Background: Neonatal sepsis is known to result in 26% of mortalities
in children below the age of five worldwide, countries in Sub-Saharan African recording
the highest deaths. Although the deaths of neonates have reduced world over up to
3.6 million counts, Chilenje General Hospital continues to register significant
numbers of neonatal sepsis. This study aimed at investigating the factors associated
with neonatal sepsis at Chilenje General Hospital in Lusaka, Zambia. Methods:An institution based cross-sectional
study design was conducted at Chilenje General Hospital. Data were collected by
the use of a researcher designed questionnaire and analysed using SPSS version 25.
Frequencies were used for descriptive analysis while bivariate analysis was used to establish association among
risk factors and outcome variables. Variables with significant association at 5%
level were further subjected to multivariate analysis at α≤ 0.05. Results: The study showed that out of 156 neonates, 40.4%
(63/156) developed neonatal sepsis. Maternal factors that projected the incidence
of sepsis amongst neonates were distance to nearest health facility [AOR: 6.3 (95%
CI: 1.8 - 21.3), p = 0.003], occupation [AOR: 5.8 (95% CI: 1.2 - 27.6), p = 0.026],
number of antenatal visits [AOR: 6.3 (95% CI: 1.9 - 21.6), p =
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