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循环游离DNA在常见肿瘤中的临床应用进展
Advances in the Clinical Application of Circulating Cell-Free DNA in Common Tumors

DOI: 10.12677/MD.2024.141006, PP. 39-44

Keywords: 循环游离DNA,循环肿瘤DNA
Circulating Cell-Free DNA
, Circulating Tumor DNA

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Abstract:

循环游离DNA (cell-free DNA, cfDNA)容易采集和无创的优点使其在肿瘤早期诊断、良恶性鉴别、疗效检测、预后评价等临床应用中受到广泛的关注。此外,cfDNA还可以反映肿瘤大小、肿瘤转移等。为此,本文综述了cfDNA的临床应用,以期为临床疾病的诊断、疗效分析提供帮助。
The advantages of circulating cell-free DNA (cfDNA) are easy to collect and non-invasive, which has attracted extensive attention in clinical applications such as early tumor diagnosis, benign and ma-lignant identification, efficacy detection, and prognosis evaluation. In addition, cfDNA can also re-flect tumor size, tumor metastasis, etc. Therefore, this article reviews the clinical application of cfDNA, in order to provide help for the diagnosis and efficacy analysis of clinical diseases.

References

[1]  Cicchillitti, L., Corrado, G., De Angeli, M., et al. (2017) Circulating Cell-Free DNA Content as Blood Based Biomarker in En-dometrial Cancer. Oncotarget, 8, 115230-115243.
https://doi.org/10.18632/oncotarget.23247
[2]  Fleischhacker, M. and Schimdt, B. (2007) Circulating Nucleic Acids (CNAs) and Cancer-Survey. Biochimica et Biophysica Acta, 1775, 181-232.
https://doi.org/10.1016/j.bbcan.2006.10.001
[3]  Jahr, S., Hentze, H., Englisch, S., et al. (2001) DNA Fragments in the Blood Plasma of Cancer Patients: Quantitations and Evidence for Their Origin from Apoptotic and Necrotic Cells. Cancer Re-search, 61, 1659-1665.
[4]  Pinzani, P., Salvianti, F., Zaccara, S., Massi, D., De Giorgi, V., Pazzagli, M. and Orlando, C. (2011) Circulating Cell-Free DNA in Plasma of Melanoma Patients: Qualitative and Quantitative Considerations. Clinica Chim-ica Acta, 412, 2141-2145.
https://doi.org/10.1016/j.cca.2011.07.027
[5]  Beau-Faller, M., Gaub, M.P., Schneider, A., Ducrocq, X., Massard, G., Gasser, B., Chenard, M.P., Kessler, R., Anker, P., Stroun, M., Weitzenblum, E., Pauli, G., Wihlm, J.M., Quoix, E. and Oudet, P. (2003) Plasma DNA Microsatellite Panel as Sensitive and Tumor-Specific Marker in Lung Can-cer Patients. International Journal of Cancer, 105, 361-370.
https://doi.org/10.1002/ijc.11079
[6]  Liu, P., Liang, H., Xue, L., Yang, C., Liu, Y., Zhou, K. and Jiang, X. (2012) Poten-tial Clinical Significance of Plasma-Based KRAS Mutation Analysis Using the COLD-PCR/TaqMan(?)-MGB Probe Geno-typing Method. Experimental and Therapeutic Medicine, 4, 109-112.
https://doi.org/10.3892/etm.2012.566
[7]  Fan, H., Gai, W., Zhang, L., et al. (2021) Parasite Circulating Cell-Free DNA in the Blood of Alveolar Echinococcosis Patients as a Di-agnostic and Treatment-Status Indicator. Clinical Infectious Diseases, 73, E246-E251.
[8]  Leon, S.A., Shapiro, B., Sklaroff, D.M., et al. (1977) Free DNA in the Serum of Cancer Patients and the Effect of Therapy. Cancer Research, 37, 646-650.
[9]  Shapiro, B., Chakrabarty, M., Cohn, E.M. and Leon, S.A. (1983) Determination of Circulating DNA Levels in Patients with Benign or Malignant Gastrointestinal Disease. Cancer, 51, 2116-2120.
https://doi.org/10.1002/1097-0142(19830601)51:11<2116::AID-CNCR2820511127>3.0.CO;2-S
[10]  Park, M.K., Lee, J.C., Lee, J.W. and Hwang, S.J. (2021) Alu Cell-Free DNA Concentration, Alu Index, and LINE-1 Hypomethylation as a Can-cer Predictor. Clinical Biochemistry, 94, 67-73.
https://doi.org/10.1016/j.clinbiochem.2021.04.021
[11]  Gezer, U., Bronkhorst, A.J. and Holdenrieder, S. (2022) The Util-ity of Repetitive Cell-Free DNA in Cancer Liquid Biopsies. Diagnostics (Basel), 12, Article No. 1363.
https://doi.org/10.3390/diagnostics12061363
[12]  Zhang, Y., Liu, Z., Ji, K., Li, X., Wang, C., Ren, Z., Liu, Y., Chen, X., Han, X., Meng, L., Li, L. and Li, Z. (2021) Clinical Application Value of Circulating Cell-Free DNA in Hepatocellular Carci-noma. Frontiers in Molecular Biosciences, 8, Article ID: 736330.
https://doi.org/10.3389/fmolb.2021.736330
[13]  Ferlay, J., Colombet, M., Soerjomataram, I., et al. (2019) Estimating the Global Cancer Incidence and Mortality in 2018: GLOBOCAN Sources and Methods. International Journal of Cancer, 144, 1941-1953.
https://doi.org/10.1002/ijc.31937
[14]  Wang, W. and Wei, C. (2020) Advances in the Early Diagnosis of Hepatocellular Carcinoma. Genes & Diseases, 7, 308-319.
https://doi.org/10.1016/j.gendis.2020.01.014
[15]  Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Ho-bor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B., Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R.B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. and Bardelli, A. (2015) Clonal Evolution and Resistance to EGFR Blockade in the Blood of Colorectal Cancer Patients. Nature Medicine, 21, 795-801.
https://doi.org/10.1038/nm.3870
[16]  Xu, R.H., Wei, W., Krawczyk, M., Wang, W., Luo, H., Flagg, K., Yi, S., Shi, W., Quan, Q., Li, K., Zheng, L., Zhang, H., Caughey, B.A., Zhao, Q., Hou, J., Zhang, R., Xu, Y., Cai, H., Li, G., Hou, R., Zhong, Z., Lin, D., Fu, X., Zhu, J., Duan, Y., Yu, M., Ying, B., Zhang, W., Wang, J., Zhang, E., Zhang, C., Li, O., Guo, R., Carter, H., Zhu, J.K., Hao, X. and Zhang, K. (2017) Circulating Tumour DNA Methylation Markers for Diagnosis and Prognosis of Hepatocellular Carcinoma. Nature Materials, 16, 1155-1161.
https://doi.org/10.1038/nmat4997
[17]  Cohen, J.D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A.A., Wong, F., Mattox, A., Hruban, R.H., Wolfgang, C.L., Goggins, M.G., Dal Molin, M., Wang, T.L., Roden, R., Klein, A.P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J.T., Browne, J.D., Schoen, R.E., Brand, R.E., Tie, J., Gibbs, P., Wong, H.L., Mansfield, A.S., Jen, J., Hanash, S.M., Falconi, M., Allen, P.J., Zhou, S., Bettegowda, C., Diaz, L.A., Tomasetti, C., Kinzler, K.W., Vogelstein, B., Lennon, A.M. and Papadopoulos, N. (2018) Detection and Localization of Surgically Resectable Cancers with a Multi-Analyte Blood Test. Science, 359, 926-930.
https://doi.org/10.1126/science.aar3247
[18]  Zhang, X.Y. and Zhang, P.Y. (2017) Gastric Cancer: Somatic Genetics as a Guide to Therapy. Journal of Medical Genetics, 54, 305-312.
https://doi.org/10.1136/jmedgenet-2016-104171
[19]  Yu, J. and Zheng, W. (2018) An Alternative Method for Screening Gastric Cancer Based on Serum Levels of CEA, CA19-9, and CA72-4. Journal of Gastrointestinal Cancer, 49, 57-62.
https://doi.org/10.1007/s12029-016-9912-7
[20]  Fan, Y., Shi, M., Chen, S., Ju, G., Chen, L., Lu, H., Chen, J. and Zheng, S. (2019) Analysis of Serum CfDNA Concentration and Integrity before and after Surgery in Patients with Lung Cancer. Cellular and Molecular Biology (Noisy-Le-Grand), 65, 56-63.
https://doi.org/10.14715/cmb/2019.65.6.10
[21]  Zhang, X., Wu, Z., Shen, Q., Li, R., Jiang, X., Wu, J., Li, D., Wang, D., Zou, C., Zhong, Y. and Cheng, X. (2019) Clinical Significance of Cell-Free DNA Concentration and Integrity in Serum of Gas-tric Cancer Patients before and after Surgery. Cellular and Molecular Biology (Noisy-Le-Grand), 65, 111-117.
https://doi.org/10.14715/cmb/2019.65.7.19
[22]  Frattini, M., Gallino, G., Signoroni, S., Balestra, D., Lusa, L., Battaglia, L., Sozzi, G., Bertario, L., Leo, E., Pilotti, S. and Pierotti, M.A. (2008) Quantitative and Qualitative Characterization of Plasma DNA Identifies Primary and Recurrent Colorectal Cancer. Cancer Letters, 263, 170-181.
https://doi.org/10.1016/j.canlet.2008.03.021
[23]  Strickler, J.H., Loree, J.M., Ahronian, L.G., Parikh, A.R., Niedzwiecki, D., Pereira, A.A.L., McKinney, M., Korn, W.M., Atreya, C.E., Banks, K.C., Nagy, R.J., Meric-Bernstam, F., Lanman, R.B., Talasaz, A., Tsigelny, I.F., Corcoran, R.B. and Kopetz, S. (2018) Genomic Landscape of Cell-Free DNA in Patients with Colo-rectal Cancer. Cancer Discovery, 8, 164-173.
https://doi.org/10.1158/2159-8290.CD-17-1009
[24]  Flamini, E., Mercatali, L., Nanni, O., Calistri, D., Nunziatini, R., Zoli, W., Rosetti, P., Gardini, N., Lattuneddu, A., Verdecchia, G.M. and Amadori, D. (2006) Free DNA and Carcinoembryonic Antigen Serum Levels: An Important Combination for Diagnosis of Colorectal Cancer. Clinical Cancer Research, 12, 6985-6988.
https://doi.org/10.1158/1078-0432.CCR-06-1931
[25]  Kinugasa, H., Nouso, K., Ako, S., Dohi, C., Matsushita, H., Matsumoto, K., Kato, H. and Okada, H. (2018) Liquid Biopsy of Bile for the Molecular Diagnosis of Gallbladder Cancer. Can-cer Biology & Therapy, 19, 934-938.
https://doi.org/10.1080/15384047.2018.1456604
[26]  Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. and Bray, F. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249.
https://doi.org/10.3322/caac.21660
[27]  Eissa, M.A.L., Lerner, L., Abdelfatah, E., Shankar, N., Canner, J.K., Hasan, N.M., Yaghoobi, V., Huang, B., Kerner, Z., Takaesu, F., Wolfgang, C., Kwak, R., Ruiz, M., Tam, M., Pisanic, T.R., Iacobuzio-Donahue, C.A., Hruban, R.H., He, J., Wang, T.H., Wood, L.D., Sharma, A. and Ahuja, N. (2019) Promoter Methyl-ation of ADAMTS1 and BNC1 as Potential Biomarkers for Early Detection of Pancreatic Cancer in Blood. Clinical Epigenetics, 11, Article No. 59.
https://doi.org/10.1186/s13148-019-0650-0
[28]  Sikora, K., Bedin, C., Vicentini, C., Malpeli, G., D’Angelo, E., Speran-dio, N., Lawlor, R.T., Bassi, C., Tortora, G., Nitti, D., Agostini, M., Fassan, M. and Scarpa, A. (2015) Evaluation of Cell-Free DNA as a Biomarker for Pancreatic Malignancies. The International Journal of Biological Markers, 30, E136-E141.
https://doi.org/10.5301/jbm.5000088
[29]  Singh, N., Gupta, S., Pandey, R.M., Chauhan, S.S. and Saraya, A. (2015) High Levels of Cell-Free Circulating Nucleic Acids in Pancreatic Cancer Are Associated with Vascular Encasement, Metastasis and Poor Survival. Cancer Investigation, 33, 78-85.
https://doi.org/10.3109/07357907.2014.1001894
[30]  Driescher, C., Fuchs, K., Haeberle, L., Goering, W., Frohn, L., Opitz, F.V., Haeussinger, D., Knoefel, W.T., Keitel, V. and Esposito, I. (2020) Bile-Based Cell-Free DNA Analysis Is a Reliable Diagnostic Tool in Pancreatobiliary Cancer. Cancers (Basel), 13, Article No. 39.
https://doi.org/10.3390/cancers13010039
[31]  Shen, N., Zhang, D., Yin, L., Qiu, Y., Liu, J., Yu, W., Fu, X., Zhu, B., Xu, X., Duan, A., Chen, Z., Wang, X., Cao, X., Zhao, T., Zhou, Z., Yu, L., Qin, H., Fang, Z., Li, J.Y., Liu, Y., Xiong, L., Yu-an, B., Li, F. and Zhang, Y. (2019) Bile Cell-Free DNA as a Novel and Powerful Liquid Biopsy for Detecting Somatic Variants in Biliary Tract Cancer. Oncology Reports, 42, 549-560.
https://doi.org/10.3892/or.2019.7177

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