Protective and Regenerative Anti-Pollution Efficacy of a Plant Oil-Based Day and Night Cream: Investigated by a Novel Approach to Reveal the Impact of Pollutants on Epidermal Barrier Integrity and Lipid Matrix
In the
wake of ever-increasing environmental pollution, human skin in the modern urban
world is exposed to increased levels of harmful environmental pollutants. Many
studies have shown that these pollutants can weaken the epidermal skin barrier
and thus facilitate the penetration of these substances into the skin. An
important goal of modern skin care against harmful environmental influences
should therefore be to protect and strengthen the epidermal barrier and to
repair occurring damage quickly and efficiently. With this in mind, in the present study we investigated what
damage cigarette smoke causes to the epidermal barrier and 1) whether the regular application of a O/W emulsion (Day Cream) can
protectively strengthen the epidermal barrier against environmental damage and 2) whether a cigarette smoke-induced disruption of the epidermal barrier is restored faster and
better by the regular application of a another O/W emulsion (Night Cream) than
in product-untreated skin. The two products are slightly different in
plant-oil, active ingredient composition and texture. Firstly, the study has
shown that the Lipbarvis? method is suitable for measuring the effect of cigarette smoke,
in contrast to conventional biophysical measurement methods (transepidermal
water loss, skin hydration). Secondly, both products were able to improve skin
barrier function in the corresponding test scenario. This was demonstrated for
both test products by a significantly reduced TEWL, significantly increased
skin hydration and significantly improved
length of the lipid lamellae in the intercellular space, as well as the protective effect of the day cream on the
epidermal skin barrier and the regenerative properties of the tested night cream.
References
[1]
Elias, P.M. and Choi, E.H. (2005) Interactions among Stratum Corneum Defensive Functions. Experimental Dermatology, 14, 719-726. https://doi.org/10.1111/j.1600-0625.2005.00363.x
[2]
Rembiesa, J., Ruzgas, T., Engblom, J. and Holefors, A. (2018) The Impact of Pollution on Skin and Proper Efficacy Testing for Anti-Pollution-Claims. Cosmetics, 5, Article No. 4. https://doi.org/10.3390/cosmetics5010004
[3]
Drakaki, E., Dessinioti, C. and Antoniou, C. (2014) Air Pollution and the Skin. Frontiers in Environmental Science, 2, Article No. 11. https://doi.org/10.3389/fenvs.2014.00011
[4]
Baudouin, C., Charveron, M., Tarroux, R. and Gall, Y. (2002) Environmental Pollutants and Skin Cancer. Cell Biology and Toxicology, 18, 341-348. https://doi.org/10.1023/A:1019540316060
[5]
Ortiz, A. and Grando, A.G. (2012) Smoking and the Skin. International Journal of Dermatology, 51, 250-262. https://doi.org/10.1111/j.1365-4632.2011.05205.x
[6]
Morita, A. (2007) Tobacco Smoke Causes Premature Skin Aging. Journal of Dermatological Science, 48, 169-175. https://doi.org/10.1016/j.jdermsci.2007.06.015
[7]
WHO (2022) Ambient Air Pollution Data. Verfügbar Unter. https://www.who.int/data/gho/data/themes/air-pollution/ambient-air-pollution
[8]
Koohgoli, R., Hudson, L., Naidoo, K., Wilkinson, S., Chavan, B. and Birch-Machin, M.A. (2017) Bad Air Gets under Your Skin. Experimental Dermatology, 26, 384-387. https://doi.org/10.1111/exd.13257
[9]
Kim, K.E., Cho, D. and Park, H.J. (2016) Air Pollution and Skin Diseases: Adverse Effects of Airborne Particulate Matter on Various Skin Diseases. Life Sciences, 152, 126-134. https://doi.org/10.1016/j.lfs.2016.03.039
[10]
Armstrong, A.W., Harskamp, C.T. and Dhillon, J.S. (2014) Psoriasis and Smoking: A Systematic Review and Meta-Analysis. British Journal of Dermatology, 170, 304-314. https://doi.org/10.1111/bjd.12670
[11]
Armstrong, A.W., Armstrong, E.J., Fuller, E.N., Sockolov, M.E. and Voyles, S.V. (2011) Smoking and Pathogenesis of Psoriasis: A Review of Oxidative, Inflammatory and Genetic Mechanisms. British Journal of Dermatology, 165, 1162-1168. https://doi.org/10.1111/j.1365-2133.2011.10526.x
[12]
Krutmann, J., Moyal, D., Liu, W., Lee, G.-S., Nopadon, N. and Xiang, L.F. (2017) Pollution and Acne: Is There a Link? Clinical, Cosmetic and Investigational Dermatology, 10, 199-204. https://doi.org/10.2147/CCID.S131323
[13]
Araviiskaia, E., Berardesca, E., Bieber, T., Gontijo, G., Sanchez Viera, M., Marrot, L., Chuberre, B. and Dreno, B. (2019) The Impact of Airborne Pollution on Skin. Journal of the European Academy of Dermatology and Venereology, 33, 1496-1505. https://doi.org/10.1111/jdv.15583
[14]
Valacchi, G., Porada, E. and Rowe, B.H. (2015) Ambient Ozone and Bacterium streptococcus: A Link between Cellulitis and Pharyngitis. International Journal of Occupational Medicine and Environmental Health, 28, 771-774. https://doi.org/10.13075/ijomeh.1896.00267
[15]
Proksch, E., Brandner, J.M. and Jensen, J.M. (2008) The Skin: An Indispensable Barrier. Experimental Dermatology, 17, 1063-1072. https://doi.org/10.1111/j.1600-0625.2008.00786.x
[16]
Birch-Machin, M.A. and Bowman, A. (2016) Oxidative Stress and Ageing. British Journal of Dermatology, 175, 26-29. https://doi.org/10.1111/bjd.14906
[17]
Ghio, A.J., Carraway, M.S. and Madden, M.C. (2012) Composition of Air Pollution Particles and Oxidative Stress in Cells, Tissues, and Living Systems. The Journal of Toxicology and Environmental Health: Part B, Critical Reviews, 15, 1-21. https://doi.org/10.1080/10937404.2012.632359
[18]
Puri, P., Nandar, S.K., Kathuria, S. and Ramesh, V. (2017) Effects of Air Pollution on the Skin: A Review. Indian Journal of Dermatology, Venereology and Leprology, 83, 415-423. https://doi.org/10.4103/0378-6323.199579
[19]
Kim, B.E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K.A., Lee, U.H., Han, S., Leung, S., Hall, C.F., Kim, N.R., Bronova, I., Lee, E.J., Yang, H.R., Leung, D.Y. and Ahn, K. (2021) Particulate Matter Causes Skin Barrier Dysfunction. JCI Insight, 6, e145185. https://doi.org/10.1172/jci.insight.145185
[20]
Lee, C.W., Lin, Z.C., Hu, S.C., Chiang, Y.C., Hsu, L.F., Lin, Y.C., Lee, I.T., Tsai, M.H. and Fang, J.Y. (2016) Urban Particulate Matter Down-Regulates Filaggrin via COX2 Expression/PGE2 Production Leading to Skin Barrier Dysfunction. Scientific Reports, 6, Article No. 27995. https://doi.org/10.1038/srep27995
[21]
Percoco, G., Patatian, A., Eudier, F., Grisel, M., Bader, T., Lati, E., Savary, G., Picard, C. and Benech, P. (2021) Impact of Cigarette Smoke on Physical-Chemical and Molecular Proprieties of Human Skin in an Ex Vivo Model. Experimental Dermatology, 30, 1610-1618. https://doi.org/10.1111/exd.14192
[22]
Hergesell, K., Paraskevopoulou, A., Opálka, L., Velebny, V., Vávrová, K. and Dolečková, I. (2023) The Effect of Long-Term Cigarette Smoking on Selected Skin Barrier Proteins and Lipids. Scientific Reports, 13, Article No. 11572. https://doi.org/10.1038/s41598-023-38178-7
[23]
Krutmann, J., Liu, W., Li, L., Pan, X., Crawford, M. and Sore, G. (2014) Pollution and Skin: From Epidemiological and Mechanistic Studies to Clinical Implications. Journal of Dermatological Science, 76, 163-168. https://doi.org/10.1016/j.jdermsci.2014.08.008
[24]
Bielfeldt, S., Böhling, A., Laing, S., Hoppe, C. and Wilhelm, K.P. (2016) Environmental Skin Protection Strategies—A New Clinical Testing Method Employing a Cigarette Smoke Pollutant Model. SOFW, 142, 10-17.
[25]
Lee, J., Oh, S.J., Park, S., Park, J.-H. and Lee, J.H. (2021) Anti-Pollution Skincare: Research on Effective Ways to Protect Skin from Particulate Matter. Dermatologic Therapy, 34, e14960. https://doi.org/10.1111/dth.14960
[26]
Lin, Z., Niu, Y., Jiang, Y., Chen, B., Peng, L., Mi, T., Huang, N., Li, W., Xu, D., Chen, R. and Kan, H. (2021) Protective Effects of Dietary Fish-Oil Supplementation on Skin Inflammatory and Oxidative Stress Biomarkers Induced by Fine Particulate Air Pollution: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial. British Journal of Dermatology, 184, 261-269. https://doi.org/10.1111/bjd.19156
[27]
Milani, M., Hashtroody, B., Piacentini, M. and Celleno, L. (2019) Skin Protective Effects of an Antipollution, Antioxidant Serum Containing Deschampsia antartica Extract, Ferulic Acid and Vitamin C: A Controlled Single-Blind, Prospective Trial in Women Living in Urbanized, High Air Pollution Area. Clinical, Cosmetic and Investigational Dermatology, 12, 393-399. https://doi.org/10.2147/CCID.S204905
[28]
Ditgen, D., Segger, D., Klaucke, J., von Seebach, A., Dähnhardt, D., Dähnhardt-Pfeiffer, S., Westphal, D. and Degwert, J. (2022) Effects of Cigarette Smoke on the Skin in Comparison to UV Radiation: Parallels and Differences. Euro Cosmetics, 3, 24-30.
[29]
Bielfeldt, S., Jung, K., Laing, S., Moga, A. and Wilhelm, K.P. (2021) Anti-Pollution Effects of Two Antioxidants and a Chelator-ex Vivo Electron Spin Resonance and in Vivo Cigarette Smoke Model Assessments in Human Skin. Skin Research and Technology, 27, 1092-1099. https://doi.org/10.1111/srt.13068
[30]
Rogiers, V. (2001) EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences. Skin Pharmacology and Applied Skin Physiology, 14, 117-128. https://doi.org/10.1159/000056341
[31]
Berardesca, E. (1997) EEMCO Guidance for the Assessment of Stratum Corneum Hydration: Electrical Method. Skin Research and Technology, 3, 126-132. https://doi.org/10.1111/j.1600-0846.1997.tb00174.x
[32]
Blaak, J., Dähnhardt, D., Bielfeldt, S., Theiss, C., Simon, I., Wilhelm, K.-P., Dähnhardt-Pfeiffer, S. and Staib, P. (2023) Improvement of Human Epidermal Barrier Structure and Lipid Profile in Xerotic- and Atopic-Prone Skin via Application of a Plant-Oil and Urea Containing pH 4.5 Emulsion. Cosmetics, 10, Article No. 95. https://doi.org/10.3390/cosmetics10040095
[33]
Blaak, J., Dähnhardt, D., Dähnhardt-Pfeiffer, S., Bielfeldt, S., Wilhelm, K.-P., Wohlfart, R. and Staib, P. (2017) A Plant Oil-Containing pH4 Emulsion Improves Epidermal Barrier Structure and Enhances Ceramide Levels in Aged Skin. International Journal of Cosmetic Science, 39, 284-91. https://doi.org/10.1111/ics.12374
[34]
Dähnhardt-Pfeiffer, S., Surber, C., Wilhelm, K.-P., Dähnhardt, D., Springmann, G., Boettcher, M. and Foelster-Holst, R. (2012) Noninvasive Stratum Corneum Sampling and Electron Microscopical Examination of Skin Barrier Integrity: Pilot Study with a Topical Glycerin Formulation for Atopic Dermatitis. Skin Pharmacology and Physiology, 25, 155-161. https://doi.org/10.1159/000336789
[35]
Krutmann, J. (2019) Luftverschmutzung und Haut. Hautarzt, 70, 156-157. https://doi.org/10.1007/s00105-018-4349-5
[36]
Vierkötter, A., Schikowski, T., Ranft, U., Sugiri, D., Matsui, M., Krämer, U. and Krutmann, J. (2010) Airborne Particle Exposure and Extrinsic Skin Aging. Journal of Investigative Dermatology, 130, 2719-2726. https://doi.org/10.1038/jid.2010.204
[37]
Dähnhardt, D., Surber, C. and Dähnhardt-Pfeiffer, S. (2018) Influence of Topical Formulations: Lipid Lamella Organization and Lipid Composition of Stratum Corneum as a Surrogate Marker for Barrier Integrity. Current Problems in Dermatology, 54, 166-172. https://doi.org/10.1159/000489530
[38]
Lademann, J., Vergou, T., Darvin, M.E., Patzelt, A., Meinke M.C., Voit, C., Papakostas, D., Zastrow, L., Sterry, W. and Doucet, O. (2016) Influence of Topical, Systemic and Combined Application of Antioxidants on the Barrier Properties of the Human Skin. Skin Pharmacology and Physiology, 29, 41-46. https://doi.org/10.1159/000441953
[39]
Proksch, E., de Bony, R., Trapp, S. and Boudon, S. (2017) Topical Use of Dexpanthenol: A 70th Anniversary Article. Journal of Dermatological Treatment, 28, 766-773. https://doi.org/10.1080/09546634.2017.1325310
[40]
Blaak, J. and Staib, P. (2022) An Updated Review on Efficacy and Benefits of Sweet Almond, Evening Primrose and Jojoba Oils in Skin Care Applications. International Journal of Cosmetic Science, 44, 1-9. https://doi.org/10.1111/ics.12758
