Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

purpose: to evaluate the effect of aqueous extract of hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. methods: sixteen rats were divided in two groups: c (control group) and hf (whose rats received aqueous extract of hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). on the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the pcna immunohistochemical technique. results: the liver regeneration index of hf group was 53.56 ± 18.91%, while in c group was 21.12 ± 8.29% (p=0.0003). conclusion: these results show that the administration of aqueous extract of hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group hf.