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium among Female Sex Workers in Burkina Faso: Prevalence, Coinfections and Drug Resistance Genes. Tropical Medicine and Infectious Disease, 6, Article 90.
https://doi.org/10.3390/tropicalmed6020090
[12]
Ilboudo, R., Traoré, E., Zohoncon, T., Ouédraogo, R., Traore, I., Bado, P., et al. (2020) Prevalence and Characterization of High-Risk Human Papillomavirus. Genotypes among a Group of Sex Workers in Ouagadougou, Burkina Faso. EC Gynaecology, 9, 1-9.
[13]
Ouedraogo, T., Wendé, C., Djigma, F.W., Idani, B., Zohoncon, T.M., Sorgho, P.A., Bado, P., et al. (2020) Impact of Glutathione S-Transferase Genes Polymorphisms on Human Papillomavirus Infection and Pre-Cancerous Lesions in West African Women. International Journal of Genetics and Molecular Biology, 12, 59-70.
[14]
Kelly, H.A., Sawadogo, B., Chikandiwa, A., Segondy, M., Gilham, C., Lompo, O., et al. (2017) Epidemiology of High-Risk Human Papillomavirus and Cervical Lesions in African Women Living with HIV/AIDS: Effect of Anti-Retroviral Therapy. AIDS, 31, 273-285. https://doi.org/10.1097/QAD.0000000000001301
[15]
Ouédraogo, C., Zohoncon, T.M., Traoré, E.M.A., Ouattara, S., Bado, P., Ouedraogo, C.T., et al. (2016) Distribution of High-Risk Human Papillomavirus Genotypes in Precancerous Cervical Lesions in Ouagadougou, Burkina Faso. Open Journal of Obstetrics and Gynecology, 39, 196-204. https://doi.org/10.4236/ojog.2016.64025
[16]
Sanou-Lamien, A., Ki, R., Zohoncon-Kone, T., Ouedraogo, A., Konsegre, V., Ido, F., et al. (2018) Aspects socio-démographiques et histopathologiques des lésions pré-cancéreuses de haut grade et cancéreuses du col utérin et caractérisation moléculaire des HPV oncogènes impliqués à Ouagadougou (Burkina Faso). Revue Africaine de Pathologie, 17, 48-55.
[17]
Zohoncon, T.M., Bado, P., Ouermi, D., Traoré, E.M.A., Djigma, F.W., Traore, I.M.A., et al. (2016) Molecular Characterization of High-Risk Human Papillomavirus Genotypes Involved in Invasive Cervical Cancer From Formalin-Fixed, Formalin Paraffin-Embedded Tissues in Ouagadougou, Burkina Faso. International Journal of Current Research, 8, 39314-39318.
[18]
Kabre, K.M., Ouermi, D., Zohoncon, T.M., Traore, F.P.W., Gnoumou, O.P.D.P., Ouedraogo, R.A., et al. (2022) Molecular Epidemiology of Human Papillomavirus in Pregnant Women in Burkina Faso. Biomolecular Concepts, 13, 334-340.
https://doi.org/10.1515/bmc-2022-0026
[19]
Ouédraogo, C.M.R., Rahimy, R.M.L., Zohoncon, T.M., Djigma, F.W., Yonli, A.T., Ouermi, D., et al. (2015) épidémiologie et caractérisation des génotypes à haut risque de Papillomavirus humain dans une population d’adolescentes sexuellement actives à Ouagadougou. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 44, 715-722. https://doi.org/10.1016/j.jgyn.2014.12.021
[20]
Djigma, F.W., Ouédraogo, C., Karou, D.S., Sagna, T., Bisseye, C., Zeba, M., et al. (2011) Prevalence and Genotype Characterization of Human Papillomaviruses among HIV-Seropositive in Ouagadougou, Burkina Faso. Acta Tropica, 117, 202-206.
https://doi.org/10.1016/j.actatropica.2010.12.007
[21]
Djigma, F.W., Zohoncon, T.M., Douamba, Z., Sorgho, P.A., Obiri-Yeboah, D., Ouattara, A.K., et al. (2020) Molecular Genotyping of Human Papillomavirus among HIV-Infected and HIV-Uninfected Women in Ouagadougou, Burkina Faso. Journal of Medical Biomedical and Applied Sciences, 8, 324-333.
[22]
Sagna, T., Djigma, F., Zeba, M., Bisseye, C., Karou, S., Ouermi, D., et al. (2010) Human Papillomaviruses Prevalence and Genital Co-Infections in HIV-Seropositive Women in Ouagadougou (Burkina Faso). Pakistan Journal of Biological Sciences, 13, 951-955. https://doi.org/10.3923/pjbs.2010.951.955
[23]
Petrick, J.L. and McGlynn, K.A. (2019) The Changing Epidemiology of Primary Liver Cancer. Current Epidemiology Reports, 6, 104-111.
https://doi.org/10.1007/s40471-019-00188-3
[24]
Meda, N., Tuaillon, E., Kania, D., Tiendrebeogo, A., Pisoni, A., Zida, S., et al. (2018) Hepatitis B and C Virus Seroprevalence, Burkina Faso: A Cross-Sectional Study. Bulletin of the World Health Organization, 96, 750-759.
https://doi.org/10.2471/BLT.18.208603
[25]
Tao, I., Compaoré, T.R., Diarra, B., Djigma, F., Zohoncon, T.M., Assih, M., et al. (2014) Seroepidemiology of Hepatitis B and C Viruses in the General Population of Burkina Faso. Hepatitis Research and Treatment, 2014, Article ID: 781843.
https://doi.org/10.1155/2014/781843
[26]
Luo, C., Yu, S., Zhang, J., Wu, X., Dou, Z., Li, Z., et al. (2022) Hepatitis B or C Viral Infection and the Risk of Cervical Cancer. Infectious Agents and Cancer, 17, Article No. 54. https://doi.org/10.1186/s13027-022-00466-8
[27]
Yelemkoure, E.T., Yonli, A.T., Sombie, H.K., Tao, I., Zouré, A.A., Ouattara, A.K., et al. (2022) Seroprevalence, Genotyping, and Monitoring of Hepatitis C Viral Loads in Patients on Antivirals in Burkina Faso. Intervirology, 65, 151-159.
https://doi.org/10.1159/000519848
[28]
Bomfim-Hyppólito, S., Eleuterio, J., Nunes, G.C., Bomfim-Hyppólito, E., Franco, E.S. and Neto, R.D.J.P. (2013) HIV or Human Papillomavirus Co-Infection among Brazilian Individuals Infected with Hepatitis B and/or Hepatitis C. International Journal of Gynecology & Obstetrics, 122, 258-260.
https://doi.org/10.1016/j.ijgo.2013.04.012
[29]
Lacey, C.J. (2019) HPV Vaccination in HIV Infection. Papillomavirus Research, 8, Article 100174. https://doi.org/10.1016/j.pvr.2019.100174
[30]
Stanley, M.A. and Sterling, J.C. (2014) Host Responses to Infection with Human Papillomavirus. Current Problems in Dermatology, 45, 58-74.
https://doi.org/10.1159/000355964
[31]
Henri, E., Paul, E.J., Roger, E.M., Theophile, N.N., Valere, M.K., Merlin, B., et al. (2020) HIV+ Status and Cervical Cancer: Cytological Aspects of Cervical Smear in Cameroon Setting. Open Journal of Obstetrics and Gynecology, 10, 76-84.
https://doi.org/10.4236/ojog.2020.101007
[32]
Ouedraogo, R.A., Ouedraogo, R.A., Zohoncon, T.M., Zohoncon, T.M., Zohoncon, T.M., Traore, I.M.A., et al. (2020) Genotypic Distribution of Human Oncogenic Papillomaviruses in Sexually Active Women in Burkina Faso: Central, Central-Eastern and Hauts-Bassins Regions. Biomolecular Concepts, 11, 125-136.
https://doi.org/10.1515/bmc-2020-0011
[33]
Bosch, F.X., Lorincz, A., Meijer, C.J.L.M. and Shah, K.V. (2002) The Causal Relation between Human Papilloma-Virus and Cervical Cancer. Journal of Clinical Pathology, 55, 244-265. https://doi.org/10.1136/jcp.55.4.244
[34]
De Sanjose, S., Bosch, F.X., Mufioz, N., Tafur, L., Gili, M., Izarzugaza, I., et al. (1996) Socioeconomic Differences in Cervical Cancer: Two Case-Control Studies in Colombia and Spain. American Journal of Public Health, 86, 1532-1538.
https://doi.org/10.2105/AJPH.86.11.1532
[35]
Munoz, N., Franceschi, S., Bosetti, C., Moreno, V., Herrero, R., Smith, J.S., et al. (2002) Role of Parity and Human Papillomavirus in Cervical Cancer: The IARC Multicentric Case-Control Study. The Lancet, 359, 1093-1101.
https://doi.org/10.1016/S0140-6736(02)08151-5
[36]
Levi, J.E., Longatto-Filho, A., Eluf-Neto, J., Rodrigues, C.L., Oliveira, C.M., Carloni, A.C., et al. (2014) Evaluation of HPV Molecular Tests in Primary Screening for Cervical Cancer in Brazil. Open Journal of Obstetrics and Gynecology, 4, 470-478.
https://doi.org/10.4236/ojog.2014.48068
[37]
Fabiano, V., Mariani, L., Giovagnoli, M.R., Raffa, S., Vincenzoni, C., de Michetti, F., et al. (2010) Cervical Cancer Screening Program Based on HPV Testing and Conventional Papanicolaou Cytology for Jail Inmates. Health, 2, 1027-1032.
https://doi.org/10.4236/health.2010.29151
[38]
Osnytska, Y., Martin, L.R. and Goodman, A. (2023) Cervical Cancer Prevention Challenges and Barriers to Cervical Cancer Screening and HPV Vaccinations in Ukraine and Eastern Europe. Health, 15, 525-543.
https://doi.org/10.4236/health.2023.156036
[39]
Oyervides-Munoz, M.A., Pérez-Maya, A.A., Sánchez-Domínguez, C.N., Berlanga-Garza, A., Antonio-Macedo, M., Valdéz-Chapa, L.D., et al. (2020) Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women. Viruses, 12, Article 380. https://doi.org/10.3390/v12040380
[40]
Bado, P., Djigma, F.W., Zohoncon, T.M., Obiri-Yeboah, D., Traoré, E.M.A., Ouattara, A.K., et al. (2020) Erratum: Polymorphism of MMP1 and MMP3 Promoter Regions and HR-HPV Infection in Women from Burkina Faso and Cote d’Ivoire. BioMolecular Concepts, 11, 142. https://doi.org/10.1515/bmc-2020-0013
[41]
Traore, M.A.E., Djigma, W.F., Setor, M.A., Zohoncon, T.M., Obiri-Yeboah, D., Ouattara, A.K., et al. (2019) Mspi Polymorphisms (rs4646903) of the CYP1A1 Gene in Women Infected with Human Papillomavirus in West Africa. International Journal of Current Research, 11, 8390-8396.
