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铁棒锤中的二萜生物碱
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Abstract:
目的：研究铁棒锤Aconitum pendulum Busch的化学成分。方法：铁棒锤提取物采用大孔树脂，硅胶柱层析以及半制备高效液相色谱对其进行分离纯化，根据其波谱数据进行结构解析。结果：从其中分离得到10个化合物，分别鉴定为Songorine (1)、15-acetylsongorine (2)、12-epi-lucidusculine (3)、14-O-acetylneoline (4)、benzoylaconitine (5)、aconitine (6)、3-deoxyaconitine (7)、mesaconitine (8)、10-aconifine (9)、flavaconitine (10)。
Objective: This study aims to analyze the chemical composition of Aconitum pendulum Busch. Methods: The extracts obtained from Aconitum pendulum Busch were purified using macroporous resin, silica gel column chromatography, and semi-preparative high-performance liquid chromatography. The structural analyses were conducted based on their spectral data. Results: Ten compounds were isolated from them and identified as Songorine (1), 15-acetylsongorine (2), 12-epi-lucidusculine (3), 14-O-acetylneoline (4), benzoylaconitine (5), aconitine (6), 3-deoxyaconitine (7), mesaconitine (8), 10-aconifine (9), flavaconitine (10).
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