Context: Breast cancer is very deadly among women with higher rates in the developing world. Imaging tools such as ultrasound, can be used to differentiate between the types of breast lumps. This study aimed to determine the value of ultrasound as a first-line examination in the diagnosis of breast masses. Methods: This was a retrospective cross-sectional study of women presenting with breast lumps from November 2022 to June 2023 at the Yaounde General Hospital, which lasted seven months, from November 2022 to June 2023. The sampling was exhaustive and consecutive. Association between variables was studied using the x2 test and concordance between ultrasound and histopathological findings was assessed using the Kappa correlation coefficient. Results: 234 women were included in the study. Their mean age was 46.3 ± 11.4 years. Overall, 15 (6.4%) lumps were benign while 219 (93.6%) were malignant. Triple negative (5.6%) was the most recurrent genomic classification. The correlation between the ultrasound and histopathological findings was significant, with an observed concordance rate at 85.1%, kappa = 0.322 and a p-value < 0.001. Conclusion: The performance of ultrasound in differentiating benign and malignant lesion was high. However, the discordant cases highlight the need for a diagnosis system which blends histopathological and radiological findings for an improved management of patients with breast lumps.
References
[1]
Schmidt, G., Findeklee, S., del Sol Martinez, G., Georgescu, M.T., Gerlinger, C., Nemat, S., Klamminger, G.G., Nigdelis, M.P., Solomayer, E.F. and Hamoud, B.H. (2023) Accuracy of Breast Ultrasonography and Mammography in Comparison with Postoperative Histopathology in Breast Cancer Patients after Neoadjuvant Chemotherapy. Diagnostics, 13, Article No. 2811. https://doi.org/10.3390/diagnostics13172811
[2]
Tagne Simo, R., Baiguerel, E.M., Nwabo Kamdje, A.H., Seke Etet, P.F., Ahmadou, M., Nangue, C. and Telefo, P.B. (2021) Awareness of Breast Cancer Screening among the Medical and General Population of the North Region of Cameroon. International Journal of Breast Cancer, 2021, Article ID: 6663195. https://doi.org/10.1155/2021/6663195
[3]
Ndoua, C.C.N., Motolouze, K., Etienne, A., Ntsama, J.A.M., Rs, T.N., Tatsipie, W.L., Lc, F.F., Felix, E., Esther, M. and Pascal, F. (2022) Survival of Patients Operated on for Breast Cancer in Yaounde: A Study of 166 Cases. Health Sciences and Disease, 23, 27-30. https://www.hsd-fmsb.org/index.php/hsd/article/view/3871
[4]
Akinnibosun-Raji, H.O., Saidu, S.A., Mustapha, Z., Ma’aji, S.M., Umar, M., Kabir, F.U., Udochukwu, U.G., Garba, K.J. and Raji, M.O. (2022) Correlation of Sonographic Findings and Histopathological Diagnoses in Women Presenting with Breast Masses. Journal of West African College of Surgeons, 12, 109-114. https://doi.org/10.4103/jwas.jwas_84_22
[5]
Odedina, S.O., Ajayi, I.O., Adeniji-Sofoluwe, A., Morhason-Bello, I.O., Huo, D., Olopade, O.I. and Ojengbede, O.A. (2018) A Longitudinal Study of the Prevalence and Characteristics of Breast Disorders Detected by Clinical Breast Examination during Pregnancy and Six Months Postpartum in Ibadan, Southwestern Nigeria. BMC Women’s Health, 18, Article No. 152. https://doi.org/10.1186/s12905-018-0647-4
[6]
Elsaeid, Y.M., Elmetwally, D. and Eteba, S.M. (2019) Association between Ultrasound Findings, Tumour Type, Grade, and Biological Markers in Patients with Breast Cancer. Egyptian Journal of Radiology and Nuclear Medicine, 50, Article No. 53. https://doi.org/10.1186/s43055-019-0048-1
[7]
Ghaemian, N., Haji Ghazi Tehrani, N. and Nabahati, M. (2021) Accuracy of Mammography and Ultrasonography and Their BI-RADS in Detection of Breast Malignancy. Caspian Journal of Internal Medicine, 12, 573-579.
[8]
Eren, H., Soylemez Akkurt, T., Izol Ozmen, H., Nazli, M.A., Sen, E., Arikan, S. and Pehlivanoglu, B. (2022) Ultrasound-Guided Breast Biopsy: Evaluation of the Correlation between Radiologic and Histopathologic Findings. Cam & Sakura Medical Journal, 2, 70-74. https://doi.org/10.4274/csmedj.galenos.2022.2021-12-5
[9]
Bello, N., Olarinoye-Akorede, S.A., Mohammed, H.M., Aliyu, I., Abdullahi, M.Z., Ibrahim, M.Z., Lawal, S. and Rasheed, M.H. (2023) The Correlation of Sonographic and Histopathologic Findings in the Diagnosis of Palpable Breast Masses in Zaria. Journal of West African College of Surgeons, 13, 74-78. https://doi.org/10.4103/jwas.jwas_218_22
[10]
Jahan, A.B., Ahmed, M.U., Begum, M., Hossain, M.M., Rahman, M.M., Sarwar, J.M., Hossain, M.Z., Begum, F., Saha, P.L., Haque, S. and Muktadira, M. (2017) Ultrasonographic Evaluation of Palpable Breast Mass and Correlation with Histopathology. Mymensingh Medical Journal, 26, 223-229.
[11]
Kapoor, B., Vaid, P., Kapoor, M., Kapoor, B. and Kapoor, S. (2020) Clinical, Radiological and Pathological Correlation in Benign Breast Diseases in Women. International Journal of Medical Reviews and Case Reports, 4, 6-12. https://doi.org/10.5455/IJMRCR.Clinical-Radiological-and-Pathological-correlation-benign-breast-diseases-women
[12]
Sarangan, A., Geetha, R., Raj, S. and Pushpa, B. (2017) Study of Histopathological Correlation of Breast Mass with Radiological and Cytological Findings. IOSR Journal of Dental and Medical Sciences, 16, 1-7. https://doi.org/10.9790/0853-1603090107
[13]
Nguefack, C.T., Biwole, M.E., Massom, A., Kamgaing, J.T., Njamen, T.N., Ekane, G.H., Obinchemti, T.E. and Priso, E.B. (2012) Epidemiology and Surgical Management of Breast Cancer in Gynecological Department of Douala General Hospital. The Pan African Medical Journal, 13, Article No. 35.
[14]
Roostaee, A., Soleimani, M., Younesi, L., Poornia, S.M. and Lima, Z.S. (2022) Determining the Relative Frequency of Ultrasound Findings in Women under 30 Years of Age with a Breast Mass. Journal of Family Medicine and Primary Care, 11, 5442-5446. https://doi.org/10.4103/jfmpc.jfmpc_2171_21
[15]
Calas, M.J.G., Koch, H.A. and Dutra, M.V.P. (2007) Breast Ultrasound: Evaluation of Echographic Criteria for Differentiation of Breast Lesions. Radiologia Brasileira, 40, 1-7.
[16]
Atangana, P.J., Nguefack, C.T., Fotsing, C.T., Bell, E.D., Tayou, R., Tomfeu, C.N., Engoumou, A.S., Njimah, A.N., Sando, Z. and Fewou, A. (2017) Aspects Immunohistochimiques des Cancers du Sein à Douala et à Yaounde. Health Sciences and Disease, 18, 14-20. https://www.hsd-fmsb.org/index.php/hsd/article/view/859
[17]
Aziz, S., Mohamad, M.A. and Md Zin, R.R. (2022) Histopathological Correlation of Breast Carcinoma with Breast Imaging-Reporting and Data System. Malaysian Journal of Medical Sciences, 29, 65-74. https://doi.org/10.21315/mjms2022.29.4.7
[18]
Ahmed Abd El-Aleem, M.M., Kadry El-Gendy, M., Salah El-Din Abd El-Baky, M. and Mostafa, O. (2023) Role of Ultrasound Findings and Histopathological Data from Ultrasound Guided Trucut Biopsy in Diagnosis of Suspicious Breast Masses. Al-Azhar Medical Journal, 52, 13-24. https://doi.org/10.21608/amj.2023.273675
[19]
Mubuuke, A.G., Nassanga, R. and Galukande, M. (2023) Comparative Accuracy of Sonography, Mammography and the BI-RADS Characterization of Breast Masses among Adult Women at Mulago Hospital, Uganda. Journal of Global Health Reports, 7, e2023013. https://doi.org/10.29392/001c.75139
[20]
Pereira, R.D.O., Luz, L.A.D., Chagas, D.C., Amorim, J.R., Nery-Júnior, E.D.J., Alves, A.C.B.R., Abreu-Neto, F.T.D., Oliveira, M.D.C.B., Silva, D.R.C., Soares-Júnior, J.M. and Silva, B.B.D. (2020) Evaluation of the Accuracy of Mammography, Ultrasound and Magnetic Resonance Imaging in Suspect Breast Lesions. Clinics, 75, e1805. https://doi.org/10.6061/clinics/2020/e1805
[21]
Ali, E.A., Ahmed, A.M. and Elsaid, N.A. (2020) The Added Advantage of Automated Breast Ultrasound to Mammographically Detected Different Breast Lesions in Patients with Dense Breasts. Egyptian Journal of Radiology and Nuclear Medicine, 51, Article No. 59. https://doi.org/10.1186/s43055-020-00171-9
[22]
Thomas, R., Das, S.K., Balasubramanian, G. and Chandrappa, A. (2022) Correlation of Mammography, Ultrasound and Sonoelastographic Findings with Histopathological Diagnosis in Breast Lesions. Cureus, 14, e32318.
[23]
Christina and Angel, E. (2021) Radiological and Cytological Correlation of Breast Lesions with Histopathology: A Study in a Tertiary Care Centre. International Journal of Clinical and Diagnostic Pathology, 4, 170-173. https://doi.org/10.33545/pathol.2021.v4.i1c.344
[24]
Elverici, E., Barça, A.N., Aktaş, H., Özsoy, A., Zengin, B., Çavuşoğlu, M. and Araz, L. (2015) Nonpalpable BI-RADS 4 Breast Lesions: Sonographic Findings and Pathology Correlation. Diagnostic and Interventional Radiology, 21, 189-194. https://doi.org/10.5152/dir.2014.14103
[25]
Lu, Z., Hao, C., Pan, Y., Mao, N., Wang, X. and Yin, X. (2020) Contrast-Enhanced Spectral Mammography versus Ultrasonography: Diagnostic Performance in Symptomatic Patients with Dense Breasts. Korean Journal of Radiology, 21, 442-449. https://doi.org/10.3348/kjr.2019.0393
[26]
Alikhassi, A., Omranipour, R., Shahriyaran, S., Hadji, M., Abdi, A. and Alikhassy, Z. (2015) Correlation between Imaging and Pathologic Measurement of Breast Cancer Tumour Size. Archives of Breast Cancer, 2, 64-68.
[27]
Ghafoor, L., Hajian, A., Hamidian, Y. and Rohani, S.H. (2020) Concordance and Diagnostic Accuracy of Ultrasonography and Mammography Findings with Pathology Results in Breast Cancer. Archives of Breast Cancer, 7, 127-131.
[28]
Humayun, S., Asif, M., Khadim, M.T., Din, H.U., Anwar, M. and Rashid, F. (2022) Comparison of Breast Biopsy Pathology Reporting with Breast Imaging Reporting and Data System (Bi-Rads) Categories—An Institutional Study. Pakistan Armed Forces Medical Journal, 72, S186-S190. https://doi.org/10.51253/pafmj.v72iSUPPL-2.3496
