Introduction:
Measles remains a worrying health problem in sub-Saharan African countries.
There have been measles outbreaks in Cameroon with the most recent occurring
between October 2022 and September 2023. The Centre region of Cameroon was the
most affected in the country and being at the frontline of the fight against
this illness, we conducted this study in order to determine the epidemiological
and clinical characteristics as well as the outcome of children who contracted
the measles and were hospitalized at the Yaoundé Gynaeco-Obstetric and Pediatric
Hospital. Methodology: We conducted a cross-sectional descriptive and
prospective study for one year from October 2022 to November 2023 corresponding
to the duration of the outbreak. We included all children admitted in the
pediatric unit for measles and its complications during this period. Results: In
total, 60 children were enrolled. Their caregivers were mostly their mothers
who had a mean age of 34.71 ± 9.55 years living in significant precarious
conditions for the majority. The median age of children was 16 months (09 - 30
months).Twenty six percent of children (16) were less than 9 months. Girls were
predominant (55%). Most children were not up to date with their routine EPI
vaccination (80%) and most did not receive the measles and Rubella vaccine
(76.67%). Clinical manifestations, included fever, conjunctivitis, and cough.
Skin rash and catarrh (98.33% and 86.67% respectively) are the case definition
signs of measles. The outcome was unfavorable for 4 children. One had a
neurological disorder: coma and three presented with pneumonia and severe
respiratory distress (6.67%). Conclusion: Measles is
References
[1]
Antona, D., Dina, J., Soing-Altrach, S., Aït-Belghiti, F., Georges, S., Maine, C. and Lévy-Bruhl, D. (2019) épidémiologie de la rougeole en Franceen 2011-2018. Bulletin épidémiologique Hebdomadaire, 13, 218-227.
[2]
Boushab, B.M., Savadogo, M., Sow, M.S. and Dao, S. (2015) Epidemiological, Clinical, and Prognostic Study of the Measles in the Aioun Regional Hospital in Mauritania. Médecine et Santé Tropicales, 25, 180-183.
https://doi.org/10.1684/mst.2015.0447
[3]
Cherry, J.D. and Zahn, M. (2018) Clinical Characteristics of Measles in Previously Vaccinated and Unvaccinated Patients in California. Clinical Infectious Diseases, 67, 1315-1319. https://doi.org/10.1093/cid/ciy286
[4]
Domai, F.M., Agrupis, K.A., Han, S.M., Sayo, A.R., Ramirez, J.S., Nepomuceno, R., Suzuki, S., Villanueva, A.M.G., Salva, E.P., Villarama, J.B., Ariyoshi, K., Mulholland, K., Palla, L., Takahashi, K., Smith, C. and Miranda, E. (2022) Measles Outbreak in the Philippines: Epidemiological and Clinical Characteristics of Hospitalized Children, 2016-2019. The Lancet, 19, Article ID: 100334.
https://doi.org/10.1016/j.lanwpc.2021.100334
[5]
Eposi, H.C. and Benjamin, K.M. (n.d.) Measles Outbreak Investigation in a Highly Vaccinated Community in the Centre Region of Cameroon. Journal of Public Health in Africa, 12, 1.
[6]
Gianniki, M., Siahanidou, T., Botsa, E. and Michos, A. (2021) Measles Epidemic in Pediatric Population in Greece during 2017–2018: Epidemiological, Clinical Characteristics and Outcomes. PLOS ONE, 16, e0245512.
https://doi.org/10.1371/journal.pone.0245512
[7]
Hassan, M.Y., Mohamud, R.Y.H., Kassim, M.M., Hussein, A.I., Adam, M.K., Akbulut, U.E., Olum, R., Okot, J., Bongomin, F. and Ahmed, M.A.M. (2023) Clinical Characteristics and Outcomes of Patients Hospitalized with Measles during an Outbreak in Somalia. IJID Regions, 8, 31-35.
https://doi.org/10.1016/j.ijregi.2023.05.003
[8]
Laksono, B., De Vries, R., McQuaid, S., Duprex, W. and De Swart, R. (2016) Measles Virus Host Invasion and Pathogenesis. Viruses, 8, 210.
https://doi.org/10.3390/v8080210
[9]
Martins, C.L., Garly, M.-L., Bale, C., Rodrigues, A., Ravn, H., Whittle, H.C., Lisse, I. M. and Aaby, P. (2008) Protective Efficacy of Standard Edmonston-Zagreb Measles Vaccination in Infants Aged 4.5 Months: Interim Analysis of a Randomised Clinical Trial. BMJ, 337, a661. https://doi.org/10.1136/bmj.a661
[10]
WHO (2023) Measles. https://www.who.int/news-room/fact-sheets/detail/measles
[11]
Muthiah, N., Galagoda, G., Handunnetti, S., Peiris, S. and Pathirana, S. (2021) Dynamics of Maternally Transferred Antibodies against Measles, Mumps, and Rubella in Infants in Sri Lanka. International Journal of Infectious Diseases, 107, 129-134.
https://doi.org/10.1016/j.ijid.2021.04.002
[12]
Nomhwange, T., Mohammed, A., Jean Baptiste, A.E., Musa, A., Yusuf, A., Yusuf, M., Wagai, J., Shettima, A., Mele, S., Banda, R., Braka, F., Luce, R. and Masresha, B. (2022) Measles Outbreak Response Immunization during the COVID-19 Pandemic: Lessons from Borno State, Nigeria. Pan African Medical Journal, 41, Article 104.
https://doi.org/10.11604/pamj.2022.41.104.28162
[13]
Olugbade, O.T., Adeyemi, A.S., Adeoti, H.A., Ilesanmi, O.S., Gidado, S.O., Waziri, N.E. and Aworh, M. (2019) Measles Outbreaks and Supplemental Immunization Activities (SIAs): The Gwagwalada Experience, Abuja 2015. Pan African Medical Journal, 32, Article No. 10. https://doi.org/10.11604/pamj.supp.2019.32.1.13368
[14]
Sindhu, T., Geeta, M., Krishnakumar, P., Sabitha, S. and Ajina, K. (2019) Clinical Profile of Measles in Children with Special Reference to Infants. Tropical Doctor, 49, 20-23. https://doi.org/10.1177/0049475518804695
[15]
Sodjinou, V.D., Mengouo, M.N., Douba, A., Tanifum, P., Yapi, M.D., Kuzanwa, K. R., Otomba, J.S. and Masresha, B. (2022) Epidemiological Characteristics of a Protracted and Widespread Measles Outbreak in the Democratic Republic of Congo, 2018-2020. The Pan African Medical Journal, 42, 282.
[16]
WHO (2022) UNICEF and WHO Warn of Perfect Storm of Conditions for Measles Outbreaks, Affecting Children.
https://www.who.int/news/item/27-04-2022-unicef-and-who-warn-of--perfect-storm--of-conditions-for-measles-outbreaks--affecting-children
[17]
Wang, X.-Y., Zhang, X.-J., Xia, X., Chang, S.-Z. and Wu, A.-Z. (2023) Epidemiological and Clinical Characteristics of Measles in Jinan, Shandong Province, China, from 1991 to 2022. International Journal of General Medicine, 16, 2305-2312.
https://doi.org/10.2147/IJGM.S407121