全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Management of Testicular Cancers in Brazzaville

DOI: 10.4236/oju.2024.145034, PP. 324-332

Keywords: Testicular Cancer, Germ Cell Tumor, Cisplatin, Testicular Lymphoma, Testicular Adenocarcinoma

Full-Text   Cite this paper   Add to My Lib

Abstract:

Introduction: Testicular cancer accounts for 5% of urological tumors, predominantly affecting young men. The aim of our study was to report the diagnostic and evolutionary aspects of testicular cancer cases treated in our center. Patients and Methods: A retrospective study conducted over a 15-year period involving 12 patients treated for testicular cancer at the University Hospital of Brazzaville. Results: The median age was 31 years (range 11 to 49 years), with a median consultation delay of 10.6 months (range 3 to 27 months). Scrotal mass was the most common reason for consultation. Cancer was bilateral in two patients. Two patients were admitted with metastatic disease. Histopathological examination favored germ cell tumors in 7 cases, two cases of non-Hodgkin’s malignant lymphoma, and one case of epididymo-testicular adenocarcinoma. Adjuvant chemotherapy resulted in complete remission in patients with germ cell tumors. However, neoadjuvant chemotherapy was not effective in patients admitted with advanced-stage disease. Conclusion: Testicular cancer is a rare condition that is curable in the majority of cases, but its management is often complicated in our setting due to delayed diagnosis caused by taboos surrounding genital organ pathologies.

References

[1]  Zuniga, K.B., et al. (2020) A Comparison of Stage-Specific All-Cause Mortality between Testicular Sex Cordstromal Tumors and Germ Cell Tumors: Results from the National Cancer Database. BMC Urology, 20, Artile No. 40.
https://doi.org/10.1186/s12894-020-00609-2
[2]  Konan, P.G., Dekou, A., Kouame, B., et al. (2005) Tumeurs malignes du testicule en Côte d’Ivoire: Aspect anatomo-pathologique à propos de 54 cas. African Journal of Urology, 11, 191-196.
[3]  Murez, T., et al. (2020) Recommandations françaises du Comité de Cancérologie de l’AFU—Actualisation 2020-2022: Tumeurs germinales du testicule. Progrès en urologie, 30, 280-313.
https://doi.org/10.1016/S1166-7087(20)30754-5
[4]  Baroni, T., Arato, I., Mancuso, F., Calafiore, R. and Luca, G. (2019) On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer. Frontiers in Endocrinology, 10, Article 343.
https://doi.org/10.3389/fendo.2019.00343
[5]  Dieckmann, K.P. and Pichlmeier, U. (2004) Clinical Epidemiology of Testicular Germ Cell Tumors. World Journal of Urology, 22, 2-14.
https://doi.org/10.1007/s00345-004-0398-8
[6]  Hamilton, R.J., Canil, C., Shani Shrem, N., et al. (2022) Canadian Urological Association Consensus Guideline: Management of Testicular Germ Cell Cancer. Canadian Urological Association Journal, 16, 155-173.
https://doi.org/10.5489/cuaj.7945
[7]  Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al. (2015) Cancer Incidence and Mortality Worldwide: Sources, Methods and Major Patterns in GLOBOCAN 2012. International Journal of Cancer, 136, E359-E386.
https://doi.org/10.1002/ijc.29210
[8]  Stephenson, A., Eggener, S.E., Bass, E.B., Chelnick, D.M., Daneshmand, S., Feldman, D., Gilligan, T., Karam, J.A., Leibovich, B., Liauw, S.L., Masterson, T.A., Meeks, J.J., Pierorazio, P.M., Sharma, R. and Sheinfeld, J. (2019) Diagnosis and Treatment of Early Stage Testicular Cancer: American Urological Association Guideline. The Journal of Urology, 202, 272-281.
https://doi.org/10.1097/JU.0000000000000318
[9]  Goumbri, O.M., Lompo Domagni, O.E., Sanou, A.M., Konsegre, V. and Soudre, R.B. (2009) Aspects épidémiologiques et histopathologiques des cancers au Burkina Faso. Journal africain du cancer, 1, 207-211.
https://doi.org/10.1007/s12558-009-0052-x
[10]  Kane, R., Zakou, A.R.H., Diao, B., Ndiaye, A., Thiam, A., Sow, Y., Ze ondo, C., Fall, B. and Diagne, B.A. (2014) Cancer du testicule: Particularités cliniques et limites thérapeutiques en milieu hospitalier urologique au Sénégal. African Journal of Urology, 20, 149-153.
https://doi.org/10.1016/j.afju.2014.04.003
[11]  Huddart, R.A., Norman, A., Moynihan, C., et al. (2005) Fertility, Gonadal and Sexual Function in Survivors of Testicular Cancer. British Journal of Cancer, 93, 200-207.
https://doi.org/10.1038/sj.bjc.6602677
[12]  Pozza, C., Pofi, R., Tenuta, M., et al. (2019) Clinical Presentation, Management and Follow-Up of 83 Patients with LEYDIG CELL TUMORS of the Testis: A Prospective Case-Cohort Study. Human Reproduction, 34, 1389-1403.
https://doi.org/10.1093/humrep/dez083
[13]  Ates, F., Malkoc, E., Zor, M., Demirer, Z., Alp, B.F., Basal, S., Guragac, A. and Yildirim, I. (2016) Testis-Sparing Surgery in Small Testicular Masses Not Suspected to Be Malignant. Clinical Genitourinary Cancer, 14, E49-E53.
https://doi.org/10.1016/j.clgc.2015.07.016
[14]  Lagabrielle, S., Durand, X., Droupy, S., Izard, V., Marcelli, F., Huyghe, E., Ferriere, J.M. and Ferretti, L. (2018) Testicular Tumours Discovered during Infertility Workup Are Predominantly Benign and Could Initially Be Managed by Sparing Surgery. Journal of Surgical Oncology, 118, 630-635.
https://doi.org/10.1002/jso.25203
[15]  Sow, M., Nkegoum, B., Essame Oyono, J.L., Garoua, M. and Nzokou, A. (2006) Aspects épidémiologiques et histopathologiques des tumeurs urogénitales au Cameroun. Progrès en Urologie, 16, 36-39.
[16]  Kollmannsberger, C., Tandstad, T., Bedard, P.L., Cohn-Cedermark, G., Chung, P.W., Jewett, M.A., et al. (2015) Patterns of Relapse in Patients with Clinical Stage I Testicular Cancer Managed with Active Surveillance. Journal of Clinical Oncology, 33, 51-57.
https://doi.org/10.1200/JCO.2014.56.2116
[17]  Van de Geijn, G.J., Hersmus, R. and Looijenga, L.H. (2009) Recent Developments in Testicular Germ Cell Tumor Research. Birth Defects Research Part C: Embryo Today: Reviews, 87, 96-113.
https://doi.org/10.1002/bdrc.20140
[18]  Fossa, A. and Fossa, S.D. (1989) Serum Lactate Deshydrogenase and Human Choriogonadotrophin in Seminoma. British Journal of Urology, 63, 408-415.
https://doi.org/10.1111/j.1464-410X.1989.tb05228.x
[19]  Klein, E.A. (1993) Tumor Markers in Testis Cancer. Urologic Clinics of North America, 20, 67-73.
https://doi.org/10.1016/S0094-0143(21)00462-6
[20]  Barlow, L.J., Badalato, G.M. and McKiernan, J.M. (2010) Serum Tumor Markers in the Evaluation of Male Germ Cell Tumors. Nature Reviews Urology, 7, 610-617.
https://doi.org/10.1038/nrurol.2010.166
[21]  Giannatempo, P., Greco, T., Mariani, L., et al. (2015) Radiotherapy or Chemotherapy for Clinical Stage IIA and IIB Seminoma: A Systematic Review and Meta-Analysis of Patient Outcomes. Annals of Oncolog, 26, 657-668.
https://doi.org/10.1093/annonc/mdu447
[22]  Miladi, M., Peyromaure, M., Remi, J., Beuzeboc, P., Debre, B. and Zerbib, M. (2003) Tumeurs germinales du testicule: Etude pronostique. Progrès en Urologie, 13, 92-97.
[23]  Sharp, D.S., Carver, B.S., Eggener, S.E., et al. (2008) Clinical Outcome and Predictors of Survival in Late Relapse of Germ Cell Tumor. Journal of Clinical Oncology, 26, 5524-5529.
https://doi.org/10.1200/JCO.2007.15.7453

Full-Text

comments powered by Disqus

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133

WeChat 1538708413