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Pharmacy Information 2024
黑素干细胞及其在白癜风复色过程中的作用研究进展
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Abstract:
黑素干细胞具有无限自我更新能力，在一定条件(如伤口愈合、基因毒性药物处理和紫外线照射等)的刺激下，细胞或组织会通过再生来修复受损，即招募干细胞来分化为成熟的黑素细胞。近年来有研究发现黑素干细胞可作为皮肤和毛发的黑素细胞库，这为许多色素紊乱性疾病的治疗带来了新的希望。本文主要对黑素干细胞进行了介绍，并对黑素干细胞再生的关键信号通路、与邻近细胞之间的串扰及其在白癜风复色过程中的作用进行讨论。
Melanocyte stem cells have an unlimited self-renewal capacity, and under the stimulation of certain conditions (e.g. wound healing, genotoxic drug treatment, and ultraviolet irradiation, etc.), the cells or tissues will repair the damage by regeneration, i.e., recruiting stem cells to differentiate into mature melanocytes. In recent years, it has been found that melanocyte stem cells can serve as a reservoir of melanocytes for the skin and hair, which brings new hope for the treatment of many pigmentation disorders. This paper focuses on melanocyte stem cells and discusses the key signaling pathways of regeneration, crosstalk with neighboring cells and their role in vitiligo repigmentation.
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