Introduction: Neonatal jaundice (NNJ) is a common disorder in neonates that can
impact negatively on the brain and cause death. The peculiarities in aetiology
and solutions for different settings are a knowledge gap. This informed the desire to determine local aetiology
and solutions for neonatal jaundice in a missionary hospital in Abeokuta,
Southwestern Nigeria. Methods: Consecutive consenting babies diagnosed
with significant neonatal jaundice were studied between July 2016 and June
2019. Institutional ethical consent was obtained. A proforma was used to obtain
socio-demographic data and other relevant information such as age, sex,birthweight,
gestational age and history regarding the jaundice. All the information obtained
was inputted into a computer and analysed with SPSS version 16. Results:
A total of 179 babies with neonatal jaundice comprising of 120 (67.0%) boys and
59 (33.0%) girls with ages ranging between 1 and 12 days (mean 2.7 ± 2.9) were
studied. Prematurity, ABO incompatibility, neonatal sepsis and
glucose-6-phosphate enzyme deficiency accounted for over 80% of the causes of
significant NNJ. Sixty (33.5%) of the 179 babies studied developed acute
bilirubin encephalopathy and 11(6.1%)
mortalities were recorded. Higher proportions of babies that were out-bornwith spontaneous vaginal
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