Schisandraechinensis Fructus (SF) is a commonly used herb in Traditional Chinese Medicine (TCM). According to TCM theory, SF can invigorate Qi in the liver and other visceral organs through the meridian system. Furthermore, the liver’s pivotal role in regulating the functions of various visceral organs helps explain how SF can promote holistic health benefits. The main active ingredient of SF, schisandrin B (Sch B), has been found to improve mitochondrial ATP production and enhance glutathione redox status in multiple organs. This could account for the overall protective effects of Sch B on organs. Due to its stronger impact on liver function, the positive influence of Sch B on different organs may be facilitated by signal molecules originating from the liver.
References
[1]
Efferth, T., Shan, L. and Zhang, Z. (2016) Tonic Herbs and Herbal Mixtures in Chinese Medicine. World Journal of Traditional Chinese Medicine, 10, 137-148. https://doi.org/10.15806/j.issn.2311-8571.2015.0037
[2]
Marshall, A.C. (2020) Traditional Chinese Medicine and Clinical Pharmacology. In: Hock, F.J. and Gralinski, M.R., Eds., DrugDiscoveryandEvaluation: MethodsinClinicalPharmacology, Springer International Publishing, 455-482. https://doi.org/10.1007/978-3-319-68864-0_60
[3]
Bansal, S., Pratiksha, K., Gaur, R., Gupta, S., Jadaun, V.P. and Kumari, V. (2024) Comprehensive Review on Schisandra chinensis. PharmacologicalResearch—ModernChineseMedicine, 10, Article ID: 100406. https://doi.org/10.1016/j.prmcm.2024.100406
[4]
Ko, K. and Chiu, P. (2006) Biochemical Basis of the “Qi-Invigorating” Action of Schisandra Berry (Wu-Wei-Zi) in Chinese Medicine. The American Journal of Chinese Medicine, 34, 171-176. https://doi.org/10.1142/s0192415x06003734
[5]
Zhang, Y. and Fang, X. (2023) The Pan-Liver Network Theory: From Traditional Chinese Medicine to Western Medicine. Chinese Journal of Physiology, 66, 401-436. https://doi.org/10.4103/cjop.cjop-d-22-00131
[6]
Xutian, S. (2014) The Manifestation of the Internal Organs (ZangXiang, 藏象). In: Xutian, S., Tai, S., Yuan, C., Wozniak, J. and Zhang, J., Eds., HandbookofTraditionalChineseMedicine, World Scientific, 43-72. https://doi.org/10.1142/9789814293839_0004
[7]
Chiu, P.Y. and Ko, K.M. (2006) Schisandrin B‐Induced Increase in Cellular Glutathione Level and Protection against Oxidant Injury Are Mediated by the Enhancement of Glutathione Synthesis and Regeneration in AML12 and H9c2 Cells. BioFactors, 26, 221-230. https://doi.org/10.1002/biof.5520260401
[8]
Chiu, P.Y., Leung, H.Y., Poon, M.K.T., Mak, D.H.F. and Ko, K.M. (2006) Effects of Schisandrin B Enantiomers on Cellular Glutathione and Menadione Toxicity in AML12 Hepatocytes. Pharmacology, 77, 63-70. https://doi.org/10.1159/000092773
[9]
Leong, P.K., Chen, N. and Ko, K.M. (2013) Schisandrin B Enhances Hepatic/Myocardial Glutathione Regeneration Capacity and Protects against Oxidant Injury in Rat Livers and Hearts. The Open Nutraceuticals Journal, 6, 124-128. https://doi.org/10.2174/1876396001306010124
[10]
Nasser, M.I., Zhu, S., Chen, C., Zhao, M., Huang, H. and Zhu, P. (2020) A Comprehensive Review on Schisandrin B and Its Biological Properties. Oxidative Medicine and Cellular Longevity, 2020, Article ID: 2172740. https://doi.org/10.1155/2020/2172740
[11]
Leung, H.Y., Sze, S.C. and Ko, K.M. (2024) Pharmacological Investigation on the Qi-Invigorating Action of Schisandrin B: Effects on Mitochondrial ATP Generation in Multiple Tissues and Innate/Adaptive Immunity in Mice. ChineseMedicine, 15, 15-26. https://doi.org/10.4236/cm.2024.152002
[12]
Ko, K.M., Chen, N., Leung, H.Y., Leong, E.P.K., Poon, M.K.T. and Chiu, P.Y. (2008) Long‐Term Schisandrin B Treatment Mitigates Age‐Related Impairments in Mitochondrial Antioxidant Status and Functional Ability in Various Tissues, and Improves the Survival of Aging C57BL/6J Mice. BioFactors, 34, 331-342. https://doi.org/10.1002/biof.5520340408
[13]
Lam, P.Y., Chiu, P.Y., Leung, H.Y., Chen, N., Leong, P.K. and Ko, K.M. (2010) Schisandrin B Co-Treatment Ameliorates the Impairment on Mitochondrial Antioxidant Status in Various Tissues of Long-Term Ethanol Treated Rats. Fitoterapia, 81, 1239-1245. https://doi.org/10.1016/j.fitote.2010.08.010
[14]
Chiu, P.Y., Lam, P.Y., Yan, C.W. and Ko, K.M. (2011) Schisandrin B Protects against Solar Irradiation-Induced Oxidative Injury in BJ Human Fibroblasts. Fitoterapia, 82, 682-691. https://doi.org/10.1016/j.fitote.2011.02.010
[15]
Lam, P.Y., Leong, P.K., Chen, N. and Ko, K.M. (2011) Schisandrin B Enhances the Glutathione Redox Cycling and Protects against Oxidant Injury in Different Types of Cultured Cells. BioFactors, 37, 439-446. https://doi.org/10.1002/biof.179
[16]
Lam, P.Y. and Ming Ko, K. (2011) (−)schisandrin B Ameliorates Paraquat‐Induced Oxidative Stress by Suppressing Glutathione Depletion and Enhancing Glutathione Recovery in Differentiated PC12 Cells. BioFactors, 37, 51-57. https://doi.org/10.1002/biof.136
[17]
Chiu, P.Y., Luk, K.F., Leung, H.Y., Ng, K.M. and Ko, K.M. (2008) Schisandrin B Stereoisomers Protect against Hypoxia/Reoxygenation-Induced Apoptosis and Inhibit Associated Changes in Ca2+-Induced Mitochondrial Permeability Transition and Mitochondrial Membrane Potential in H9c2 Cardiomyocytes. LifeSciences, 82, 1092-1101. https://doi.org/10.1016/j.lfs.2008.03.006
[18]
Chen, N., Chiu, P.Y. and Ko, K.M. (2008) Schisandrin B Enhances Cerebral Mitochondrial Antioxidant Status and Structural Integrity, and Protects against Cerebral Ischemia/Reperfusion Injury in Rats. BiologicalandPharmaceuticalBulletin, 31, 1387-1391. https://doi.org/10.1248/bpb.31.1387
[19]
Chiu, P.Y., Luk, K.F., Leung, H.Y., Ng, K.M. and Ko, K.M. (2009) Schisandrin B Stereoisomers Protect against Hypoxia/Reoxygenation‐Induced Apoptosis and Associated Changes in the Ca2+‐Induced Mitochondrial Permeability Transition and Mitochondrial Membrane Potential in AML12 Hepatocytes. PhytotherapyResearch, 23, 1592-1602. https://doi.org/10.1002/ptr.2826
[20]
Chiu, P.Y., Chen, N., Leong, P.K., Leung, H.Y. and Ko, K.M. (2010) Schisandrin B Elicits a Glutathione Antioxidant Response and Protects against Apoptosis via the Redox-Sensitive ERK/Nrf2 Pathway in H9c2 Cells. MolecularandCellularBiochemistry, 350, 237-250. https://doi.org/10.1007/s11010-010-0703-3
[21]
Leong, P.K., Chiu, P.Y., Chen, N., Leung, H. and Ko, K.M. (2011) Schisandrin B Elicits a Glutathione Antioxidant Response and Protects against Apoptosis via the Redox-Sensitive Erk/Nrf2 Pathway in AML12 Hepatocytes. FreeRadicalResearch, 45, 483-495. https://doi.org/10.3109/10715762.2010.550917
[22]
Matsumaru, D. and Motohashi, H. (2021) The KEAP1-NRF2 System in Healthy Aging and Longevity. Antioxidants, 10, Article No. 1929. https://doi.org/10.3390/antiox10121929
[23]
Marí, M., de Gregorio, E., de Dios, C., Roca-Agujetas, V., Cucarull, B., Tutusaus, A., et al. (2020) Mitochondrial Glutathione: Recent Insights and Role in Disease. Antioxidants, 9, Article No. 909. https://doi.org/10.3390/antiox9100909
[24]
Picard, M. and Shirihai, O.S. (2022) Mitochondrial Signal Transduction. CellMetabolism, 34, 1620-1653. https://doi.org/10.1016/j.cmet.2022.10.008
[25]
Marí, M., Morales, A., Colell, A., García-Ruiz, C. and Fernández-Checa, J.C. (2009) Mitochondrial Glutathione, a Key Survival Antioxidant. Antioxidants&RedoxSignaling, 11, 2685-2700. https://doi.org/10.1089/ars.2009.2695
[26]
Ayer, A., Fazakerley, D.J., James, D.E. and Stocker, R. (2022) The Role of Mitochondrial Reactive Oxygen Species in Insulin Resistance. FreeRadicalBiologyandMedicine, 179, 339-362. https://doi.org/10.1016/j.freeradbiomed.2021.11.007
[27]
Bonomini, F., Rodella, L.F. and Rezzani, R. (2015) Metabolic Syndrome, Aging and Involvement of Oxidative Stress. AgingandDisease, 6, 109-120. https://doi.org/10.14336/ad.2014.0305
[28]
Spahis, S., Borys, J. and Levy, E. (2017) Metabolic Syndrome as a Multifaceted Risk Factor for Oxidative Stress. Antioxidants&RedoxSignaling, 26, 445-461. https://doi.org/10.1089/ars.2016.6756
[29]
Tain, Y. and Hsu, C. (2022) Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of Oxidative Stress. Antioxidants, 11, Article No. 2108. https://doi.org/10.3390/antiox11112108
[30]
Ko, K.M., Mak, D.H.F., Li, P.C., Poon, M.K.T. and Ip, S.P. (1996) Protective Effect of a Lignan-Enriched Extract of Fructus schisandrae on Physical Exercise Induced Muscle Damage in Rats. PhytotherapyResearch, 10, 450-452. https://doi.org/10.1002/(sici)1099-1573(199608)10:5<450::aid-ptr872>3.0.co;2-p
