Suplementa？？o de vitamina C n？o acelera o processo de consolida？？o de fratura da tíbia em ratos

objective: to investigate the role of ascorbic acid supplementation on bone healing after rat tibia fracture. methods: thirty male wistar rats were randomly divided into vitamin c (group a) and sham (group b) groups (15 rats each). group a received 200 mg intraperitoneally per kg per day of ascorbic acid and group b was given saline 5 ml per kg per day intraperitoneally once a day. the animals were caged in pairs and allowed free access to tap water and a standard rodent chow ad libitum. fractures were produced manually, they were not stabilized, and unprotected weight-bearing was allowed. at two, four, and six weeks post-fracture, the rats in both groups were anesthetized and sacrificed by cervical dislocation. callus tissue was dissected, prepared, and analyzed histologically. histomorphological analysis was performed at six weeks post-fracture and the extent of fracture healing was determined using a five-point scale. results: there were no histological and histomorphological differences between drug-treated animals and the shamin the three different stages studied. by six weeks post-fracture, the five animals of each group had a complete bone union. conclusion: under the studied conditions, intraperitoneal vitamin c supplementation does not accelerate the fracture healing process after experimental tibia fracture in rats. level of evidence: level 2, individual study with experimental design.