Purpose: The study was to evaluate the efficacy of cyanoacrylate tissue adhesive
(CTA) application in corneal perforations. Method: This was a
prospective study on 20 patients of corneal perforations who received
cyanoacrylate tissue adhesive application as treatment between March 2021 and
March 2022 at Preah Ang Duong Hospital. The primary outcome measure was success
rate of CTA application, while the secondary outcome was to measure
postoperative best-corrected visual acuity (BCVA) and ocular complications. Results: The mean age of patients was 44.15 ± 16.05 years old and 7 (35%) were female. Causes of perforation were
microbial infection in 12 patients (60%), trauma in 5 patients (25%), and
sterile melting in 3 patients (15%). The perforation of size smaller than 1.5mm was
in 8 patients (40%) while 12 patients (60%) had perforated size between 1.5mm to 3mm. The
perforation was 60% (12 patients) central, 25% (5 patients) paracentral, and
15% (3 patients) peripherally. Out of 20 patients, 5 patients (25%) received
CTA application more than 1 time. The mean glue retention was 57.60 ± 31.84 days. Success rate of glue application (defined as intact globe
without surgical intervention regardless of number of CTA applications) was
85%. At the last visit, 7 patients (35%) had BCVA of 6/120 or better. Common complications
were uveitis (45%), ocular hypertension (30%), cataract (25%) and
neovascularization (20%). No serious complications were found. Conclusion: Cyanoacrylate
tissue adhesive is an effective treatment option in sealing corneal
perforations with no serious complications.
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