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Risk Factors for Mortality in Acute Kidney Injury in Intensive Care Units in Togo

DOI: 10.4236/ojneph.2024.141005, PP. 37-47

Keywords: AKI, Intensive Care Unit, Dialysis, Epidemiology, Togo

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Abstract:

Context: Acute kidney injury (AKI) in intensive care unit (ICU) is common and associated with very high mortality. In Togo, a tropical country with limited resources and only one nephrology department in the north, acute kidney injury seems to be a real tragedy with high mortality. Aims: to determine risk factors for mortality in acute kidney injury in the intensive care units. Methods and Material: We made a multicentric cross sectional study during 6 months in the four referral centers in northern Togo. Univariate and multivariate logistic regression was used to identify factors associated with mortality. Data were analyzed using RStudio 2023.04.1. Results: A total of 12.6% of patients admitted to intensive care had presented with AKI. The mean age was 49.6 ± 17.9. The sex ratio (M/F) was 2.1. Community-acquired AKI was in the majority (67.7%). Oligo anuria was the most frequent functional sign (38.4%). In our series, 81.6% of patients were in KDIGO stages 2 to 3. AKI was organic in 56.2% of cases. Mortality was 44.3%. In multivariate analysis, the main factors predictive of death were: respiratory distress (OR = 2.36; p < 0.001), altered consciousness (OR = 2.12; p = 0.004), MAP < 60 mmHg (OR = 1.89; p = 0.004), hemorrhage as etiology (OR = 2.71; p = 0.004) and number of visceral failures (OR = 1.79; p < 0.001). Conclusions: Acute kidney injury in intensive care is common in northern Togo, and mortality is high. Identification of associated factors should help anticipate prognosis.

References

[1]  Hoste, E.A.J., Bagshaw, S.M., Bellomo, R., Cely, C.M., Colman, R., Cruz, D.N., et al. (2015) Epidemiology of Acute Kidney Injury in Critically Ill Patients: The Multinational AKI-EPI Study. Intensive Care Medicine, 41, 1411-1423.
https://doi.org/10.1007/s00134-015-3934-7
[2]  Okunola, O., Akinsola, A. and Ayodele, O. (2012) Kidney Diseases in Africa: Aetiological Considerations, Peculiarities and Burden. African Journal of Medicine and Medical Sciences, 41, 119-133.
[3]  Raimann, J.G., Riella, M.C. and Levin, N.W. (2018) International Society of Nephrology’s 0by25 Initiative (Zero Preventable Deaths from Acute Kidney Injury by 2025): Focus on Diagnosis of Acute Kidney Injury in Low-Income Countries. Clinical Kidney Journal, 11, 12-19.
https://doi.org/10.1093/ckj/sfw134
[4]  Banda, J., Chenga, N., Nambaya, S., Bulaya, T. and Siziya, S. (2020) Predictors of Acute Kidney Injury and Mortality in Intensive Care Unit at a Teaching Tertiary Hospital_ID. Indian Journal of Critical Care Medicine, 24, 116-121.
https://doi.org/10.5005/jp-journals-10071-23352
[5]  Aniort, J., Heng, A.-é., Deteix, P., Souweine, B. and Lautrette, A. (2019) épidémiologie de l’insuffisance rénale aiguë Epidemiology of acute renal failure. Néphrologie & Thérapeutique, 15, 63-69.
https://doi.org/10.1016/j.nephro.2018.11.002
[6]  Jacobs, F.-M. and Brivet, F.-G. (2005) épidémiologie et pronostic des insuffisances rénales aiguës en réanimation. Réanimation, 14, 472-482.
https://doi.org/10.1016/j.reaurg.2005.09.011
[7]  Bennis, L., Derkaoui, A., Shimi, A. and Khatouf, M. (2020) Insuffisance renale aigue en milieu de reanimation a propos de 40 cas n.d. IOSR Journal of Nursing and Health Science, 9, 41-46.
[8]  Touré, A. (2022) Insuffisance rénale aigue en réanimation: facteurs étiologiques et pronostiques dans le CHU-Gabriel Touré. Ph.D. Thesis, Université des Sciences, des Techniques et des Technologies de Bamako, Bamako.
[9]  Cerdá, J., Mohan, S., Garcia-Garcia, G., Jha, V., et al. (2017) Acute Kidney Injury Recognition in Low- and Middle-Income Countries. Kidney International Reports, 2, 530-543.
https://doi.org/10.1016/j.ekir.2017.04.009
[10]  Ariarajah, N., Gerstel, E. and Ponte, B. (2011) Biomarqueurs dans l’insuffisance rénale aiguë. Revue Médicale Suisse, 284, 490-494.
[11]  Santos, P.R. and Monteiro, D.L.S. (2015) Acute Kidney Injury in an Intensive Care Unit of a General Hospital with Emergency Room Specializing in Trauma: An Observational Prospective Study. BMC Nephrology, 16, 30.
https://doi.org/10.1186/s12882-015-0026-4
[12]  Moghal, N.E., Brocklebank, J.T. and Meadow, S.R. (1998) A Review of Acute Kidney Injury in Children: Incidence, Etiology and Outcome. Clinical Nephrology, 49, 91-95.
[13]  Abd ElHafeez, S., Tripepi, G., Quinn, R., Naga, Y., Abdelmonem, S., AbdelHady, M., et al. (2017) Risk, Predictors, and Outcomes of Acute Kidney Injury in Patients Admitted to Intensive Care Units in Egypt. Scientific Reports, 7, Article ID: 17163.
https://doi.org/10.1038/s41598-017-17264-7
[14]  Cosentino, F., Chaff, C. and Piedmonte, M. (1994) Risk Factors Influencing Survival in ICU Acute Renal Failure. Nephrol Dial Transplant, 4, 179-182.
[15]  Olowu, W.A., Niang, A., Osafo, C., Ashuntantang, G., Arogundade, F.A., Porter, J., et al. (2016) Outcomes of Acute Kidney Injury in Children and Adults in Sub-Saharan Africa: A Systematic Review. The Lancet Global Health, 4, e242-250.
https://doi.org/10.1016/S2214-109X(15)00322-8
[16]  Traoré, B. (2008) Assurance qualité de soins en Anesthésie Réanimation. Ph.D. Thesis, Université de Bamako, Bamako.
[17]  Aylward, R.E., van der Merwe, E., Pazi, S., van Niekerk, M., Ensor, J., Baker, D., et al. (2019) Risk Factors and Outcomes of Acute Kidney Injury in South African Critically Ill Adults: A Prospective Cohort Study. BMC Nephrology, 20, 460.
https://doi.org/10.1186/s12882-019-1620-7
[18]  Amekoudi, E.M.Y.Y., Sabi, K.A. and Tchamdja, T. (2022) POS-155 AKI in the North of Togo. Kidney International Reports, 7, S68.
https://doi.org/10.1016/j.ekir.2022.01.168
[19]  Gilbert, A., Robertson, L., Heron, J.E., Chadban, S., et al. (2020) Risk Factors for Development of Acute Kidney Injury in Hospitalised Adults in Zimbabwe. PloS One, 15, e0241229.
https://doi.org/10.1371/journal.pone.0241229
[20]  Traoré, L. (2014) Insuffisance rénale aiguë en réanimation facteurs etiologiques et pronostics: etude prospective. Ph.D. Thesis, Universite de Bamako, Bamako.
[21]  Khwaja, A. (2012) KDIGO Clinical Practice Guidelines for Acute Kidney Injury. Nephron Clinical Practice, 120, c179-84.
https://doi.org/10.1159/000339789
[22]  Lengani, A., Kargougou, D., Fogazzi, G.B. and Laville, M. (2010) L’insuffisance rénale aiguë au Burkina Faso. Néphrologie & Thérapeutique, 6, 28-34.
https://doi.org/10.1016/j.nephro.2009.07.013
[23]  Liaño, F. and Pascual, J. (1996) Epidemiology of Acute Renal Failure: A Prospective, Multicenter, Community-Based Study. Kidney International, 50, 811-818.
https://doi.org/10.1038/ki.1996.380
[24]  Schetz, M., Dasta, J., Goldstein, S. and Golper, T. (2005) Drug-Induced Acute Kidney Injury. Current Opinion in Critical Care, 11, 555-565.
https://doi.org/10.1097/01.ccx.0000184300.68383.95
[25]  Jha, V. and Parameswaran, S. (2013) Community-Acquired Acute Kidney Injury in Tropical Countries. Nature Reviews Nephrology, 9, 278-290.
https://doi.org/10.1038/nrneph.2013.36
[26]  Olowu, W.A. (2015) Acute Kidney Injury in Children in Nigeria. Clinical Nephrology, 83, 70-74.
https://doi.org/10.5414/CNP83S070

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