Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077); hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p < 0.00001) in patients over 45 years of age. Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.
References
[1]
World Health Organization (2023) Non Communicable Diseases. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
[2]
Fourcade, L. (2007) Transition épidémiologique et développement: L’essor des maladies non transmissibles est-il une fatalité. Médecine Tropicale, 67, 543-544.
[3]
World Health Organization (2023) Number of Deaths Attributed to Non-Communicable Diseases, by Type of Disease and Sex. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/number-of-deaths-attributed-to-non-communicable-diseases-by-type-of-disease-and-sex
[4]
Kannel, W.B. (1971) Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease: The Framingham Study. Annals of Internal Medicine, 74, 1-12. https://doi.org/10.7326/0003-4819-74-1-1
[5]
Bonnechère, B., Samadoulougou, S., Cisse, K., Tassembedo, S., Kouanda, S. and Kirakoya-Samadoulougou, F. (2022) Alcohol Consumption and Associated Risk Factors in Burkina Faso: Results of a Population-Based Cross-Sectional Survey. BMJ Open, 12, e058005. https://doi.org/10.1136/bmjopen-2021-058005
[6]
Dabilgou, A.A., Dravé, A., Kyelem, J.M.A., Ouedraogo, S., Napon, C. and Kaboré, J. (2020) Frequency and Mortality Risk Factors of Acute Ischemic Stroke in Emergency Department in Burkina Faso. Stroke Research and Treatment, 2020, Article ID: 9745206. https://doi.org/10.1155/2020/9745206
[7]
Kaboré, S., Millogo, T., Soubeiga, J.K., Lanou, H., Bicaba, B. and Kouanda, S. (2020) Prevalence and Risk Factors for Overweight and Obesity: A Cross-Sectional Countrywide study in Burkina Faso. BMJ Open, 10, e032953. https://doi.org/10.1136/bmjopen-2019-032953
[8]
Séré, L., Tiéno, H., Yanogo, D., Traoré, S., Nagabila, Y., Ouédraogo, D.D., et al. (2021) Prévalence du Diabète et Facteurs de Risque Cardiovasculaire Associés dans une Population Rurale au Burkina Faso. MSc Médecine Tropicale & Santé Internationale, 1, B1J8-7K63. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022753/
[9]
Yaméogo, N.V., Samadoulougou, A.K., Kagambèga, L.J., Millogo, G.R., Yaméogo, A., et al. (2014) [Epidemiological Characteristics and Clinical Features of Black African Subject’s Resistant Hypertension]. Annales de Cardiologie et d’Angéiologie, 63, 83-88. https://pubmed.ncbi.nlm.nih.gov/24492012/
[10]
Diallo, I., Meda, N., Ouédraogo, S., Poda, A., Hema, A., Sagna, Y., et al. (2017) Profiles of Elderly People Infected with HIV and Response to Antiretroviral Treatment in Burkina Faso: A Retrospective Cohort Study. International Association of Providers of AIDS Care, 16, 405-411. https://pubmed.ncbi.nlm.nih.gov/28571520/
[11]
Karfo, R., Kangambega, F.M., Kabre, E., Paulette, O., Nacro, Z., Sanogo, Z., et al. (2020) Prevalence of Dyslipidemia in a Burkinabe Military Population. African Journal of Biochemistry Research, 14, 1-4. https://academicjournals.org/journal/AJBR/article-full-text/CAC4DA362702
[12]
Sawadogo, N., Ouedraogo, S., Bamouni, J., Ouedraogo, W.M.E., Kabre, W.J. and Guira, O. (2023) Profil Lipidique des Patients Diabétiques et Obèses au Centre Hospitalier Universitaire Régional d’Ouahigouya: Profil lipidique des patients diabétiques et obèses à Ouahigouya. Health Sciences and Disease, 24, 23-27. http://www.hsd-fmsb.org/index.php/hsd/article/view/4369
[13]
Expert Panel On Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). The Journal of the American Medical Association, 285, 2486-2497. http://jama.ama-assn.org/cgi/doi/10.1001/jama.285.19.2486
[14]
Hamed, N., Soliman, A., De Sanctis, V., Alaaraj, N., Alyafei, F., Shaat, M., et al. (2021) The Prevalence of the Different Components of the Metabolic Syndrome (MetS) in Obese Nondiabetic Children and Young Adolescents and Their Anthropometric Data in Relation to Parents. Acta Biomedica Atenei Parmensis, 92, e2021321. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477109/
[15]
Cissé, F., Agne, F.D., Diatta, A., Mbengue, A.S., Ndiaye, A., Samba, A., et al. (2016) Prévalence des dyslipidémies au laboratoire de biochimie du CHU Aristide le Dantec de Dakar, Sénégal. The Pan African Medical Journal, 25, Article 67. https://doi.org/10.11604/pamj.2016.25.67.7758
[16]
Tiahou, G., Deret, K., Monde, A., Camara-Cisse, M., Djohan, Y., et al. (2010) Fréquence des bilans lipidiques et prévalence des dyslipidémies au Laboratoire de biochimie du CHU de Cocody. Journal of Pharmaceutical and Biological Sciences, 11, 60-65.
[17]
Mahamat-Azaki, O., Zakaria, A.M.Z., Ali, A.A., Mahamat, Y.K., Jarius, Y.R., Khamiss, H., et al. (2023) Prévalence des dyslipidémies au laboratoire de biochimie du CHU la Référence Nationale de N’Djamena/Tchad. Annales de Cardiologie et d’Angéiologie, 72, Article ID: 101605. https://www.sciencedirect.com/science/article/pii/S0003392823000409
[18]
Hassing, H.C., Surendran, R.P., Mooij, H.L., Stroes, E.S., Nieuwdorp, M. and Dallinga-Thie, G.M. (2012) Pathophysiology of Hypertriglyceridemia. Biochimica et Biophysica Acta (BBA)—Molecular and Cell Biology of Lipids, 1821, 826-832. https://linkinghub.elsevier.com/retrieve/pii/S138819811100254X
[19]
Turpin, G. and Bruckert, E. (1990) Aspects génétiques et physiopathologiques des dyslipoprotéinémies athérogènes. La Revue de Médecine Interne, 11, 478-484. https://www.sciencedirect.com/science/article/pii/S0248866305812263
[20]
Ben Hdia, Z., Ben Abdelaziz, A., Melki, S., Ben Hassine, D., Ben Rejeb, N., Omezzine, A., et al. (2022) Epidémiologie de la dyslipidémie en Tunisie. Etude Hammam Sousse Sahloul Heart Study (HSHS 3)*. Tunis Médicale, 100, 323-334. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9477151/
[21]
Al-maqati, T.N., Gazwani, A.M., Taha, M., Almusabi, S., Elnagi, E.A., Maawadh, R.M., et al. (2022) The Impact of Age, Gender, and Fasting Blood Glucose on the Serum Lipid Profile at a Tertiary Care Hospital: A Retrospective Study. Acta Biomedica Atenei Parmensis, 93, e2022341. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828901/
[22]
Savadogo, H., Coulibaly, G., Koueta, F., Ouedraogo-Yugbare, S.O., Kabore, A., Dao, L., et al. (2015) Management of Nephrotic Syndrome in Children in Burkina Faso. A Major Challenge in the Context of Limited Resources. Médecine d’Afrique Noire, 62, 150-158. https://www.cabidigitallibrary.org/doi/full/10.5555/20153119124
[23]
Centre Hospitalier Universitaire Pediatrique Charles De Gaulle (2021) Annuaire statistique 2020. https://hopitalpediatrique.bf/IMG/pdf/annuaire_statistique_2020__chup-cdg_vf-2.pdf
[24]
Baguiya, A., Coulibaly, I., Coulibaly, A., Garanet, F., Nikiema, L. and Kouanda, S. (2018) Prévalence et facteurs associés à la consommation de cigarette et d’alcool par les élèves dans 24 villes du Burkina Faso: Une étude transversale. Annales de l’Université Ouaga 1 Professeur Joseph Ki-Zerbo, Série D, 20, 11-29.
[25]
Liu, H.H. and Li, J.J. (2015) Aging and Dyslipidemia: A Review of Potential Mechanisms. Ageing Research Reviews, 19, 43-52. https://linkinghub.elsevier.com/retrieve/pii/S1568163714001287
