Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensisseed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p < 0.001) fasting blood glucose from 129.4 ± 6.4 mg/dL to 66.0 ± 5.3 mg/dL at the dose 500 mg/kg. This dose was found to exert greater effects in lowering blood sugar levels compared to other doses. For the lipid profile the same significant decrease (p < 0.001) was observed in triglycerides which went from 71.4 ± 1.1 versus 47.4 ± 0.9 mg/dL and LDL cholesterol which went from 36 .9 ± 1.5 versus 17.4 ± 1.2 mg/dL. On oxidative stress, the MDA level decreased significantly from 2.64 ± 0.01 versus 1.34 ± 0.10 μM. We can affirm on the basis of the results that the aqueous extract of B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.
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