全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

蒙药玉簪花化学成分和药理作用机制研究进展
Research Progress on Chemical Constituents and Pharmacological Mechanism of Mongolian Medicine Hosta plantaginea Flowers

DOI: 10.12677/OJNS.2024.121022, PP. 185-194

Keywords: 玉簪花,化学成分,药理作用
Hosta plantaginea Flowers
, Chemical Constituents, Pharmacological Activities

Full-Text   Cite this paper   Add to My Lib

Abstract:

蒙药玉簪花为百合科Liliaceae玉簪属Hosta玉簪Hosta plantaginea的干燥花,作为蒙医药常用药材,广泛用于治疗急慢性咽炎等疾病。现代植物化学和药理学研究表明,玉簪花化学成分主要包括甾体类、黄酮类、生物碱类等,具有抗炎、抗菌、抗肿瘤、抗氧化、保肝、镇痛等药理作用。本文综述了近年来玉簪花化学成分和药理作用最新研究进展,以期为玉簪花在药品和食品等方面资源开发和利用提供理论基础。
The Mongolian medicine Hosta plantaginea flowers is a dried flower of the genus Hosta in the Liliaceae family. As a common medicinal material in Mongolian medicine, it is widely used to treat diseases such as acute and chronic pharyngitis. Modern phytochemical and pharmacologi-cal studies have shown that the chemical constituents of H. plantaginea flowers mainly include steroids, flavonoids, alkaloids and so on, which have pharmacological activities such as anti-inflammatory, anti-bacterial, anti-tumor, anti-oxidation, liver protection, and analgesia. This paper reviewed the latest research progress on the chemical constituents and pharmacological activities of H. plantaginea flowers in recent years in order to provide theoretical basis for the resource development and utilization of H. plantaginea flowers in medicine and food.

References

[1]  陈叶. 玉簪属植物耐阴性研究概况及展望[J]. 江苏农业科学, 2021, 49(15): 47-52.
[2]  中国科学院中国植物志编辑委员会. 中国植物志(第14卷) [M]. 北京: 科学出版社, 1980.
[3]  关梦茜, 董然. 玉簪属植物研究进展及园林应用[J]. 北方园艺, 2013(19): 182-185.
[4]  Wang, Y.H., Zhang, Z.K., Yang, F.M., et al. (2007) Benzylphene-thylamine Alkaloids from Hosta plantaginea with Inhibitory Activity against Tobacco Mosaic Virus and Acetyl-cholinesterase. Journal of Natural Products, 70, 1458-1461.
https://doi.org/10.1021/np0702077
[5]  Wang, M.Y., Peng, Y., Peng, C.S., Qu, J.Y. and Li, X.B. (2018) The Bioassay-Guided Isolation of Antifungal Saponins from Hosta plantaginea Leaves. Journal of Asian Natural Products Research, 20, 501-509.
https://doi.org/10.1080/10286020.2017.1329304
[6]  Mimaki, Y., Kameyama, A., Kuroda, M., et al. (1997) Steroidal Glycosides from the Underground Parts of Hosta plantaginea var. japonica and Their Cytostatic Activity on Leukaemia HL-60 Cells. Phytochemistry, 44, 305-310.
https://doi.org/10.1016/S0031-9422(96)00548-1
[7]  麻剑南, 马超美, 田志杰, 等. UPLC-MS法同时测定玉簪花中3种成分[J]. 中成药, 2017, 39(3): 639-641.
[8]  国家中医药管理局中华本草编委会. 中华本草(蒙药卷) [M]. 上海: 上海科学技术出版社, 2004.
[9]  冯闪闪, 张盼盼. 蒙药玉簪清咽十五味丸治疗急慢性咽喉炎的效果观察及护理体会[J]. 中国民族医药杂志, 2020, 26(2): 79-80.
[10]  乌兰图雅, 包勒朝鲁. 清咽六味散治疗急性咽炎的研究进展[J]. 世界临床药物, 2022, 43(8): 1063-1066.
[11]  李文媛. 蒙药玉簪花的化学成分及生物活性初步研究[D]: [硕士学位论文]. 武汉: 华中科技大学, 2011.
[12]  张金花, 解红霞, 薛培凤, 等. 蒙药玉簪花中的甾体化合物[J]. 中国药学杂志, 2010, 45(5): 335-337.
[13]  张金花. 蒙药玉簪花化学成分研究[D]: [硕士学位论文]. 呼和浩特: 内蒙古医学院, 2012.
[14]  刘接卿, 王翠芳, 邱明华, 等. 玉簪花的抗肿瘤活性甾体皂苷成分研究[J]. 中草药, 2010, 41(4): 520-526.
[15]  王丽. 蒙药玉簪花的植物化学研究[D]: [硕士学位论文]. 呼和浩特: 内蒙古医科大学, 2016.
[16]  Li, X.J., Wang, L., Xue, P.F., et al. (2015) New Steroidal Glycosides from Hosta plantaginea (Lam.) Aschers. Journal of Asian Natural Products Research, 17, 224-231.
https://doi.org/10.1080/10286020.2014.998652
[17]  解红霞, 张金花, 张宏桂, 等. 蒙药玉簪花的化学成分研究[J]. 中国药学杂志, 2009, 44(10): 733-735.
[18]  Zhang, Y., Liu, J., Wang, M., Sun, C.J. and Li, X.B. (2020) Five New Compounds from Hosta plantaginea Flowers and Their Anti-inflammatory Activities. Bioorganic Chemistry, 95, Article ID: 103494.
https://doi.org/10.1016/j.bioorg.2019.103494
[19]  He, J.W., Yang, L., Mu, Z.Q., et al. (2018) An-ti-Inflammatory and Antioxidant Activities of Flavonoids from the Flowers of Hosta plantaginea. RSC Advances, 8, 18175-18179.
https://doi.org/10.1039/C8RA00443A
[20]  Hu, Y., Li, J., Chang, A.K., et al. (2022) Potential Active Constituents Responsible for Treating Acute Pharyngitis in the Flowers of Hosta plantaginea (Lam.) Aschers and Their Pharmacokinetics. Food & Function, 13, 3308-3317.
https://doi.org/10.1039/D1FO03712A
[21]  王丽, 魏慧, 王静, 等. 蒙药玉簪花的化学成分研究(Ⅱ) [J]. 中草药, 2019, 50(2): 330-335.
[22]  周庆光, 杨丽, 何军伟, 等. 玉簪花中1个新黄酮苷类化合物及其抗氧化活性研究[J]. 中国中药杂志, 2019, 44(15): 3312-3315.
[23]  He, J., Huang, X., Wang, Y., et al. (2019) A New Flavonol Glycoside from the Flowers of Hosta plantaginea with Cyclooxygenases-1/2 Inhibitory and Antioxidant Activities. Natural Product Research, 33, 1599-1604.
https://doi.org/10.1080/14786419.2018.1428591
[24]  Yang, L., Zhu, Y., He, Z., et al. (2021) Plantanone D, a New Rare Methyl-Flavonoid from the Flowers of Hosta plantaginea with Anti-Inflammatory and Antioxidant Ac-tivities. Natural Product Research, 35, 4331-4337.
https://doi.org/10.1080/14786419.2020.1713121
[25]  周庆光. 蒙药玉簪花抗Ⅲ型前列腺炎的化学成分、抗氧化活性及总黄酮提取工艺研究[D]: [硕士学位论文]. 南昌: 江西中医药大学, 2020.
[26]  Yang, L., Jiang, S.T., Zhou, Q.G., et al. (2017) Chemical Constituents from the Flower of Hosta plantaginea with Cyclooxygenases In-hibition and Antioxidant Activities and Their Chemotaxonomic Significance. Molecules, 22, Article 1825.
https://doi.org/10.3390/molecules22111825
[27]  Yang, L. and He, J. (2022) Anti-Inflammatory Effects of Flavonoids and Phenylethanoid Glycosides from Hosta plantaginea Flowers in LPS-Stimulated RAW 264.7 Mac-rophages through Inhibition of the NF-κB Signaling Pathway. BMC Complementary Medicine and Therapies, 22, Article No. 55.
https://doi.org/10.1186/s12906-022-03540-1
[28]  玉华, 王青虎, 韩晶晶, 等. 玉簪花化学成分的研究[J]. 中成药, 2017, 39(1): 107-111.
[29]  Yang, L., Lin, Y.M., He, Z.W., et al. (2020) Hostaflavanol A, a New Anti-Inflammatory and Antioxidant Activities Flavanol from the Flowers of Hosta plantaginea. Medicinal Chemistry Research, 29, 426-430.
https://doi.org/10.1007/s00044-019-02491-6
[30]  He, J.W., Guo, P., Yang, L. and He, J.W. (2023) An-ti-Inflammatory Constituents Isolated from the Flowers of Hosta plantaginea via Suppression of the NF-κB Signaling Pathway in LPS-stimulated RAW 264.7 Macrophages. RSC Advances, 13, 7179-7184.
https://doi.org/10.1039/D2RA07623C
[31]  Wei, R., Ma, Q., Zhong, G., et al. (2020) Isolation and Character-ization of Flavonoid Derivatives with Anti-Prostate Cancer and Hepatoprotective Activities from the Flowers of Hosta plantaginea (Lam.) Aschers. Journal of Ethnopharmacology, 253, Article ID: 112685.
https://doi.org/10.1016/j.jep.2020.112685
[32]  Wei, R. and Ma, Q. (2020) Indole Alkaloids from Hosta plantaginea and Inhibition of Steroid 5α-Reductase Activities in Vitro. Chemistry of Natural Compounds, 56, 888-891.
https://doi.org/10.1007/s10600-020-03176-y
[33]  Wang, Q., Han, J. and Bao, B. (2017) Antibacte-rial Effects of Two Monoterpene Glycosides from Hosta plantaginea (Lam.) Aschers. Journal of Food Biochemistry, 41, e12320.
https://doi.org/10.1111/jfbc.12320
[34]  Bao, X.H.,Wang, Q.H., Bao, B.Y.Q.E., Han, J.J. and Ao, W.L.J. (2017) Antibacterial and Antioxidant Activities of Megastigmane Glycosides from Hosta plantaginea. Chemistry of Natural Compounds, 53, 614-617.
https://doi.org/10.1007/s10600-017-2071-7
[35]  解红霞, 薛培凤. 玉簪花中一个新的神经鞘苷[J]. 中国药业, 2014, 23(5): 12-14.
[36]  李春燕, 薛培凤, 刘美娜, 等. 蒙药玉簪花抗炎作用研究[J]. 时珍国医国药, 2015, 26(7): 1559-1560.
[37]  辛颖, 达拉胡. 蒙药玉簪花不同萃取部位抗炎活性研究[J]. 亚太传统医药, 2015, 11(23): 5-7.
[38]  Fang, Y., Yang, L. and He, J. (2021) Plantanone C Attenuates LPS-Stimulated Inflammation by Inhibiting NF-κB/iNOS/ COX-2/MAPKs/Akt Pathways in RAW 264.7 Macrophages. Biomedicine & Pharmacotherapy, 143, Article ID: 112104.
https://doi.org/10.1016/j.biopha.2021.112104
[39]  Fang, Y., Wang, H., Xia, X., Yang, L. and He, J.W. (2022) Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside Isolated from the Flowers of Hosta plantaginea Exerts Anti-Inflammatory Activity via Suppression of NF-κB, MAPKs and Akt Pathways in RAW 264.7 Cells. Biomedicine & Pharmacotherapy, 153, Article ID: 113295.
https://doi.org/10.1016/j.biopha.2022.113295
[40]  Yang, L., Cao, L., Li, C., et al. (2022) Hostaflavone A from Hosta plantaginea (Lam.) Asch. Blocked NF-κB/iNOS/COX- 2/MAPKs/Akt Signaling Pathways in LPS-induced RAW 264.7 Macrophages. Journal of Ethnopharmacology, 282, Article ID: 114605.
https://doi.org/10.1016/j.jep.2021.114605
[41]  武毛毛, 李春燕, 李凤英, 等. 蒙药玉簪花对急性咽炎模型大鼠的治疗作用及对细胞因子的影响[J]. 内蒙古大学学报(自然科学版), 2018, 49(5): 507-514.
[42]  王秀梅, 梁新丽, 管咏梅, 等. 蒙药玉簪花提取物指标成分含量测定及其抗慢性前列腺炎的研究[J]. 中华中医药杂志, 2018, 33(5): 2070-2074.
[43]  王秀梅, 包雪梅, 海红霞, 等. 玉簪花提取物对RAW264.7细胞炎症及哮喘小鼠气道炎症的影响[J]. 华西药学杂志, 2023, 38(5): 488-492.
[44]  Wang, H., Li, X., Xia, B., et al. (2023) Amelioration of Chronic Prostatitis by Fractions of Mongolian Medicine Hosta plantaginea Flowers via Inhibition of NF-κB, MAPKs, JAK-STAT, and PI3K-Akt Signaling Pathways in Rats. Journal of Ethnopharmacology, 307, Article ID: 116245.
https://doi.org/10.1016/j.jep.2023.116245
[45]  Yang, L., Zhang, F., He, W., et al. (2024) Extraction Optimi-zation and Constituent Analysis of Total Flavonoid from Hosta plantaginea (Lam.) Aschers Flowers and Its Ame-liorative Effect on Chronic Prostatitis via Inhibition of Multiple Inflammatory Pathways in Rats. Journal of Eth-nopharmacology, 318, Article ID: 116922.
https://doi.org/10.1016/j.jep.2023.116922
[46]  Wang, J., Cao, L., Wang, H., et al. (2024) Therapeutic Effect of Hosta plantaginea (Lam.) Aschers Flowers on Acute Pharyngitis through Inhibition of Multi-Inflammatory Pathways in Rats. Journal of Ethnopharmacology, 318, Article ID: 116966.
https://doi.org/10.1016/j.jep.2023.116966
[47]  王佳水. 玉簪花抗咽炎的药效学及作用机制研究[D]: [硕士学位论文]. 南昌: 江西中医药大学, 2023.
[48]  辛颖, 白玉花. 蒙药玉簪花乙醇提取物体外和体内的抑菌活性研究[J]. 中成药, 2015, 37(3): 653-656.
[49]  叶晓川, 李文媛, 颜彦, 等. 玉簪花体外抑菌实验研究[C]//中国药学会. 第九届全国中药和天然药物学术研讨会大会报告及论文集. 2007: 573-576.
[50]  武毛毛, 李晓娟, 薛培凤, 等. 蒙药玉簪花中支托皂苷元及其三个皂苷的体外细胞毒活性研究[J]. 现代中药研究与实践, 2018, 32(2): 16-18.
[51]  解红霞, 薛培凤, 周静, 等. 蒙药玉簪花镇痛作用的实验研究[J]. 内蒙古医学院学报, 2010, 32(1): 36-38.
[52]  王娜娜, 薛培凤, 耿婕, 等. 蒙药玉簪花总多糖提取工艺优选与含量测定[J]. 中国药业, 2014, 23(15): 47-49.
[53]  解红霞, 薛培凤, 张宏桂, 等. 可见分光光度法测定玉簪花中总皂苷的含量[J]. 北京中医药大学学报, 2009, 32(9): 624-625+645.
[54]  王静, 薛培凤, 赵子龙, 等. 紫外分光光度法测定蒙药玉簪花中总黄酮的含量[J]. 内蒙古医科大学学报, 2013, 35(2): 93-95.
[55]  奥?乌力吉, 白明刚, 王胡格吉乐图, 等. 玉簪花的色谱鉴别和含量测定研究[J]. 中国药品标准, 2012, 13(5): 347-350.
[56]  何健, 高英, 李卫民. HPLC法测定蒙药玉簪花中山奈酚葡萄糖苷的含量[J]. 中药新药与临床药理, 2010, 21(2): 192-194.
[57]  李晓娟, 薛培凤, 鞠爱华, 等. 蒙药玉簪花中山奈酚的HPLC含量测定与薄层色谱鉴别[J]. 内蒙古医学院学报, 2011, 33(4): 307-310.
[58]  何健. 蒙药玉簪花质量标准及化学成分研究[D]: [硕士学位论文]. 广州: 广州中医药大学, 2011.
[59]  李慧芳, 王敏杰, 朱贺年. 蒙药材玉簪花指纹图谱研究[J]. 中国医药导报, 2017, 14(13): 34-37.

Full-Text

comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133