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核因子红细胞系2相关因子2 (Nrf2)在病理性妊娠中的作用
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Abstract:
活性氧的产生和抗氧化还原系统之间的稳态平衡在维持正常妊娠中发挥重要作用，氧化还原系统的失衡会导致各种不良妊娠结局。核因子红细胞系2相关因子2 (nuclear factor erythroid 2-related factor 2, Nrf2)是一种抗氧化关键转录因子，活化的Nrf2可与抗氧化反应元件ARE结合激活各种抗氧化基因，增强细胞的先天抗氧化状态，维持机体氧化还原动态平衡，从而减少怀孕期间各种不利因素对母体及胎儿细胞的氧化应激和炎症损伤。本研究对Nrf2在先兆子痫、IUGR、流产、早产、妊娠期GDM和代谢综合征以及预防孕期环境毒素诱导的不良妊娠结局中的作用进行综述，并分析Nrf2在各种不良妊娠结局(APOs)中可能的作用机制。
The homeostatic balance between the production of reactive oxygen species and the antiredox system plays an important role in maintaining a normal pregnancy, and the imbalance of the redox system leads to a variety of adverse pregnancy outcomes. Nuclear factor erythrocyte 2 related factor 2 (Nrf2) is a key antioxidant transcription factor, activated Nrf2 can combine with antioxidant response element ARE activate various antioxidant genes, enhance the innate antioxidant status of cells, maintain the body redox dynamic balance, during pregnancy to reduce various adverse factors on the maternal and fetal cell oxidative stress and inflammation damage. In this study, the role of Nrf2 in pre-eclampsia, IUGR, abortion, preterm birth, GDM and metabolic syndrome during pregnancy, and prevention of environmental toxin-induced adverse pregnancy outcomes during pregnancy were reviewed, and analyzed the possible mechanisms of Nrf2 in various adverse pregnancy outcomes (APOs).
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