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洛尔类药物预防LASIK术后屈光回退的Meta分析
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Abstract:
目的：评估噻吗洛尔、卡替洛尔降眼压预防LASIK术后屈光回退的有效性。方法：运用Reviews Manager 5.3对术后裸眼视力、屈光度、等效球镜度、眼压、角膜曲率、角膜厚度、diff值等数据进行meta分析。结果：纳入13篇文献，共1532例2443眼。Meta分析结果显示：与对照组相比，试验组裸眼视力更佳(MD = ？0.05, 95% CI (？0.06, ？0.04))，屈光度更小(MD = 0.56, 95% CI (0.52, 0.60))，等效球镜度数更低(MD = 0.24, 95% CI (0.18, 0.29))，眼压较低(MD = ？1.09, 95% CI: (？1.72, ？0.45))，角膜曲率更低(MD = ？0.22, 95% CI (？0.36, ？0.09))，角膜厚度无明显差异(MD = ？1.52, 95% CI (？5.78, 2.74))，diff值更小(MD = ？10.47, 95% CI (？11.32, ？9.62))。结论：洛尔类降眼压药物对预防LASIK术后屈光回退确有疗效。
OBJECTIVE: To evaluate the effectiveness of timolol and carteolol in lowering intraocular pressure to prevent refractive regression after LASIK. METHODS: Meta-analysis of the data on postoperative naked-eye visual acuity, refraction, equivalent spherical lens degree, intraocular pressure, corneal curvature, corneal thickness, and diff value was performed using Reviews Manager 5.3. RESULTS: Thirteen papers with 1532 cases and 2443 eyes were included. Meta-analysis showed that com-pared with the control group, the test group had better naked-eye visual acuity (MD = ？0.05, 95% CI (？0.06, ？0.04)), smaller refractive error (MD = 0.56, 95% CI (0.52, 0.60)), and lower equivalent spherical lens diopters (MD = 0.24, and 95% CI (0.18, 0.29)), lower IOP (MD = ？1.09, 95% CI: (？1.72, ？0.45)), lower corneal curvature (MD = ？0.22, 95% CI (？0.36, ？0.09)), and no significant difference in corneal thickness (MD = ？1.52, 95% CI (？5.78, 2.74)), the diff value was smaller (MD = ？10.47, 95% CI (？11.32, ？9.62)). CONCLUSION: Loroidal IOP-lowering drugs are indeed efficacious in preventing refractive regression after LASIK.
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