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炎症与氧化应激在急性肺损伤中的作用研究进展
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Abstract:
急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)一种以肺实质弥漫性炎症和顽固性低氧血症为特征的临床危重症疾病。尽管近几年国内外对ALI/ARDS进行深入研究，但由于其病因复杂、发病机制尚不明确，临床上亦无明确的可治愈药物，使得ALI/ARDS患者的总体生存质量和生存率均较低。近年来，大量文献报道炎症反应以及氧化应激与ALI/ARDS的发展密切相关，本文就炎症反应和氧化应激反应在ALI/ARDS发生发展中的作用进行综述，以期为ALI/ARDS的治疗和药物研发提供相关理论依据。
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a clinical critical disease characterized by diffuse inflammation of lung parenchyma and intractable hypoxemia. Although ALI/ARDS has been studied deeply in recent years, the overall quality of life and survival rate of ALI/ARDS patients are low due to its complex etiology, unclear pathogenesis and no clear clinical cure. In recent years, it has been reported that inflammation and oxidative stress are closely related to the development of ALI/ARDS. This paper reviews the role of inflammation and oxidative stress in the occurrence and development of ALI/ARDS, in order to provide relevant theoretical basis for developing drugs and treatment of ALI/ARDS.
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