Non-melanoma skin cancers or keratinocyte cancers such as basal cell
carcinoma and squamous cell carcinoma make up approximately 80% and 20%
respectively, of skin cancers with the 6 million people that are treated
annually in the United States. 1 in 5 Americans and 2 in 3 Australians develop
skin cancer by the age of 70 years and in Australia it is the most expensive,
amassing $1.5 billion, to treat cancers. Non-melanoma skin cancers are often
self-detected and are usually removed by various means in doctors’ surgeries. Mohs micrographic surgery is acclaimed
to be the gold standard for the treatment of skin cancer. However, a novel
microscopic molecular-cellular non-invasive topical therapy described in this
article, challenges the status of Mohs procedure for being the acclaimed gold
standard.
References
[1]
Kao, S.Y., Ekwueme, D.U., Holman, D.M., Rim, S.H., Thomas, C.C. and Saralya, M. (2022) Economic Burden of Skin Cancer Treatment in the United States: An Analysis of the Medical Expenditure Panel Survey Data, 2012-2018. Cancer Causes & Control, 34, 205-212. https://doi.org/10.1007/s10552-022-01644-0
[2]
Cancer Statistics Working Group (2022) U.S. Cancer Statistics Data Vizualisations Tool, Based on 2021 Submission Data (1999-2019): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute. https://www.cdc.gov/cancer/dataviz
[3]
Cancer Council NSW (2021) Surgery for Skin Cancer.
[4]
Patent WO1991010743A1.
[5]
Cham, B.E. and Wilson, L. (1987). HPLC of Glycoalkaloids from Solanum sodomaeum L. Planta Medica, 53, 59-61. https://doi.org/10.1055/s-2006-962621
[6]
Daunter, B. and Cham, B.E. (1990) Solasodine Glycosides. In Vitro Preferential Cytotoxicity for Human Cancer Cells. Cancer Letters, 55, 209-220.
https://doi.org/10.1016/0304-3835(90)90121-D
[7]
Cham, B.E. (2013) Drug Therapy: Solamargine and Other Solasodine Rhamnosylglycosides as Anticancer Agents. Modern Chemotherapy, 2, 33-49.
https://doi.org/10.4236/mc.2013.22005
[8]
Cham, B.E. (1988) Monograph on the Compound BEC. Drugs of the Future, 13, 714-716. https://doi.org/10.1358/dof.1988.013.08.63026
[9]
Millward, M., Powell, A., Daly, P., Tyson, R., Ferguson, R. and Carter, S. (2006) Results of Phase I Clinical Trials of Coramsine in Patients with Advanced Solid Tumours. Journal Clinical Oncology, 24, 2070.
https://doi.org/10.1200/jco.2006.24.18_suppl.2070
[10]
Millward, M., Powell, A., Tyson, S., Daly, P., Ferguson, R. and Carter, S. (2005) Phase I Trial of Coramsine (SBP002) in Patients with Advanced Solid Tumours. Journal Clinical Oncology, 23, 3105.
https://doi.org/10.1200/jco.2005.23.16_suppl.3105
[11]
Cham, A., Cham, K., Chase, T. and Cham, B. (2015) A Standardized Plant Extract Containing a Target Compound Is Acceptable as a Potent Therapeutic Entity: Relevance to BEC and Solamargine, a Topical Clinical Formulation CuradermBEC5. Journal Cancer Treatment and Research, 3, 22-27.
https://doi.org/10.11648/j.jctr.20150302.12
[12]
Cham, B.E. and Daunter, B. (1990) Solasodine Glycosides. Selective Cytotoxicity for Cancer Cells and Inhibition of Cytotoxicity by Rhamnose in Mice with Sarcoma 180. Cancer Letters, 55, 221-225. https://doi.org/10.1016/0304-3835(90)90122-E
[13]
Cham, B.E. (2007) Solasodine Rhamnosyl Glycosides Specifically Bind Cancer Cell Receptors and Induce Apoptosis and Necrosis. Treatment for Skin Cancer and Hope for Internal Cancers. Research Journal of Biological Sciences, 2, 503-514.
[14]
Cham, B.E. (1994) Solasodine Glycosides as Anticancer Agents: Preclinical and Clinical Studies. Asia Pacific Journal of Pharmacology, 9, 113-118.
[15]
Li, X., Zhao, Y., Wu, W.K., Liu, S., Cui, M. and Lou, H. (2011) Solamargine Induces Apoptosis with p53 Transcription-Dependent and Transcription-Independent Pathways in Human Osteosarcoma U2OS Cells. Life Sciences, 88, 314-321.
https://doi.org/10.1016/j.lfs.2010.12.006
[16]
Al Sinani, S.S., Eltayeb, E.A., Coomber, B.L. and Adham, S.A. (2016) Solamarginetriggers Cellular Necrosis Selectively in Different Types of Human Melanoma Cancercells through Extrinsic Lysosomal Mitochondrial Death Pathways. Cancer Cell International, 16, Article No. 11. https://doi.org/10.1186/s12935-016-0287-4
[17]
Zang, X., Yan, Z., Xu, T., An, Z., Chen, W., Wang, X., Huang, M. and Zhu, F. (2018) SM Derived from Solanum nigrum Induces Apoptosis of Human Cholangio Carcinoma QBC939 Cells. Oncology Letters, 15, 6329-6335.
https://doi.org/10.3892/ol.2018.8171
[18]
Al Sinani, S.S.S. and Eltayeb, E.A. (2017) The Steroidal Glycoalkaloids Solamargineand Solasonine in Solanum Plants. South African Journal of Botany, 112, 253-269. https://doi.org/10.1016/j.sajb.2017.06.002
[19]
Kalalinia, F. and Korimi-Sani, I. (2017) Anticancer Properties of Solamargine: A Systematic Review. Phytotherapy Research, 31, 858-870.
[20]
Sani, I.K., Marashi, S.H. and Kalalinia, F. (2015) Solamargine Inhibits Migrationand Invasion of Human Hepatocellular Carcinoma Cells through Down-Regulation of Matrix Metalloproteinases 2 and 9 Expression and Activity. Toxicology in Vitro, 29, 893-900. https://doi.org/10.1016/j.tiv.2015.03.012
[21]
Li, X., Zhao, Y., Liu, S., Cui, M. and Lou, H. (2011) Induction of Actin Disruptionand Downregulation of P-Glycoprotein Expression of Solamargine in Multidrug-Resistant K562/A02 Cells. Chinese Medical Journal, 124, 2038-2044.
[22]
Cham, B.E. and Meares, H.M. (1987) Glycoalkaloids from Solanum Sodomaeum Are Effective in the Treatment of Skin Cancers in Man. Cancer Letters, 36, 111-118.
https://doi.org/10.1016/0304-3835(87)90081-4
[23]
Cham, B.E., Daunter, B. and Evans, R. (1991) Topical Treatment of Malignant and Premalignant Skin Lesions by Very Low Concentrations of a Standard Mixture (BEC) of Solasodine Glycosides. Cancer Letters, 59, 183-192.
https://doi.org/10.1016/0304-3835(91)90140-D
[24]
Cham, B.E. (2022) The Pharmacology of Curaderm in the Treatment of Basal CellCarcinoma. Clinical Medical Review and Case Reports, 9, Article 399.
https://doi.org/10.23937/2378-3656/1410399
[25]
Chase, T.R., Cham, K.E. and Cham, B.E. (2024) The Value of Excipients and the Required Understanding of the Biological System in Product Development: An Impactful Example of Curaderm, a Topical Skin Cancer Treatment. International Journal of Clinical Medicine, 15, 68-87 https://doi.org/10.4236/ijcm.2024.152005
[26]
Punjabi, S., Cook, L.J., Kersey, P., Marks, R. and Cerio, R. (2008) Solasodine Glycoalkaloids: A Novel Topical Therapy for Basal Cell Carcinoma. A Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Multicentre Study. International Journal of Dermatology, 47, 78-82.
https://doi.org/10.1111/j.1365-4632.2007.03363.x
[27]
Cham, B.E. (2013) Solasodine Glycosides: A Topical Therapy for Actinic Keratosis. A Single-Blind, Randomized, Placebo-Controlled, Parallel Group Study with CuradermBEC5. Journal of Cancer Therapy, 4, 588-596.
https://doi.org/10.4236/jct.2013.42076
[28]
Cham, B.E., Gilliver, M. and Wilson, L. (1987) Antitumour Effects of Glycoalkaloids Isolated from Solanum sodomaeum L. Planta Medica, 53, 34-36.
https://doi.org/10.1055/s-2006-962612
[29]
Cham, B.E. (2023) Holistic Approach in the Treatment of Actinic Keratosis: Benefits and Disadvantages of 5-Fluorouracil, Imiquimod, Diclofenac and Curaderm. International Journal of Clinical Medicine, 14, 319-331.
https://doi.org/10.4236/ijcm.2023.147027
[30]
Dobrokhotova, F.Z., Betzev, A.E. and Belysheva, T.S. (2016) The Use of Kuraderm Drug in the Treatment of Basal Cell Carcinoma of the Head and Neck. Head and Neck Tumors, 6, 22-26. https://doi.org/10.17650/2222-1468-2016-6-3-22-26
[31]
Batsev, A.E., Dobrokhotova, V.Z. and Cham, B.E. (2016) Topical Cream Curadermbec5 Treats a Recalcitrant Basal Cell Carcinoma. Clinical Medical Reviews and Case Reports, 3, Article ID: 098. https://doi.org/10.23937/2378-3656/1410098
[32]
Chase, T., Cham, K.E. and Cham, B.E. (2020) Curaderm, the Long-Awaited Breakthrough for Basal Cell Carcinoma. International Journal of Clinical Medicine, 11, 579-604. https://doi.org/10.4236/ijcm.2020.1110050
[33]
Cham, B.E. (2014) A Review of Solasodine Rhamnosides Therapy for in-Situ Squamous Cell Carcinoma of the Penis. British Journal of Medicine and Medical Research, 4, 621-631. https://doi.org/10.9734/BJMMR/2014/4677
[34]
Goldberg, L.H., Landau, J.M., Moody, M.N. and Vergilis-Kalner, I. (2011) Treatment of Bowen’s Disease on the Penis with Low Concentrations of a Standard Mixture of Solasodine Glycosides and Liquid Nitrogen. Dermatologic Surgery, 37, 858-861. https://doi.org/10.1111/j.1524-4725.2011.02014.x
[35]
Yu, S., Sheu, H.M. and Lee, C.H. (2017) Solanum incanum Extract (SR-T100) Induces Melanoma Cell Apoptosis and Inhibits Established Lung Metastasis: A Case Report. Oncotarget, 8, 103509-103517. https://doi.org/10.18632/oncotarget.21508
[36]
Cham, B.E. (2020) First in Man Topical Treatment of Melanoma with Solasodine Glycosides in a Formulation Curaderm. Journal of Cancer Therapy, 11, 617-630.
https://doi.org/10.4236/jct.2020.1110052
[37]
Wang, Y., Gao, J., Gu, G., Li, G., Cui, C., et al. (2011) In Situ RBL Receptor Visualization and Its Mediated Anticancer Activity for Solasodine Rhamnosides. ChemBioChem, 12, 2418-2420. https://doi.org/10.1002/cbic.201100551
[38]
Kokkinos, C., Kanapathy, M., Heydari, S., Hamilton, S. and Withey, S. (2022) Waiting Time for Mohs Micrographic Surgery and the Associated Increase in Lesion Size of Basal Cell Carcinoma. Journal of Plastic, Reconstructive & Aesthetic Surgery, 75, 3384-3389. https://doi.org/10.1016/j.bjps.2022.05.001
