The bioactive glass and related biomaterials have become increasingly popular, and have also attracted the research interest of many researchers in recent years due its special performance and tissue engineering application. In this study, to create a material with a variety of properties Mg doped hollow bioactive glass (Mg-HBG) of 80SiO2-5P2O5-10CaO-5MgO system had been produced by using a sol-gel method. The porous structure nanoparticles were specifically made by employing the cetyltrimethylammonium bromide (CTAB) as a surfactant. Magnesium was selected as a doped material with HBG, because it is the most existing cations in the human body which helps for bone metabolism as well as it has antibacterial property. Based on different investigations resulted nanoparticle with the inclusion of the lower molar fractions magnesium has good tested result. For a drug model vancomycin hydrochloride (VAN) was used in this study and it has also good antibacterial activity effect. These findings help the possibility of using Mg-HBG nanoparticles to treat infectious bone abnormalities by demonstrating their compatibility with antibiotics, drug loading and release behavior.
References
[1]
Muschler, G.F., Nakamoto, C. and Griffith, L.G. (2004) Engineering Principles of Clinical Cell-Based Tissue Engineering. The Journal of Bone and Joint Surgery, 86, 1541-1558. https://doi.org/10.2106/00004623-200407000-00029
[2]
Gerhardt, L. and Boccaccini, A.R. (2010) Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering. Materials, 3, 3867-3910. https://doi.org/10.3390/ma3073867
[3]
Arepalli, S.K., Tripathi, H., Hira, S.K., Manna, P.P., Pyare, R. and Singh, S.P. (2016) Enhanced Bioactivity, Biocompatibility and Mechanical Behavior of Strontium Substituted Bioactive Glasses. Materials Science and Engineering: C, 69, 108-116. https://doi.org/10.1016/j.msec.2016.06.070
[4]
Bao, P., Kodra, A., Tomic-Canic, M., Golinko, M.S., Ehrlich, H.P. and Brem, H. (2009) The Role of Vascular Endothelial Growth Factor in Wound Healing. Journal of Surgical Research, 153, 347-358. https://doi.org/10.1016/j.jss.2008.04.023
[5]
Fernandes, H.R., Gaddam, A., Rebelo, A., Brazete, D., Stan, G.E. and Ferreira, J.M.F. (2018) Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering. Materials, 11, Article 2530. https://doi.org/10.3390/ma11122530
[6]
Diba, M., Tapia, F., Boccaccini, A.R. and Strobel, L.A. (2012) Magnesium-Containing Bioactive Glasses for Biomedical Applications. International Journal of Applied Glass Science, 3, 221-253. https://doi.org/10.1111/j.2041-1294.2012.00095.x
[7]
Shoaib, M., Bahadur, A., Iqbal, S., AL-Anazy, M.M., Laref, A., Tahir, M.A., Channar, P.A., Noreen, S., Yasir, M., Iqbal, A. and Ali, K.W. (2021) Magnesium Doped Mesoporous Bioactive Glass Nanoparticles: A Promising Material for Apatite Formation and Mitomycin C Delivery to the MG-63 Cancer Cells. Journal of Alloys and Compounds, 866, Article ID: 159013. https://doi.org/10.1016/j.jallcom.2021.159013
[8]
Hidayat, L.K., Hsu, D.I., Quist, R., Shriner, K.A. and Wong-Beringer, A. (2006) High-Dose Vancomycin Therapy for Methicillin-Resistant Staphylococcus Aureus Infections. Archives of Internal Medicine, 166, 2138-2144. https://doi.org/10.1001/archinte.166.19.2138.
[9]
Rai, A., Senapati, S., Saraf, S.K. and Maiti, P. (2016) Biodegradable Poly(ε-Caprolactone) as a Controlled Drug Delivery Vehicle of Vancomycin for the Treatment of MRSA Infection. Journal of Materials Chemistry B, 4, 5151-5160. https://doi.org/10.1039/c6tb01623e
[10]
Martínez-Vázquez, F.J., Cabanas, M.V., Paris, J.L., Lozano, D. and Vallet-Regí, M. (2015) Fabrication of Novel Si-Doped Hydroxyapatite/Gelatine Scaffolds by Rapid Prototyping for Drug Delivery and Bone Regeneration. Acta Biomaterialia, 15, 200-209. https://doi.org/10.1016/j.actbio.2014.12.021
[11]
Chandrasekaran, A.R., Jia, C.Y., et al. (2011) In Vitro Studies and Evaluation of Metformin Marketed Tablets-Malaysia. Journal of Applied Pharmaceutical Science, 1, 214-217.
[12]
Zhang, K., Wang, H., et al. (2010) Fabrication of Silk Fibroin Blended P (LLA-CL) Nanofibrous Scaffolds for Tissue Engineering. Journal of Biomedical Materials Research Part A, 93, 984-993. https://doi.org/10.1002/jbm.a.32504
[13]
Anna, L., Lao, J. and Josephine, L. (2013) Bioactive Glass Nanoparticles Obtained through Sol-Gel Chemistry. Chemical Communications, 49, 6620-6622. https://doi.org/10.1039/c3cc00003f
[14]
Hench, L.L. and Ethridge, E.C. (1982) Biomaterials: An Interfacial Approach. Academic Press, London.
[15]
Mozafari, M., Banijamali, S., Baino, F., Kargozar, S. and Hill, R.G. (2019) Calcium Carbonate: Adored and Ignored in Bioactivity Assessment. Acta Biomaterialia, 91, 35-47. https://doi.org/10.1016/j.actbio.2019.04.039
[16]
Fiume, E., Migneco, C., Verné, E. and Baino, F. (2020) Comparison between Bioactive Sol-Gel and Melt-Derived Glasses/Glass-Ceramics Based on the Multicomponent SiO2-P2O5-CaO-MgO-Na2O-K2O System. Materials, 13, Article 540. https://doi.org/10.3390/ma13030540
[17]
Souza, M., Crovace, M., et al. (2013) Effect of Magnesium Ion Incorporation on the Thermal Stability, Dissolution Behavior and Bioactivity in Bioglass-Derived Glasses. Journal of Non-Crystalline Solids, 382, 57-65. https://doi.org/10.1016/j.jnoncrysol.2013.10.001
[18]
He, Y., Ingudam, S., Reed, S., Gehring, A., Strobaugh, T.P. and Irwin, P. (2016) Study on the Mechanism of Antibacterial Action of Magnesium Oxide Nanoparticles against Foodborne Pathogens. Journal of Nanobiotechnology, 14, Article No. 54. https://doi.org/10.1186/s12951-016-0202-0
[19]
García-Alvarez, R., Izquierdo-Barba, I. and Vallet-Regí, M. (2017) 3D Scaffold with Effective Multidrug Sequential Release against Bacteria Biofilm. Acta biomaterialia, 49, 113-126. https://doi.org/10.1016/j.actbio.2016.11.028
[20]
Xia, W., Chang, J., Lin, J.P. and Zhu, J.Q. (2008) The pH-Controlled Dual-Drug Release from Mesoporous Bioactive Glass/Polypeptide Graft Copolymer Nanomicelle Composites. European Journal of Pharmaceutics and Biopharmaceutics, 69, 546-552. https://doi.org/10.1016/j.ejpb.2007.11.018
[21]
Higuchi, T. (1963) Mechanism of Sustained-Action Medication. Theoretical Analysis of Rate of Release of Solid Drugs Dispersed in Solid Matrices. Journal of Pharmaceutical Sciences, 52, 1145-1149. https://doi.org/10.1002/jps.2600521210
[22]
Anand, A., Das, P., Nandi, S.K. and Kundu, B. (2020) Development of Antibiotic Loaded Mesoporous Bioactive Glass and Its Drug Release Kinetics. Ceramics International, 46, 5477-5483. https://doi.org/10.1016/j.ceramint.2019.10.264
[23]
Kaur, G., Pandey, O.P., Singh, K., Chudasama, B. and Kumar, V. (2016) Combined and Individual Doxorubicin/Vancomycin Drug Loading, Release Kinetics and Apatite Formation for the CaOCuO-P2O5SiO2-B2O3 Mesoporous Glasses. RSC Advances, 6, 51046-51056. https://doi.org/10.1039/C6RA06829D
[24]
Nawaz, Q., Fuentes-Chandia, M., Tharmalingam, V., Rehman, M.A., et al. (2020) Silibinin Releasing Mesoporous Bioactive Glass Nanoparticles with Potential for Breast Cancer Therapy. Ceramics International, 46, 29111-29119. https://doi.org/10.1016/j.ceramint.2020.08.083
[25]
Mohamed, H.B., El-Shanawany, S.M., Hamad, M.A. and Elsabahy, M. (2017) Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities. Scientific Reports, 7, Article No. 6340. https://doi.org/10.1038/s41598-017-06955-w
