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CD48与配体的相互作用及疾病中的研究进展
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Abstract:
信号转导淋巴细胞激活分子(SLAM)受体家族(SLAMF)是CD2超家族的一组受体，它是由许多造血细胞上表达的几个成员组成的。CD48作为信号淋巴细胞激活分子家族的成员，是一种糖基磷脂酰肌醇(GPI)锚定的细胞表面蛋白，参与免疫细胞的黏附和激活等作用。CD48最初是在病毒诱导的B细胞上发现的，经研究发现其结合CD2和其他分子，但它在小鼠和人类系统中的高亲和力配体是CD244 (2B4)，同时还发现CD48也与一些外源性配体相作用。本文主要介绍CD48结构及其与不同配体之间作用，以及讨论了CD48在哮喘、系统性红斑狼疮、炎症性肠病、血液系统及肝恶性肿瘤等疾病中作用的研究。
The signal transduction lymphocyte activating molecule (SLAM) receptor family (SLAMF) is a group of receptors of the CD2 superfamily, which is composed of several members expressed on many hematopoietic cells. As a member of the family of signal lymphocyte activating molecules, CD48 is a cell surface protein anchored by glycosylphosphatidylinositol (GPI), which participates in the adhesion and activation of immune cells. CD48 was originally found in virus-induced B cells. It was found that it binds CD2 and other molecules, but its high affinity ligand in mouse and human system is CD244 (2B4). It is also found that CD48 also interacts with some exogenous ligands. This paper mainly introduces the structure of CD48 and its interaction with different ligands, and discusses the role of CD48 in asthma, systemic lupus erythematosus, inflammatory bowel disease, hematological system and liver malignant tumors.
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