Introduction: About 10 to
15% of couples in the world and 20 to 30% in Cameroon consult for infertility
problems. Infertility is of male origin in 40% of cases. Our objective was to
evaluate the epidemiological and clinical aspects of male infertility in our
setting. Methods: This was a cross-sectional and descriptive study, with
retrospective data collection from the files of patients received for male
infertility, over 5 years and 6 months (from January 1st, 2016 to
April 30th, 2021) at the Urology Department of the Yaounde Central
Hospital. Phone calls were made to patients with incomplete records for
completion following a verbal consent. Data reported on data collection forms
were entered into a data entry form designed on CSPro software version 7.2. The
database was later exported for descriptive statistics using the IBM SPSS
software version 23. Qualitative variables were summarized in frequencies and
percentages while quantitative variables were summarized in means with their
standard deviations for normally distributed data, or medians and interquartile
ranges otherwise. Results: Out of 110 patients whose records were analyzed, the
median age was 37.0 years, with an interquartile range of 8.3, with 55.5% in
the age group 30 to 39 years. Of these 95 (86.4%) were married, 58 (52.7%) were
from the West region, 76 (69.1%) were employed. Past history was dominated by
mumps 40 (36.4%), varicocele surgery 25 (22.7%), alcoholism 87 (79.1%) and
smoking 15 (13.6%). A disorder of spermatogenesis was found in all our
patients: 37 (33.6%) azoospermia, 27 (24.6%) asthenospermia and 26 (23.7%)
oligospermia patients. Paraclinical evidence of chlamydia and gonococcal
infections were found respectively in 38 (34.5%) and 14 (12.7%) patients,
varicocele and testicular dystrophy respectively in 95 (86.4%) and 38 (34.5%) patients.
Infertility was primary in 67 (60.9%) patients. Conclusion: Most patients with
infertility were in their thirties, had risky social habits and comorbidities.
An early start of health promotion activities, comorbidities prevention and
early detection of spermogram abnormalities would make it possible to reduce
the frequency of male infertility.
References
[1]
Noubom, A. (2016) Aspects étiologiques et thérapeutiques de l’infertilité du couple au CHRACERH/HGY. Health Sciences and Diseases, 17.
[2]
Gaskins, J. and Chavarro, J. (2018) Diet and Fertility: A Review. American Journal of Obstetrics & Gynecology, 218, 379-389.
https://doi.org/10.1016/j.ajog.2017.08.010
[3]
Mascarenhas, M.N., Flaxman, S.R., Boerma, T., Vanderpoel, S. and Stevens, G.Z. (2012) National, Regional and Global Trends in Infertility Prevalence since 1990: A Systematic Analysis of 277 Health Surveys. PLOS Medicine, 9, e101356.
https://www.plosmedicine.org
https://doi.org/10.1371/journal.pmed.1001356
[4]
Heffner, L. (2003) Reproduction Humaine. De Boeck, Bruxelles.
[5]
Larsen, Masenga, U.G. and Mlay, I. (2003) Infertility in a Community and Clinic/Based Sample of Couples in Moshi, Northern Tanzania. East African Medical Journal, 83, 10-17. https://doi.org/10.4314/eamj.v83i1.9355
[6]
Olatunji, A.O. and Sule-Odu, A.O. (2003) The Pattern of Infertility Cases at a University Hospital. West African Journal of Medicine, 22, 205-207.
https://doi.org/10.4314/wajm.v22i3.27950
[7]
Longe, J. (2006) The Gale Encyclopedia of Medicine. 3rd Edition, Thomson Gale, Farmington Hills.
[8]
Sankaré, O. (2004-2005) Contribution à l’étude des aspects étiologiques de l’infertilité masculine au service de cytogénétique et de biologie de la reproduction de l’INRSP. Bamako. Thèse de Medicine, Faculté de Médecine, de Pharmacie et d’Odontostomatologie, Bamako, 86 p.
[9]
Spira, A. (1986) Epidemiology of Human Reproduction. Human Reproduction, 1, 111-115. https://doi.org/10.1093/oxfordjournals.humrep.a136353
[10]
Niang, L., Ndoye, M., Labou, I., Jalloh, M., Kane, R., Diaw, J.J., et al. (2009) Profil épidémiologique et clinique de l’infertilité Masculine à l’hopital général de grand Yoff, Sénégal: à propos de 492 cas. Basic and Clinical Andrology, 19, 103-107.
https://doi.org/10.1007/s12610-009-0019-x
[11]
Fizazi, A. (2014) Evaluation de l’infertilité masculine dans l’Ouest Algérien: étude épidémiologique et biologique. Thèse de Medicine, Université Djillaliliabés de Sidi Bel Abbes, Algérie, 139.
[12]
Nana, P.N., Wandji, J.C., Fomulu, J.N., Mbu, R.E., Leke, J.R. and Woubinwou, M.J. (2011) Aspects psychosociaux chez les patients infertiles à la maternité principale de l’hôpital central de Yaoundé, Cameroun. Clinics in Mother and Child Health, 8, C100601. https://doi.org/10.4303/cmch/C100601
[13]
Nana, N.T., Tiba, T.F., Djiukam, T.H.L., Etongue, M.F., Sandjon, G., Fomulu, N., et al. (2007) Facteurs Associés à L’infertilite Masculine: Résultats d’une série de 84 patients suivis à l’Hôpital Général de Yaoundé. Clinics in Mother and Child Health, 4, 665-670.
[14]
Argawal, A., Mulgund, A., Hamada, A. and Chyatte, M.R. (2015) A Unique View on Male Infertility around the Globe. Reproductive Biology and Endocrinology, 13, Article No. 37. https://doi.org/10.1186/s12958-015-0032-1
[15]
Copperman, E. and Soto, A.B. (2011) Factors Affecting Fertility in Gynecology in Practice. Blackwell, Hoboken. https://doi.org/10.1002/9781444393958.ch1
[16]
Darcq, C. and Hermabessiere, J. (2006) Etiologie des infertilités secondaires de l’homme. Andrologie, 16, 155-159. https://doi.org/10.1007/BF03034847
[17]
El hajjami, H. (2017) Infertilité masculine: Profil épidémiologique et clinique. Thèse Medicine, Faculté de médecine, et de pharmacie, Fès, 205.
[18]
Guo, D., Li, S., Behr, B. and Einsenberg, M.L. (2017) Hypertension and Male Fertility. World Journal of Men’s Health, 35, 59-64.
https://doi.org/10.5534/wjmh.2017.35.2.59
[19]
Ding, G.L., Liu, Y., Liu, M.E., Pan, J.X., Guo, M.X., Sheng, J.Z., et al. (2015) The Effects of Diabetes on Male Infertility and Epigenetic Regulation during Spermatogenesis. Asian Journal of Andrology, 17, 948-953.
https://doi.org/10.4103/1008-682X.150844
[20]
Mohammed, F., Mostafa, B., Jalal, K., Yassine, B., Omar, C., Malika, B., et al. (2021) Prévalence de l’infertilité masculine dans un hôpital universitaire au Maroc. Pan African Medical Journal, 38, Article No. 46.
[21]
Gueye, S.M., et al. (1999) Influence de la cure chirurgicale de la varicocèle sur la qualité du sperme. Andrologie, 9, 376-379. https://doi.org/10.1007/BF03034810
[22]
Sepaknias, F.T., Fontaine, B., Gerard, H., Guillet-May, E., et al. (2004) Impact négatif du tabac sur la fertilitéMasculine: Des spermatozoïdes à la descendance. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 33, 387-390.
https://doi.org/10.1016/S0368-2315(04)96545-3
[23]
Cohen, J. and Palmer, R. (1979) Stérilité masculine abrégée stérilité conjugale. Paris-Masson.
[24]
Gainsi, E., Fourn, L. and Akpo, C. (1990) Stérilité masculine et infection urétrale au CNHU de Cotonou. Médécine d’Afrique Noire, 37, 472-480.
[25]
Moussa, D., Soumana, A., Amadou, S., Soli, I., Tahirou, I. and Ali, A. (2016) Profil hormonal en cas d’infertilité au laboratoire de radio immunologie de l’Institut des radioisotopes de Niamey. African Journal of Urology, 22, 305-309.
https://doi.org/10.1016/j.afju.2016.01.008
[26]
Noumi, E., Florentin, E.A. and Nanfack (2011) Traditional Health Care of Male Infertility in Bansoa, West Cameroon. International Journal of Pharmaceutical and Bio-Medical Science, 2, 42-50.
[27]
Collège Français des Urologues (2003) Troubles de l’érection (Item 122) 328. Collège Français des urologues.
[28]
Freour, T., Delvigne, A. and Barriere, P. (2010) L’exploration de l’homme du couple infécond. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 39, S45-S52. https://doi.org/10.1016/S0368-2315(10)70030-2
[29]
WHO (1992) The Influence of Varicocèle on Parameters of Fertility in a Large Group of Man Presenting Infertility Clinics. Fertility and Sterility, 57, 1289-1293.
https://doi.org/10.1016/S0015-0282(16)55089-4
[30]
Sermonade, N., Faure, C., Feuzeu, L., Shayeb, A., Bonde, J., Jensen, K., et al. (2013) BMI in Relation to Sperm Count: An Updated Systematic Review: An Collaborative Meta-Analysis. Human Reproduction Update, 19, 221-231.
https://doi.org/10.1093/humupd/dms050