Trombocitopenia severa neonatal

introduction: thrombocytopenia in the first hours of life is generally due to maternal factors or perinatal events. alloimune thrombocytopenia, although underdiagnosed, is the most frequent type of severe thrombocytopenia in a term and otherwise healthy newborn, resulting from an immune mediated destruction of foetal/neonatal platelets by maternal alloantibodies. case report: we present the case of a newborn with alloimune thrombocytopenia, a typical clinical presentation and good outcome, highlighting the positive impact in the prognosis of a high index of suspicion and of empirical treatment with hpa-1a negative platelets. conclusion: an early diagnosis of this entity allows effective treatment with the infusion of compatible platelets, preventing eventual complications, namely intracranial haemorrhage. also guides the monitoring of future pregnancies and antenatal treatment.