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Bioprocess 2024
m6A修饰在砷诱导毒效应中发挥的作用研究进展
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Abstract:
在环境领域中，砷是一种有毒的重金属，主要通过饮用水途径对人类健康造成各种影响。如今，全球约2亿人正受到含砷的饮用水影响，是一个亟待解决的全球性公共卫生问题。N6-甲基腺苷(m6A)修饰是哺乳动物mRNA中最丰富的化学修饰，在越来越多的研究中发现m6A修饰参与了砷诱导毒效应，因此研究异常RNA修饰在重金属毒性中的作用和机制是一个非常有前景的领域。本研究通过参考国内外文献，综述了m6A修饰在砷诱导毒效应中发挥的作用，并为今后探索其它重金属的毒效应机制提供研究方向。
In the environmental field, arsenic is a toxic heavy metal that causes various effects on human health mainly through the drinking water route. Today, about 200 million people are exposed to arsenic from drinking water, which is a global public health problem that needs to be addressed urgently. N6-methyladenosine (m6A) modification is the most abundant chemical modification in mammalian mRNA. More and more studies have found that m6A modification is involved in arsenic-induced toxicity, so studying the role and mechanism of abnormal RNA modification in heavy metal toxicity is a very promising field. This paper reviews the role of m6A modification in arsenic-induced toxicity by referring to domestic and foreign literature, and provides research directions for exploring the toxic mechanism of other heavy metals in the future.
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