Adverse Pregnancy Outcomes Following Cryotherapy, Thermal Ablation and Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia Treatment: A Pilot Study among Zambian Women
Background:Cervical Intraepithelial neoplasia treatments have become essential
interventions to manage cervical lesions. Majority of the recipients of these treatments are
women within the reproductive age group, who according to literature maybe at risk of adverse
pregnancy outcomes. This pilot study is part
of a study investigating adverse pregnancy outcomes
among women who received Cryotherapy, Thermal ablation and Loop Electrosurgical
Excision Procedure compared to the untreated women in Zambia. Materials and Methods: This descriptive study analyzed records of 886 (n=443
treated and n=443 untreated)women aged 15 - 49 years. The women were
either screened with Visual Inspection with Acetic Acid or treated for Cervical
Intraepithelial neoplasia at the Adult Infectious Disease Centre between
January 2010 and December 2020. Women meeting the criteria were identified
using the Visual Inspection with Acetic Acid screening records and telephone
interviews to obtain the adverse pregnancy outcome experienced. Data were analysed using STATA
version 16 to determine the prevalence and obtain frequency distribution of
outcomes of interest. Univariate and multivariable binary logistic regression
estimated odds of adverse pregnancy outcomes across the three treatments. Results: The respondents were
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