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Coumestan类天然产物合成及其生物活性研究进展
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Abstract:
Coumestans是一类以四环内酯为核心骨架的天然产物，主要存在于蝶形花科(Papilionaceae)，豆科(Leguminosae)，菊科(Compositae)等植物中，具有广泛的药理作用和生理活性，如抗肿瘤、抗菌、抗病毒、止血、治疗骨质疏松、雌激素样作用等。近年来，随着化学合成和生物技术的发展，人们对Coumestan类天然产物的骨架构筑及其生物活性进行了深入研究。本文将全面梳理Coumestan类天然产物的结构特征、骨架构筑方法以及其生物活性方面的最新研究进展。
Coumestans are a class of natural compounds characterized by a four-ring lactone as their core structure. They are predominantly found in plants of the Fabaceae (Papilionaceae), Leguminosae, Compositae, and other botanical families, exhibiting diverse pharmacological and physiological activities such as anti-tumor, antimicrobial, antiviral, hemostatic, treatment of osteoporosis, and estrogenic effects. In recent years, with advancements in chemical synthesis and biotechnology, there has been a profound exploration of the scaffold construction and biological activities of coumestan-type natural products. This article aims to comprehensively review the structural features, methods of scaffold construction, and the latest research developments in the biological activities of coumestan-type natural products.
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