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Medical Diagnosis 2024
PSMD2在肿瘤中的研究进展
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Abstract:
泛素蛋白酶体途径(Alterations in the ubiquitin-proteasome system UPS)，是由泛素介导的一种高度复杂的蛋白降解系统，普遍参与各种生物学功能，例如细胞生长，细胞周期进程，DNA转录、损伤、修复和信号转导及自噬，因此在体内各种调节蛋白的降解和整体细胞的稳态中发挥着至关重要的作用。UPS的表达功能异常或改变可能导致蛋白质的积累，与人类多种疾病相关，包括恶性肿瘤、血液系统疾病等。其中泛素化是泛素蛋白酶体系统途径的关键步骤，PSMD2 (proteasome 26S subunit, non-ATPase 14)位于蛋白酶体26S亚基，是一种非ATP酶组分，是泛素–蛋白酶体的重要组成部分之一。近年来，其在疾病发生发展中的作用越来越受到关注，本文将对PSMD2的结构、作用机制及在不同疾病中的研究进展进行综述。
Alterations in the ubiquitin-proteasome system UPS, a highly complex protein degradation system mediated by ubiquitin, are commonly involved in a variety of biological functions, such as cell growth, cell cycle processes, DNA transcription, damage, repair and signal transduction, as well as autophagy, therefore play a crucial role in the degradation of various regulatory proteins in the body and overall cell homeostasis. Abnormal or altered expression function of UPS may lead to accumulation of proteins, which is associated with a variety of human diseases, including malignant tumors and diseases of the blood system. Ubiquitination is a key step in the pathway of the ubiquitin-proteasome system. PSMD2 (proteasome 26S subunit, non-ATPase 14), which is located in the 26S subunit of the proteasome, is a non-ATPase component and one of the important components of ubiquitin-proteasome. In recent years, the role of PSMD2 in the occurrence and development of diseases has attracted more and more attention. In this article, the structure, mechanism of action and research progress of PSMD2 in different diseases will be reviewed.
| [1] | 段远胜, 井超, 王旭东. 去泛素化酶PSMD14在肿瘤中的研究进展[J]. 中国肿瘤临床, 2022, 49(8): 407-410. |
| [2] | 李兴爽, 王洋, 金一. 泛素-蛋白酶体系统研究进展[J]. 畜牧与兽医, 2016, 48(3): 137-141. |
| [3] | 孙格格, 李新. 去泛素化酶与妇科恶性肿瘤相关研究进展[J]. 医学综述, 2022, 28(2): 265-270. |
| [4] | Komander, D., Clague, M.J. and Urbe, S. (2009) Breaking the Chains: Structureand Function of the Deubiquitinases. Nature Reviews Molecular Cell Biology, 10, 550-563. https://doi.org/10.1038/nrm2731 |
| [5] | 杨瑛, 泛素-蛋白酶体系在上皮性卵巢癌的差异性表达研究及阻断泛素-蛋白酶体途径促凋亡作用机制的初步分析[D]: [博士学位论文]. 成都: 四川大学, 2007. |
| [6] | 俞纪东, 何松青. 泛素-蛋白酶体系统及蛋白酶体抑制剂在实体瘤治疗中作用的研究进展[J]. 中华实验外科杂志, 2017, 34(1): 174-176. |
| [7] | 玛依拉·卡米力江, 哈丽丹·热依木, 阿丽叶古丽·艾皮热木, 等. 宫颈癌发生与血浆RelB和PSMD10蛋白质表达调控的关系及临床意义[J]. 医学研究杂志, 2017, 46(5): 28-31. |
| [8] | Guberman, M., Gang, H., Margulets, V., Jassal, D.S., Alagarsamy, K.N., Dhingra, S., Valenzuela Ripoll, C., Billia, F., Diwan, A., Javaheri, A. and Kirshenbaum, L.A. (2022) Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy. Circulation, 146, 934-954. https://doi.org/10.1161/CIRCULATIONAHA.121.058411 |
| [9] | Harit, K., Bhattacharjee, R., Matuschewski, K., Becker, J., Kalinke, U., SchlüTer, D. and Nishanth, G. (2023) the Deubiquitinating Enzyme OTUD7b Protects Dendritic Cells From TNF-Induced Apoptosis by Stabilizing the E3 Ligase TRAF2. Cell Death & Disease, 14, 480. https://doi.org/10.1038/s41419-023-06014-5 |
| [10] | Dhingra, R., Rabinovich-Nikitin, I., Rothman, S., Guberman, M., Gang, H., Margulets, V., Jassal, D.S., Alagarsamy, K.N., Dhingra, S., Valenzuela Ripoll, C., Billia, F., Diwan, A., Javaheri, A. and Kirshenbaum, L.A. (2022) Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy. Circulation, 146, 934-954. https://doi.org/10.1161/CIRCULATIONAHA.121.058411 |
| [11] | Liu, Y., Wu, M., Xu, S., Niu, X., Liu, W., Miao, C., Lin, A., Xu, Y. and Yu, L. (2023) PSMD2 Contributes To the Progression of Esophageal Squamous Cell Carcinoma by Repressing Autophagy. Cell & Bioscience, 13, 67. https://doi.org/10.1186/s13578-023-01016-4 |
| [12] | Wang, S., Wang, H., Zhu, S. and Wang, Z. (2022) PSMD2 Promotes the Progression of Bladder Cancer and Is Correlated with Immune Infiltration. Frontiers in Oncology, 12, 1058506. https://doi.org/10.3389/fonc.2022.1058506 |
| [13] | Salah Fararjeh, A., Al-Khader, A., Al-Saleem, M. and Abu Qauod, R. (2021) the Prognostic Significance of Proteasome 26S Subunit, Non-Atpase (PSMD) Genes for Bladder Urothelial Carcinoma Patients. Cancer Informatics, 20, 117693. https://doi.org/10.1177/11769351211067692 |
| [14] | Matsuyama, Y., Suzuki, M., Arima, C., Huang, Q.M., Tomida, S., Takeuchi, T., Sugiyama, R., Itoh, Y., Yatabe, Y., Goto, H. and Takahashi, T. (2011) Proteasomal Non-Catalytic Subunit PSMD2 as a Potential Therapeutic Target in Association with Various Clinicopathologic Features in Lung Adenocarcinomas. Molecular Carcinogenesis, 50, 301-309. https://doi.org/10.1002/mc.20632 |
| [15] | Zhao, H. and Lu, G. (2022) Prognostic Implication and Immunological Role of PSMD2 in Lung Adenocarcinoma. Frontiers in Genetics, 13, 905581. https://doi.org/10.3389/fgene.2022.905581 |
| [16] | Li, Y., Huang, J., Zeng, B., Yang, D., Sun, J., Yin, X., Lu, M., Qiu, Z., Peng, W., Xiang, T., Li, H. and Ren, G. (2018) PSMD2 Regulates Breast Cancer Cell Proliferation and Cell Cycle Progression by Modulating P21 and P27 Proteasomal Degradation. Cancer Letters, 430, 109-122. https://doi.org/10.1016/j.canlet.2018.05.018 |
| [17] | Ying, K., Wang, C., Liu, S., Kuang, Y., Tao, Q. and Hu, X. (2022) Diverse Ras-Related Gtpase DIRAS2, Downregulated by PSMD2 in A Proteasome-Mediated Way, Inhibits Colorectal Cancer Proliferation by Blocking NF-ΚB Signaling. International Journal of Biological Sciences, 18, 1039-1050. https://doi.org/10.7150/ijbs.68312 |
| [18] | Gu, C., Wang, Y., Zhang, L., Qiao, L., Sun, S., Shao, M., Tang, X., Ding, P., Tang, C., Cao, Y., Zhou, Y., Guo, M., Wei, R., Li, N., Xiao, Y., Duan, J. and Yang, Y. (2022) AHSA1 Is A Promising Therapeutic Target For Cellular Proliferation and Proteasome Inhibitor Resistance in Multiple Myeloma. Journal of Experimental & Clinical Cancer Research, 41, 11. https://doi.org/10.1186/s13046-021-02220-1 |
| [19] | 崔珍珍. 蛋白酶体亚基PSMD2对HIV-1基因转录延伸调控的机制研究[D]: [硕士学位论文]. 厦门: 厦门大学, 2021. |
| [20] | 熊秋宏, 李文静, 吴长新. 自噬和泛素-蛋白酶体系统之间的交联[J]. 中国生物化学与分子生物学报, 2018, 34(11): 1154-1159. |
| [21] | Xiong, Q., Fischer, S., Karow, M., MüLler, R., Me？ling, S. and Eichinger, L. (2018) ATG16 Mediates the Autophagic Degradation of the 19S Proteasomal Subunits PSMD1 and PSMD2. European Journal of Cell Biology, 97, 523-532. https://doi.org/10.1016/j.ejcb.2018.09.002 |
