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基于肠道微生态治疗糖尿病肾病的研究进展
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Abstract:
肠道微生态在糖尿病肾病(DKD)进展中的作用越来越受到关注。一方面，肾功能下降会增加循环尿毒症毒素，影响肠道菌群的组成和功能。另一方面，肠道菌群失调会破坏上皮屏障，导致内毒素暴露增加，诱发微生态炎症级联反应，包括抑制黏附分子、趋化因子、细胞因子、免疫细胞和细胞内信号通路的表达，从而加剧肾脏损伤。本综述主要总结了肠–肾轴在糖尿病肾病进展中的证据，以期为糖尿病肾病的临床治疗提供新的思路。
The role of intestinal microecology in the progression of diabetic nephropathy (DKD) has attracted more and more attention. On the one hand, decreased renal function will increase circulating uremic toxins and affect the composition and function of intestinal flora. On the other hand, the imbalance of intestinal flora can destroy the epithelial barrier, lead to increased endotoxin exposure, and induce microecological inflammatory cascade reactions, including inhibition of the expression of adhesion molecules, chemokines, cytokines, immune cells and intracellular signal pathways, thus aggravating renal damage. This review mainly summarizes the evidence of enterorenal axis in the progression of diabetic nephropathy, in order to provide new ideas for the clinical treatment of diabetic nephropathy.
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