Introduction: Infections are significant causes of mortality in
sickle cell children in resource-limited countries. This study
aimed to determine the clinical profile and bacterial ecology of infections in
children with sickle-cell disease in two referral hospitals in Niamey. Patients
and methods: A retrospective descriptive study was conducted from January
2018 to July 2020 in two referral hospitals in Niamey. All children aged one
(1) to 15 years with sickle cell disease
admitted for suspected infection, including at least one bacterial culture,
were studied. Bacteriological analysis was performed using the appropriate
culture media, using BactAlert (Reference 4700003 BTA3D60 BioMérieux). Results: Over 36-months, 350 children with a mean age of 10.9 months were admitted.
The sex ratio was 1.2. The SS electrophoretic profile was the most common
(93.4%). Immunization status was up to date in 66% of patients. Fever was the
common reason for consultation (55.1%). Infection was confirmed in 62 patients
(17.7%). The primary diagnoses were bacterial gastroenteritis (24.2%) and
urinary tract infection (19.4%). Blood cultures were isolated from Salmonella typhi (13.0%) and Escherichia coli (8.7%). Klebsiella spp (7.1%) and Escherichia coli (5.0%)were
detected in
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