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癫痫共患抑郁、焦虑相关机制的研究进展
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Abstract:
近年来，癫痫共患病正在逐渐引起重视，其中癫痫共患抑郁、焦虑的发病率则高于其他精神疾病，且癫痫患者共患抑郁、焦虑将显著增加疾病负担、降低生活质量。目前研究发现，癫痫与抑郁、焦虑之间可能存在一些双向关系及共同的病理生理机制。本文将对此进行综述。
In recent years, epilepsy co-morbidities are gradually attracting attention, in which the prevalence of epilepsy co-morbid depression and anxiety is higher than that of other psychiatric disorders, and co-morbid depression and anxiety in epileptic patients will significantly increase the burden of dis-ease and reduce the quality of life. Current research has revealed that there may be some bidirec-tional relationships and common pathophysiological mechanisms between epilepsy and depression and anxiety. This article will review this issue.
| [1] | GBD 2016 Healthcare Access and Quality Collaborators (2018) Measuring Performance on the Healthcare Access and Quality Index for 195 Countries and Territories and Selected Subnational Locations: A Systematic Analysis from the Global Burden of Disease Study 2016. The Lancet (London, England), 391, 2236-2271.
https://doi.org/10.1016/S0140-6736(18)30994-2 |
| [2] | Rashid, H., Upadhyay, A., Pandey, R., et al. (2021) Point Prevalence of Depression in Persons with Active Epilepsy and Impact of Methodological Moderators: A Systematic Re-view and Meta-Analysis. Epilepsy & Behavior: E&B, 125, Article ID: 108394. https://doi.org/10.1016/j.yebeh.2021.108394 |
| [3] | 唐颖莹, 陆璐, 周东. 中国癫痫诊断治疗现状[J]. 癫痫杂志, 2019, 5(3): 161-164. |
| [4] | 李劲梅. 癫痫伴抑郁诊断治疗的中国专家共识(2022修订版) [J]. 癫痫杂志, 2022, 8(6): 488-493. |
| [5] | Giambarberi, L. and Munger, C.H. (2022) Suicide and Epilepsy. Current Neurology and Neuroscience Reports, 22, 441-450. https://doi.org/10.1007/s11910-022-01206-6 |
| [6] | Kanner, A. (2016) Most Antidepressant Drugs Are Safe for Patients with Epilepsy at Therapeutic Doses: A Review of the Evidence. Epilepsy & Behavior: E&B, 61, 282-286. https://doi.org/10.1016/j.yebeh.2016.03.022 |
| [7] | Salpekar, J., Basu, T., Thangaraj, S., et al. (2020) The Intersections of Stress, Anxiety and Epilepsy. International Review of Neurobiology, 152, 195-219. https://doi.org/10.1016/bs.irn.2020.02.001 |
| [8] | Forsgren, L. and Nystr？m, L. (1990) An Incident Case-Referent Study of Epileptic Seizures in Adults. Epilepsy Research, 6, 66-81. https://doi.org/10.1016/0920-1211(90)90010-S |
| [9] | Hesdorffer, D., Ishihara, L., Mynepalli, L., et al. (2012) Epi-lepsy, Suicidality, and Psychiatric Disorders: A Bidirectional Association. Annals of Neurology, 72, 184-191. https://doi.org/10.1002/ana.23601 |
| [10] | Forthoffer, N., Tarrada, A., Brissart, H., et al. (2021) Anxiety and Depres-sion in Newly Diagnosed Epilepsy: A Matter of Psychological History? Frontiers in Neurology, 12, Article ID: 744377. https://doi.org/10.3389/fneur.2021.744377 |
| [11] | Kanner, A. (2012) Can Neurobiological Pathogenic Mechanisms of Depression Facilitate the Development of Seizure Disorders? The Lancet Neurology, 11, 1093-1102. https://doi.org/10.1016/S1474-4422(12)70201-6 |
| [12] | Kanner, A. (2016) Management of Psychiatric and Neuro-logical Comorbidities in Epilepsy. Nature Reviews Neurology, 12, 106-116. https://doi.org/10.1038/nrneurol.2015.243 |
| [13] | Jones, N., Salzberg, M., Kumar, G., et al. (2008) Elevated Anxiety and Depressive-Like Behavior in a Rat Model of Genetic Generalized Epilepsy Suggesting Common Causation. Experi-mental Neurology, 209, 254-260.
https://doi.org/10.1016/j.expneurol.2007.09.026 |
| [14] | Aguilar, B., Malkova, L., N’gouemo, P., et al. (2018) Genet-ically Epilepsy-Prone Rats Display Anxiety-Like Behaviors and Neuropsychiatric Comorbidities of Epilepsy. Frontiers in Neurology, 9, Article No. 476.
https://doi.org/10.3389/fneur.2018.00476 |
| [15] | Samsonsen, C., Mestvedthagen, G., Uglem, M., et al. (2023) Dis-entangling the Cascade of Seizure Precipitants: A Prospective Observational Study. Epilepsy & Behavior: E&B, 145, Ar-ticle ID: 109339.
https://doi.org/10.1016/j.yebeh.2023.109339 |
| [16] | Balamurugan, E., Aggarwal, M., Lamba, A., et al. (2013) Per-ceived Trigger Factors of Seizures in Persons with Epilepsy. Seizure, 22, 743-747. https://doi.org/10.1016/j.seizure.2013.05.018 |
| [17] | Berkhout, J., Walter, D. and Adey, W. (1969) Alterations of the Human Electroencephalogram Induced by Stressful Verbal Activity. Electroencephalography and Clinical Neurophysi-ology, 27, 457-469.
https://doi.org/10.1016/0013-4694(69)90186-2 |
| [18] | Torres-Berrío, A., Issler, O., Parise, E., et al. (2019) Unravel-ing the Epigenetic Landscape of Depression: Focus on Early Life Stress. Dialogues in Clinical Neuroscience, 21, 341-357. https://doi.org/10.31887/DCNS.2019.21.4/enestler |
| [19] | Herbison, C., Allen, K., Robinson, M., et al. (2017) The Impact of Life Stress on Adult Depression and Anxiety Is Dependent on Gender and Timing of Exposure. Development and Psychopathology, 29, 1443-1454.
https://doi.org/10.1017/S0954579417000372 |
| [20] | Plante, D. (2021) The Evolving Nexus of Sleep and Depression. The American Journal of Psychiatry, 178, 896-902.
https://doi.org/10.1176/appi.ajp.2021.21080821 |
| [21] | Dell, K., Payne, D., Kremen, V., et al. (2021) Seizure Likeli-hood Varies with Day-to-Day Variations in Sleep Duration in Patients with Refractory Focal Epilepsy: A Longitudinal Electroencephalography Investigation. EClinicalMedicine, 37, Article ID: 100934. https://doi.org/10.1016/j.eclinm.2021.100934 |
| [22] | Xu, C., Xiong, Q., Tian, X., et al. (2022) Alcohol Exposure In-duces Depressive and Anxiety-Like Behaviors via Activating Ferroptosis in Mice. International Journal of Molecular Sciences, 23, Article No. 13828.
https://doi.org/10.3390/ijms232213828 |
| [23] | Zhang, L., Zhang, H., Lv, L., et al. (2022) A Randomised, Dou-ble-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Lamotrigine in the Maintenance Treatment of Chinese Adult Patients with Bipolar I Disorder. International Journal of Bipolar Disorders, 10, Article No. 20. https://doi.org/10.1186/s40345-022-00266-4 |
| [24] | Ahmed, S., Bachu, R., Kotapati, P., et al. (2019) Use of Gabapentin in the Treatment of Substance Use and Psychiatric Disorders: A Systematic Review. Frontiers in Psychiatry, 10, Article No. 228.
https://doi.org/10.3389/fpsyt.2019.00228 |
| [25] | Mazza, M., Della Marca, G., Di Nicola, M., et al. (2007) Oxcarba-zepine Improves Mood in Patients with Epilepsy. Epilepsy & Behavior: E&B, 10, 397-401. https://doi.org/10.1016/j.yebeh.2007.01.003 |
| [26] | Giorgi, F., Ferrucci, M., Lazzeri, G., et al. (2003) A Damage to Locus Coeruleus Neurons Converts Sporadic Seizures into Self-Sustaining Limbic Status Epilepticus. The European Journal of Neuroscience, 17, 2593-2601.
https://doi.org/10.1046/j.1460-9568.2003.02692.x |
| [27] | Zhang, H., Zhao, H., Zeng, C., et al. (2018) Optogenetic Activation of 5-HT Neurons in the Dorsal Raphe Suppresses Seizure-Induced Respiratory Arrest and Produces Anti-convulsant Effect in the DBA/1 Mouse SUDEP Model. Neurobiology of Disease, 110, 47-58. https://doi.org/10.1016/j.nbd.2017.11.003 |
| [28] | Parsons, L., Kerr, T. and Tecott, L. (2001) 5-HT(1A) Receptor Mutant Mice Exhibit Enhanced Tonic, Stress-Induced and Fluoxetine-Induced Serotonergic Neurotransmission. Journal of Neurochemistry, 77, 607-617.
https://doi.org/10.1046/j.1471-4159.2001.00254.x |
| [29] | Barker-Haliski, M. and White, H. (2015) Glutamatergic Mechanisms Associated with Seizures and Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5, a022863. https://doi.org/10.1101/cshperspect.a022863 |
| [30] | Yüksel, C. and ？ngür, D. (2010) Magnetic Resonance Spec-troscopy Studies of Glutamate-Related Abnormalities in Mood Disorders. Biological Psychiatry, 68, 785-794. https://doi.org/10.1016/j.biopsych.2010.06.016 |
| [31] | Luscher, B., Shen, Q. and Sahir, N. (2011) The GABAergic Deficit Hypothesis of Major Depressive Disorder. Molecular Psychiatry, 16, 383-406. https://doi.org/10.1038/mp.2010.120 |
| [32] | Culebras, A., Miller, M., Bertram, L., et al. (1987) Differential Response of Growth Hormone, Cortisol, and Prolactin to Seizures and to Stress. Epilepsia, 28, 564-570. https://doi.org/10.1111/j.1528-1157.1987.tb03689.x |
| [33] | Abbott, R., Browning, M. and Davidson, D. (1980) Se-rum Prolactin and Cortisol Concentrations after Grand Mal Seizures. Journal of Neurology, Neurosurgery, and Psychia-try, 43, 163-167. https://doi.org/10.1136/jnnp.43.2.163 |
| [34] | Dorovini-Zis, K. and Zis, A. (1987) Increased Adrenal Weight in Victims of Violent Suicide. The American Journal of Psychiatry, 144, 1214-1215. https://doi.org/10.1176/ajp.144.9.1214 |
| [35] | Holsboer, F. (2000) The Corticosteroid Receptor Hypothesis of De-pression. Neuropsychopharmacology, 23, 477-501.
https://doi.org/10.1016/S0893-133X(00)00159-7 |
| [36] | Asadi-Pooya, A., Kanemoto, K., Kwon, O., et al. (2018) Depression in People with Epilepsy: How Much Do Asian Colleagues Acknowledge It? Seizure, 57, 45-49. https://doi.org/10.1016/j.seizure.2018.03.012 |
| [37] | Wulsin, A., Franco-Villanueva, A., Romancheck, C., et al. (2018) Functional Disruption of Stress Modulatory Circuits in a Model of Temporal Lobe Epilepsy. PLOS ONE, 13, e0197955. https://doi.org/10.1371/journal.pone.0197955 |
| [38] | Hooper, A., Paracha, R. and Maguire, J. (2018) Seizure-Induced Activation of the HPA Axis Increases Seizure Frequency and Comorbid Depression-Like Behaviors. Epilepsy & Behav-ior: E&B, 78, 124-133.
https://doi.org/10.1016/j.yebeh.2017.10.025 |
| [39] | 张伊佳, 秦炯. 免疫炎症因素在癫痫中的作用机制[J]. 中国免疫学杂志, 2019, 35(8): 1024-1026. |
| [40] | Weidner, L., Kannan, P., Mitsios, N., et al. (2018) The Expression of In-flammatory Markers and Their Potential Influence on Efflux Transporters in Drug-Resistant Mesial Temporal Lobe Epi-lepsy Tissue. Epilepsia, 59, 1507-1517.
https://doi.org/10.1111/epi.14505 |
| [41] | Vieira, é., De Oliveira, G., Lessa, J., et al. (2016) Peripheral Leukocyte Pro-file in People with Temporal Lobe Epilepsy Reflects the Associated Proinflammatory State. Brain, Behavior, and Immun-ity, 53, 123-130.
https://doi.org/10.1016/j.bbi.2015.11.016 |
| [42] | Ethemoglu, O., Cal？k, M., Koyuncu, I., et al. (2021) Interleukin-33 and Oxidative Stress in Epilepsy Patients. Epilepsy Research, 176, Article ID: 106738. https://doi.org/10.1016/j.eplepsyres.2021.106738 |
| [43] | Beurel, E., Harrington, L. and Jope, R. (2013) Inflammatory T Helper 17 Cells Promote Depression-Like Behavior in Mice. Biological Psychiatry, 73, 622-630. https://doi.org/10.1016/j.biopsych.2012.09.021 |
| [44] | Beurel, E. and Lowell, J. (2018) Th17 Cells in Depression. Brain, Behavior, and Immunity, 69, 28-34.
https://doi.org/10.1016/j.bbi.2017.08.001 |
| [45] | Choi, I., Cho, M. and Cho, K. (2022) Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety. Frontiers in Molecular Neuroscience, 15, Article ID: 917598.
https://doi.org/10.3389/fnmol.2022.917598 |
| [46] | Colmers, P. and Maguire, J. (2020) Network Dysfunction in Comorbid Psychiatric Illnesses and Epilepsy. Epilepsy Currents, 20, 205-210. https://doi.org/10.1177/1535759720934787 |
| [47] | Gilliam, F., Maton, B., Martin, R., et al. (2007) Hippocampal 1H-MRSI Correlates with Severity of Depression Symptoms in Temporal Lobe Epilepsy. Neurology, 68, 364-368. https://doi.org/10.1212/01.wnl.0000252813.86812.81 |
| [48] | Fang, P., An, J., Zeng, L., et al. (2017) Mapping the Convergent Temporal Epileptic Network in Left and Right Temporal Lobe Epilepsy. Neuroscience Letters, 639, 179-184. https://doi.org/10.1016/j.neulet.2016.12.029 |
| [49] | Briellmann, R., Hopwood, M. and Jackson, G. (2007) Major De-pression in Temporal Lobe Epilepsy with Hippocampal Sclerosis: Clinical and Imaging Correlates. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 1226-1230.
https://doi.org/10.1136/jnnp.2006.104521 |
| [50] | Lv, R., Sun, Z., Cui, T., et al. (2014) Temporal Lobe Epilepsy with Amygdala Enlargement: A Subtype of Temporal Lobe Epilepsy. BMC Neurology, 14, Article No. 194. https://doi.org/10.1186/s12883-014-0194-z |
| [51] | Elst, L., Groffmann, M., Ebert, D., et al. (2009) Amygdala Vol-ume Loss in Patients with Dysphoric Disorder of Epilepsy. Epilepsy & Behavior: E&B, 16, 105-112. https://doi.org/10.1016/j.yebeh.2009.06.009 |
| [52] | Hsu, D. (2007) The Dentate Gyrus as a Filter or Gate: A Look Back and a Look Ahead. Progress in Brain Research, 163, 601-613. https://doi.org/10.1016/S0079-6123(07)63032-5 |
| [53] | Bengzon, J., Kokaia, Z., Elmér, E., et al. (1997) Apoptosis and Proliferation of Dentate Gyrus Neurons after Single and Intermittent Limbic Seizures. Proceedings of the National Academy of Sciences of the United States of America, 94, 10432-10437. https://doi.org/10.1073/pnas.94.19.10432 |
| [54] | Hattiangady, B., Rao, M. and Shetty, A. (2004) Chronic Temporal Lobe Epilepsy Is Associated with Severely Declined Dentate Neurogenesis in the Adult Hippocampus. Neurobiology of Disease, 17, 473-490.
https://doi.org/10.1016/j.nbd.2004.08.008 |
| [55] | Mirescu, C., Peters, J., Noiman, L., et al. (2006) Sleep Deprivation Inhibits adult Neurogenesis in the Hippocampus by Elevating Glucocorticoids. Proceedings of the National Academy of Sciences of the United States of America, 103, 19170-19175. https://doi.org/10.1073/pnas.0608644103 |
| [56] | Madsen, T., Treschow, A., Bengzon, J., et al. (2000) Increased Neurogenesis in a Model of Electroconvulsive Therapy. Biological Psychiatry, 47, 1043-1049. https://doi.org/10.1016/S0006-3223(00)00228-6 |
| [57] | Micheli, L., Ceccarelli, M., D’andrea, G., et al. (2018) De-pression and Adult Neurogenesis: Positive Effects of the Antidepressant Fluoxetine and of Physical Exercise. Brain Re-search Bulletin, 143, 181-193.
https://doi.org/10.1016/j.brainresbull.2018.09.002 |
| [58] | Jain, S., Lafrancois, J., Gerencer, K., et al. (2023) Increas-ing Adult Neurogenesis Protects Mice from Epilepsy. eLife, 12, RP90893. https://doi.org/10.7554/eLife.90893 |
| [59] | 陈艳艳, 桑红, 林卫红. 成人癫痫与抑郁[J]. 癫痫杂志, 2020, 6(1): 26-33. |
| [60] | 李志艳, 姚丽芬. 癫痫共患焦虑的临床研究[J]. 脑与神经疾病杂志, 2018, 26(1): 57-61. |
| [61] | Scheffer, I., Berkovic, S., Capovilla, G., et al. (2017) ILAE Classification of the Epilepsies: Position Paper of the ILAE Commission for Classification and Terminology. Epi-lepsia, 58, 512-521. https://doi.org/10.1111/epi.13709 |
