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Bioprocess 2023
ALKBH5在不同免疫环境中的调控作用
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Abstract:
m6A修饰在转录后水平调控多种细胞过程，而RNA m6A水平受RNA去甲基化酶ALKBH5调节，维持正常的生理功能的同时也促进多种人类疾病发生发展。在这篇综述中，我们讨论了ALKBH5与免疫之间的联系以及在免疫系统和癌症中的多重作用。我们分析了ALKBH5在不同免疫环境中的调节作用，包括促进正常免疫细胞发育成熟和细胞因子释放，在多种肿瘤组织中异常表达对肿瘤免疫微环境的调节和ALKBH5失调促进自身免疫疾病发生等。在不同免疫环境中的诸多调节作用使得ALKBH5可能作为肿瘤免疫、自身免疫性疾病以及在其他与ALKBH5免疫调节相关疾病的潜在药物靶标，为开发免疫治疗药物提供理论参考。
The modification of m6A regulates various cellular processes at post-transcription level. While RNA m6A level is regulated by RNA demethylase ALKBH5, which maintains normal physiological functions and promotes the initiation and development of various human diseases. In this review, we discuss multiple roles of ALKBH5 in immune system and cancers. We summarize the regulatory effects of ALKBH5 in different immune environments, including promotion of normal immune cells maturation and cytokines release, regulation of tumor immune microenvironment in a variety of tumor tissues, and initiation of autoimmune diseases by abnormal expression of ALKBH5. Due to its various roles in different immune environments, ALKBH5 may serve as a potential drug target for tumor immunity, autoimmune diseases and other diseases related to ALKBH5, providing a theoretical basis for developing immunotherapeutic drugs.
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