Resultados de implante de semillas de iodo-125 con sistema de preplanificación en 250 pacientes con carcinoma de próstata

introduction: we review the experience with prostate carcinoma patients treated with permanent implants of 125-i seeds and the outcome eight years after the beginning of this technique. material and methods: from 2002 to 2007 we have performed 250 implants with ldr brachytherapy with rapidstrand？ and preplanning system. mean age was 68 (49-78). mean psa was 7.32 (2.31 - 14.6). t1-t2a was the stage in 98%, and gleason < 6 in 96%. low risk cases were 81% and intermediate risk 19% (ten of them received 46gy ebrt). hormonal treatment was used in 42%. results: with a mean follow-up of 48 months, 14 patients (5.7%) showed biochemical failure (bf). eleven patients (4.5%) with theoretical bf were observed and psa decreased without treatment. actuarial psa relapse-free survival at 5 years was 91%, (92% low risk, 86% intermediate cases), and 92% vs 81% with psa <10 vs >10 (p<0.05). rectum complications were g2 in 0.6%. a urinary catheter was necessary in 6.5%. sexual function was conserved in 60%. mean v100 was 89% and d90 143gy. conclusion: the outcome of patients with low risk prostate carcinoma treated with i-125 seed is very good with very low complications rate. cases with psa bounces should be controlled before starting a salvage treatment.