Background: Juvenile idiopathic arthritis (JIA) is the most
common rheumatic disease inchildren.
Both the humoral and cell mediated immunities are involved in the pathogenesis of JIA. It is
reported that overall immunoglobulin levels in JIA patients are significantly
higher than their control during the active state of disease. Methodology: This
prospective observational study was conducted over a period of 18 months All
the newly diagnosed oligo-articular and poly-articular JIA patients having
active disease were included by purposive sampling. Data were collected by a
semi-structured predesigned questionnaire. Result: Most of the study
subjects (57.6%) belonged to age group >3 - 9 years. Oligo JIA was diagnosed in 66.7% and
poly JIA in 33.3%of JIA
children. The difference inmean
(±SD) ESR (33.52±21.29 and 15.09±7.71 mm in 1st hour) at active and inactive stateswas highly significant. Mean
(±SD) difference of IgG, IgM and IgA in active and inactive statesof disease were highly
significant. Conclusion: Higher and abnormal levels of immunoglobulin
(IgG, IgM, and IgA) were present among JIA patientsin active
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