The effect of enterotoxins is to induce the production of endogenous IF. St. aureus enteropathogenic proteins (enterotoxins) possess an antitumour effect. After intraperitoneal inoculation, they decrease the size and, in some cases, prevent the development of the human hypernephroma in the cheek pouch of golden hamsters. The effect of enteropathgenic proteims may possibly consist in inducing the production of endogenous immune interferon which activates the host immune system and enhances the rejection of heterologous tumour cells.
References
[1]
Bergdoll, M.S. (1966) Immunization of Rhesus Monkeys with Enterotoxoid B. The Journal of Infectious Diseases, 116, 191-196. https://doi.org/10.1093/infdis/116.2.191
[2]
Ortega, E., Abriouel, H., Lucas, R. and Gálvez, A. (2010) Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance. Toxins, 2, 2117-2131. https://doi.org/10.3390/toxins2082117
[3]
Ahanotu, E., Alvelo-Ceron, D., Ravita, T. and Gaunt, E. (2012) Staphylococcal Enterotoxin B as a Biological Weapon: Recognition, Management, and Surveillance of Staphylococcal Enterotoxin. Applied Biosafety, 11, 120-126. https://doi.org/10.1177/153567600601100303
[4]
Ezepchuk, Y.V., Morgan, S.D. and Major, P. (1981) A Simple Procedure for Isolation and Purification of A-Type Staphylococcus Enterotoxin. Acta microbiologica Academiae Scientiarum Hungaricae, 28, 25-30.
[5]
Ezepchuk, Y.V., Noskova, V.P., Aspetov, R.D., et al. (1983) Binding of Staphylococcal Enterotoxin a (Sea) with Human Splenic Lymphocytes. International Journal of Biochemistry, 15, 285-288. https://doi.org/10.1016/0020-711X(83)90092-7
Balkwill, F.R., Modil, E.M., Freedman, V., et al. (1983) An Animal Model System for Investigating the Antitumor Effects of Human Interferon. Journal of Interferon Research, 3, 319-326. https://doi.org/10.1089/jir.1983.3.319
[8]
Gresser, I., Maury, C., Bandy, M.T., et al. (1984) Inhibitory Effect of Mouse Interferon on the Growth of an Embryonal Carcinoma in Mice. Journal of Interferon & Cytokine Research, 4, 375-381. https://doi.org/10.1089/jir.1984.4.375
[9]
Gresser, I. (1983) Possible Mechanisms Responsible for the Antitumor Effect of Interferon (IFN) in Mice. International Symposium of Interferons, p. 22.
Jonson, H.М. and Torres, В.A. (1983) Recombinant Mouse Interferon Regulation of Antibody Production. Infection and Immunity, 41, 546-548. https://doi.org/10.1128/iai.41.2.546-548.1983
[12]
de Maeyer, E. and de Maeyer-Guignard, J. (1982) Immuno-Modulating Properties of Interferons. Philosophical Transactions of the Royal Society B, 299, 77-89.
[13]
Berish, R.J., Sekar, V. and Martimucci, W.A. (1983) Comparative Antiproliferative Efficacies of Human α and γ Interferons. Journal of General Virology, 64, 1743-1748. https://doi.org/10.1099/0022-1317-64-8-1743
[14]
Shevlyagin, V.Y., Shaposhnikova, G.M., Snegireva, A.E., et al. (1985) Characteristics of the Cell Line Obtained from Human Hypernephroma. Nauchnye Doki Vyss Shkoly Biol Nauki, No. 6, 29-33.
[15]
Soloviev, V.D. and Bektemirov, T.A. (1981) Interferons in theory and practice of medicine. Medicine, Moscow, p. 400.
[16]
Mentkevich, L.M., Zhdanova, L.V., Meshkova, E.N. and Ezepchuk, Y.V. (1983) Formation of Immune Interferon Induced by Staphylococcal Enterotoxin and Phytohaemagglutinin. Virology Concerns, No. 1, 58-62.
[17]
Kunevich, N.P., Anatolii, S.A. and Ezepchuk, Y.V. (1982) The Effect of Staphylococcal Enterotoxins A and B on the Proliferative Activity of Lymphocytes and the Primary Immune Response. Immunology, No. 6, 60-62.
[18]
Shcheglovitova, O.N., Ezepchuk, Y.V. and Orlova, T.G. (1989) Effect of Spleen Cells Sensitized with Staphylococcal Enterotoxin Type A on the Metastasis of Lewis Lung Carcinoma in Mice. Experimental Oncology, 11, 54-57.
[19]
Kostyukova, N.N. and Fluer, F.S. (2019) Professor Yurii V. Ezepchur Is One of the Founders of the Molecular Study of the Bacterial Pathgenicity Factors in Our Country. Intern. Konf. Stoch. Reading, Moscow, 219-222. http://www.spsl.nsc.ru/FullText/konfe/%D0%A1%D1%82%D0%BE%D1%87%D0%B8%D0%BA%D0%BE%D0%B22019.pdf
[20]
Ezepchuk, Y.V. (2022) Biological Concept of Bacterial Pathogenicity. Research Advances in Microbiology and Biotechnology, 1, 36-47. https://doi.org/10.9734/bpi/ramb/v1/4072E
