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β,γ-不饱和-α-酮酸酯在有机合成中的应用研究进展
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Abstract:
β,γ-不饱和-α-酮酸酯是一类具有特殊共轭结构的有机中间体，其在有机合成中可以充当C1、C2、C3和C4合成子，可以用于合成具有手性结构或者非手性结构的化合物，因此，β,γ-不饱和-α-酮酸酯已成为现代有机合成中极具吸引力且用途广泛的合成子。本文重点介绍了β,γ-不饱和-α-酮酸酯作为不同合成子在有机合成中的应用，如不对称1,4-加成反应、[2 + 3]环加成反应、[3 + 2]环加成反应以及构建螺环化合物和六元杂环化合物的应用。
β,γ-Unsaturated-α-ketoesters are a class of organic intermediates with a unique conjugated structure, which can serve as C1, C2, C3, and C4 synthons in organic synthesis, and can be used to synthesize compounds with chiral or non-chiral structures. Therefore, β,γ-unsaturated-α-ketoesters have become highly attractive and versatile building blocks in modern organic chemistry. This review focuses on introducing β,γ-Unsaturation-α- the application of ketone esters as different synthons in organic synthesis, such as asymmetric 1,4-addition reactions, [2 + 3] cycloaddition reactions, [3 + 2] cycloaddition reactions, as well as the construction of spirocyclic compounds and hexagonal heterocyclic compounds.
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