ACTIVIDAD ANTIINFLAMATORIA DE EXTRACTOS Y FRACCIONES DE Myrcianthes leucoxila, Calea prunifolia, Curatella americana Y Physalis peruviana EN LOS MODELOS EDEMA AURICULAR POR TPA, EDEMA PLANTAR POR CARRAGENINA Y ARTRITIS INDUCIDA POR COLáGENO

introduction. ethnopharmacological use of plants in management of chronic inflammatory diseases and the need to have their pharmacological characterization promote the evaluation of anti-inflammatory activity over in vivo models. materials and methods. evaluation of extracts and fractions of calea prunifolia (cp), curatella americana (ca), myrcianthes leucoxila(ml) and physalis peruviana (pp) on auricular edema by tetradecanoylphorbol acetate (tpa)-in icr albino mice and carrageenan-induced leg edema in wistar rats selecting an extract to evaluate its anti-arthritic activity in collagen-induced arthritis model in dba mice. results. the fractions with greater edema inhibition percentage on tpa-induced ear edema included whole ethanolic fraction of ml (82±6%), cp terpenes rich fraction (81±6%) and ca terpenes rich fraction (81±7%) (p<0.05). significant antiinflamatory activity was not obtained on the carrageenan-induced leg edema. evaluation of antiarthritic activityof the ml terpenes rich fraction was carried out on collagen induced arthritis. without finding any significant effect on back leg edema, corporal weight, arthritis histopathology severity scale or immunohistochemical tumoral necrosis factor alfa immunohistochemical evaluation (p>0.05). discussion. anti-inflammatory activity in tpainduced acute ear edema model for cp, ca, and ml extracts and fractions can be interfered by phospholipase a2 related mediators due to similar effect with indomethacin was found. the ml terpens rich fraction neither show any anti-arthritic activity nor affected tnf-a expression on the autoimmune chronic arthritis model used, reason why it does not have immunomodulatory/anti-inflammatory effect on the evaluated dose. conclusion. ca and cp terpenic rich fractions and ml ethanol extract showed significant anti-inflammatory activity in tpa-induced ear edema. they did have some activity in carrageenan-induced leg edema. the ml terpenic rich fraction did not have anti-arthritic activit